Organic polarography

Pietrzyk, Donald J.

doi:10.1021/ac60287a023

Cited by 8 publications

(5 citation statements)

References 179 publications

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“…However, at slow sweeps an inverse peak occurs on the reverse sweep, indicating a radical intermediate presumably reacting with the mercury drop (10). In this case, the addition of mercury to the surface (reaction [3] ) may be responsible for the unusual behavior. The first and second reductions were indistinguishable in the cyclic voltammograms in 50% ethanol (Fig.…”

Section: Discussionmentioning

confidence: 94%

“…Apparently, two reaction pathways are required to explain the two products observed in macroelectrolyses. Reaction [3] is shown as simple…”

Section: Discussionmentioning

confidence: 99%

“…This second peak was found to correspond to that for the reduction of III in 50% ethanol. The III is formed at the first reduction by reactions [3], [10], or [11] (see below) and remains at the drop surface long enough to be reduced when its reduction potential is reached. During polarographic reduction a two-electron reduction not leading to III (see below) is already occurring when the potential of the reduction of III is reached and, therefore, no wave is obtained.…”

Section: Discussionmentioning

confidence: 99%

“…) Hg + R2NCH2CH2" slow le R2N(--) + CH2=CH2 [6] at this potential, but the beta-amino group may allow the reduction to occur rapidly. At higher concentrations (coulometry and macroelectrolysis) reaction [3] predominates. In 50% ethanol the rate of reaction [5] may be faster than that of reaction [6].…”

Section: IVmentioning

confidence: 99%

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The Electroreduction of Beta-Aminoethyl Mercurials

Wagenknecht¹

1972

J. Electrochem. Soc.

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2‐(Piperidino)‐ethylmercuric chloride (I) and 2‐(diethylamino) ethylmercuric chloride (II) are each reduced by two separate one‐electron reductions in DMF or 50% ethanol. The products formed are the corresponding bis‐2‐ aminoethylmercury compound and/or the secondary amine (piperidine or diethylamine) depending on the solvent and reduction potential. Only traces of tertiary amine were detected. Bis[2‐(piperidino)‐ethyl] mercury (II) is reduced to piperidine in 50% ethanol, but no reduction occurs in DMF

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Section: Discussionmentioning

confidence: 94%

“…Apparently, two reaction pathways are required to explain the two products observed in macroelectrolyses. Reaction [3] is shown as simple…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: IVmentioning

confidence: 99%

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The Electroreduction of Beta-Aminoethyl Mercurials

Wagenknecht¹

1972

J. Electrochem. Soc.

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“…The zinc (II) and copper (II) complexes spectra exhibited a red shift by about 10–18 nm to 275 and 268 nm. A redshift stipulates that the energy of the π‐π* transition decreases because of metal chelating 25 . The ligand‐to‐metal charge transfer transition (LMCT) band was observed in the zinc (II) and copper (II) complexes spectra at 418 and 415 nm 26 .…”

Section: Resultsmentioning

confidence: 99%

Synthesis of new Cu (II) and Zn (II) complexes derived from isatin‐3‐thiosemicarbazone: X‐ray, anticancer activity, molecular docking, ADMET study, and quantum chemical calculations

Mohamad Rodzi,

Mohd Tajuddin,

Sirat

et al. 2023

Applied Organom Chemis

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The current work aimed to synthesize new mononuclear Cu (II) and Zn (II) complexes derived from isatin‐based thiosemicarbazide, (Z)‐N‐methyl‐2‐(2‐oxoindolin‐3‐ylidene)hydrazinecarbothioamide ligand (L1) using the reflux conventional method. Structural characterization for the synthesized compounds was achieved via elemental analyses, spectroscopic analysis, magnetic susceptibility, molar conductivity, and thermal analysis. The compounds were further explored for their prospective anticancer properties with the aid of in silico methodology. Complexation of metal centers with L1 was observed using the shifting of the v(C=N) peak to lower frequencies and the emergence of new peaks in the range of 454–512 cm−1 assigned to v(M‐N) and v(M‐O). The non‐electrolytic character of Cu2+ and Zn2+ compounds was displayed by their low molar conductivities. Quantum chemical calculations were employed to investigate the electronic and molecular properties of the complexes. The frontier molecular orbitals were performed by density functional theory (DFT) calculations to provide valuable information regarding their molecular orbitals, reactivity indices, and electronic structures, assisting in understanding their structure–activity relationships and potential mechanisms of action. Additionally, molecular docking was carried out to comprehend the interaction of the compounds with the selected enzyme and determine their potential binding mode and energy. Meanwhile, the ADMET study exhibited that all of the compounds possess good oral bioavailability suggesting potent and suitable anticancer drug candidates. All the compounds were tested against human leukemia K562 cancer cell line and human fibroblasts Hs27 cell line. Overall, this comprehensive study highlights the synthesis, characterization, anticancer activity, molecular docking, ADMET evaluation, and quantum chemical calculations of new Cu (II) and Zn (II) complexes derived from isatin‐3‐thiosemicarbazone.

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Oscillographic Polarography

Gajan¹

1972

Physical Methods

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Organic polarography

Cited by 8 publications

References 179 publications

The Electroreduction of Beta-Aminoethyl Mercurials

The Electroreduction of Beta-Aminoethyl Mercurials

Synthesis of new Cu (II) and Zn (II) complexes derived from isatin‐3‐thiosemicarbazone: X‐ray, anticancer activity, molecular docking, ADMET study, and quantum chemical calculations

Oscillographic Polarography

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