Organic Photodynamic Nanoinhibitor for Synergistic Cancer Therapy

Jiang, Yuyan; Li, Jingchao; Zeng, Ziling; Xie, Chen; Lyu, Yan; Pu, Kanyi

doi:10.1002/anie.201903968

Cited by 192 publications

(101 citation statements)

References 35 publications

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“…Because ultraviolet (UV) or visible light shows shallow tissue penetration depth and has high photon energy that will lead to photodamage, near‐infrared (NIR) light (700–1000 nm) that penetrates deeper into tissues and induces minimal detriments is preferred . NIR light thus can be utilized for molecular imaging, such as afterglow imaging and photoacoustic imaging, phototherapy including photodynamic therapy (PDT), photothermal therapy, and photoimmunotherapy, photoactivation of prodrugs or proinhibitors, and photoregulation of biological events, such as gene expression, enzymatic activity, neural activity, biocatalysis, and so on. However, NIR light‐mediated photoinhibition of intracellular protein biosynthesis has been rarely exploited for cancer therapy.…”

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confidence: 99%

Near‐Infrared Photoactivatable Semiconducting Polymer Nanoblockaders for Metastasis‐Inhibited Combination Cancer Therapy

et al. 2019

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Inhibition of protein biosynthesis is a promising strategy to develop new therapeutic modalities for cancers; however, noninvasive precise regulation of this cellular event in living systems has been rarely reported. In this study, a semiconducting polymer nanoblockader (SPNB) is developed that can inhibit intracellular protein synthesis upon near‐infrared (NIR) photoactivation to synergize with photodynamic therapy (PDT) for metastasis‐inhibited cancer therapy. SPNB is self‐assembled from an amphiphilic semiconducting polymer which is grafted with poly(ethylene glycol) conjugated with a protein biosynthesis blockader through a singlet oxygen (1O2) cleavable linker. Such a designed molecular structure not only enables generation of 1O2 under NIR photoirradiation for PDT, but also permits photoactivation of blockaders to terminate protein translation. Thereby, SPNB exerts a synergistic action to afford an enhanced therapeutic efficacy in tumor ablation. More importantly, SPNB‐mediated photoactivation of protein synthesis inhibition precisely and remotely downregulates the expression levels of metastasis‐related proteins in tumor tissues, eventually contributing to the complete inhibition of lung metastasis. This study thus proposes a photoactivatable protherapeutic design for metastasis‐inhibited cancer therapy.

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confidence: 99%

Near‐Infrared Photoactivatable Semiconducting Polymer Nanoblockaders for Metastasis‐Inhibited Combination Cancer Therapy

et al. 2019

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“…The generation of O 2 could relieve the hypoxia of bacterial biofilm-infected tissues and may further enhance the efficacy of oxygen-dependent aPDT. Therefore, the singlet oxygen ( 1 O 2 ) production of MBP-Ce6 NSs in hypoxic conditions with the presence of H 2 O 2 was measured and evaluated by using 2 ′ ,7 ′ -dichlorodihydrofluorescein diacetate (DCFH-DA) as the fluorescent reactive oxygen species (ROS) indicator [52][53][54]. As shown in Figure S7…”

Section: Researchmentioning

confidence: 99%

Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections

et al. 2020

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The formation of bacterial biofilms closely associates with infectious diseases. Until now, precise diagnosis and effective treatment of bacterial biofilm infections are still in great need. Herein, a novel multifunctional theranostic nanoplatform based on MnO2 nanosheets (MnO2 NSs) has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy (aPDT) of bacterial biofilm infections. In this study, MnO2 NSs were modified with bovine serum albumin (BSA) and polyethylene glycol (PEG) and then loaded with chlorin e6 (Ce6) as photosensitizer to form MnO2-BSA/PEG-Ce6 nanosheets (MBP-Ce6 NSs). After being delivered into the bacterial biofilm-infected tissues, the MBP-Ce6 NSs could be decomposed in acidic biofilm microenvironment and release Ce6 with Mn2+, which subsequently activate both fluorescence (FL) and magnetic resonance (MR) signals for effective dual-mode FL/MR imaging of bacterial biofilm infections. Meanwhile, MnO2 could catalyze the decomposing of H2O2 in biofilm-infected tissues into O2 and relieve the hypoxic condition of biofilm, which significantly enhances the efficacy of aPDT. An in vitro study showed that MBP-Ce6 NSs could significantly reduce the number of methicillin-resistant Staphylococcus aureus (MRSA) in biofilms after 635 nm laser irradiation. Guided by FL/MR imaging, MRSA biofilm-infected mice can be efficiently treated by MBP-Ce6 NSs-based aPDT. Overall, MBP-Ce6 NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm, which provides a promising theranostic nanoplatform for bacterial biofilm infections.

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“…Further, the singlet oxygen generation ability of ICG@FeD and ICG@FeDH is further evaluated by SOSG. The uorescent intensity enhancement (F/F 0 ) is calculated according to the previously reported method [53,54]. The value of F/F 0 for ICG@FeDH and ICG@FeD is determined to be 3.82 and 3.79 ( Figure S4), respectively, suggesting that the modi cation of HA would not affect the singlet oxygen generation ability of ICG.…”

Section: In Vitro Photodynamic Effect Of Icg@fedhmentioning

confidence: 99%

Hyaluronic acid modified covalent organic polymers for efficient targeted and oxygen-evolved phototherapy

Shu

Yang

Zhang

et al. 2020

Preprint

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The integration of multiple functions with organic polymers-based nanoagent holds great potential to potentiate its therapeutic efficacy, but still remains challenges. In the present study, we design and prepare an organic nanoagent with oxygen-evolved and targeted ability for improved phototherapeutic efficacy. The iron ions doped poly diaminopyridine (FeD) is prepared by oxidize polymerization and modified with hyaluronic acid (HA). The obtained FeDH appears uniform morphology and size. Its excellent colloidal stability and biocompatibility are demonstrated. Specifically, the FeDH exhibits catalase-like activity in the presence of hydrogen peroxide. After loading of photosensitizer indocyanine green (ICG), the ICG@FeDH not only demonstrates favorable photothermal effect, but also shows improved generation ability of reactive oxygen species (ROS) under near-infrared laser irradiation. Moreover, the targeted uptake of ICG@FeDH in tumor cells is directly observed. As consequence, the superior phototherapeutic efficacy of the targeted ICG@FeDH over non-targeted counterparts is also confirmed in vitro and in vivo. Hence, the results demonstrate that the developed nanoagent rationally integrates the targeted ability, oxygen-evolved capacity and combined therapy in one system, offering a new paradigm of polymer-based nanomedicine for tumor therapy.

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Organic Photodynamic Nanoinhibitor for Synergistic Cancer Therapy

Cited by 192 publications

References 35 publications

Near‐Infrared Photoactivatable Semiconducting Polymer Nanoblockaders for Metastasis‐Inhibited Combination Cancer Therapy

Near‐Infrared Photoactivatable Semiconducting Polymer Nanoblockaders for Metastasis‐Inhibited Combination Cancer Therapy

Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections

Hyaluronic acid modified covalent organic polymers for efficient targeted and oxygen-evolved phototherapy

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