Organic Nanocrystals of the Resorcinarene Hexamer via Sonochemistry: Evidence of Reversed Crystal Growth Involving Hollow Morphologies

Sander, John; Bučar, Dejan‐Krešimir; Baltrušaitis, Jonas; MacGillivray, Leonard R.

doi:10.1021/ja211141p

Cited by 37 publications

(33 citation statements)

References 40 publications

(89 reference statements)

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“…Nanosized hollow rhombic-dodecahedral crystals of the C-methylcalix [4]resorcinarene hexamer were achieved with rapid nucleation of a crystalline phase. 75 The mechanism for the formation of the hollow organic crystals is attributed to a reversed crystal growth mechanism heretofore described only in the synthesis of inorganic-based materials. Broadly speaking, ultrasonic spray pyrolysis (USP) might also be regarded as an example of using physical effects of ultrasound for materials synthesis.…”

Section: à2mentioning

confidence: 99%

Sonochemical synthesis of nanomaterials

2013

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High intensity ultrasound can be used for the production of novel materials and provides an unusual route to known materials without bulk high temperatures, high pressures, or long reaction times.Several phenomena are responsible for sonochemistry and specifically the production or modification of nanomaterials during ultrasonic irradiation. The most notable effects are consequences of acoustic cavitation (the formation, growth, and implosive collapse of bubbles), and can be categorized as primary sonochemistry (gas-phase chemistry occurring inside collapsing bubbles), secondary sonochemistry (solution-phase chemistry occurring outside the bubbles), and physical modifications (caused by high-speed jets or shock waves derived from bubble collapse). This tutorial review provides examples of how the chemical and physical effects of high intensity ultrasound can be exploited for the preparation or modification of a wide range of nanostructured materials.

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Section: à2mentioning

confidence: 99%

Sonochemical synthesis of nanomaterials

2013

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“…Instead, they underwent aggregation to form polycrystalline particles with a rhombohedral appearance (Figure 7d). Despite the short history of this reversed crystal growth route it has been used to explain the formation of many hollow and core-shell crystals in several inorganic systems including zeolites [48,74,75], perovskites [76], metal oxides [26,77], plus more recently organic resorcinarene hexamer [78], alloy nanoparticles [79] and metal organic frameworks [80,81]. There is a need for further extensive studies on the complex interactions between organic structure directing agents and metal cations to establish the role EPS plays in biomineralisation.…”

Section: Formation Mechanismmentioning

confidence: 99%

Reversed Crystal Growth of Calcite in Naturally Occurring Travertine Crust

2017

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Abstract:A microstructural investigation by electron microscopy on a travertine specimen collected from Munigou National Park, Sichuan Province, China revealed evidence of a non-classical reversed crystal growth route previously only discovered in synthetic materials. Examination of the travertine specimen suggests that the presence of organic matter initiates the oriented aggregation of calcite nanocrystallites. Surface re-crystallisation of the aggregates leads to a single crystalline rhombohedral shell with a polycrystalline core. This core-shell structure carries a strong resemblance to synthetic calcite prepared in the presence of chitosan, where the growth of calcite was found to follow the so-called reversed crystal growth process. It is proposed that the similar roles of biomolecules in naturally occurring travertine and chitosan in the synthetic system are based on their isoelectric points and the polymerizable property of long chain chemical structures. This study is important so that the structural similarities between naturally occurring biominerals and biomimetic materials can be further understood.

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“…The current demand for micro/nano-material various applications in medical and pharmaceutical industry especially in drug delivery has triggered the research in organic crystal engineering and development (3,4). Crystal engineering is particularly important for the development of pharmaceutical molecules in the context of improved drug delivery or bio-labelling/bio-sensing (5,6).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures

et al. 2016

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Abstract.This study elucidates the physical properties of sono-crystallised micro/nano-sized acetaminophen/paracetamol (PMOL) and monitors its possible transformation from polymorphic form I (monoclinic) to form II (orthorhombic). Hydrophilic Plasdone® S630 copovidone (S630), N-vinyl-2-pyrrolidone and vinyl acetate copolymer, and methacrylate-based cationic copolymer, Eudragit® EPO (EPO), were used as polymeric carriers to prepare drug/polymer binary mixtures. Commercially available PMOL was crystallised under ultra sound sonication to produce micro/nano-sized (0.2-10 microns) crystals in monoclinic form. Homogeneous binary blends of drug-polymer mixtures at various drug concentrations were obtained via a thorough mixing. The analysis conducted via the single X-ray crystallography determined the detailed structure of the crystallised PMOL in its monoclinic form. The solid state and the morphology analyses of the PMOL in the binary blends evaluated via differential scanning calorimetry (DSC), modulated temperature DSC (MTDSC), scanning electron microscopy (SEM) and hot stage microscopy (HSM) revealed the crystalline existence of the drug within the amorphous polymeric matrices. The application of temperature controlled X-ray diffraction (VTXRPD) to study the polymorphism of PMOL showed that the most stable form I (monoclinic) was altered to its less stable form II (orthorhombic) at high temperature (>112°C) in the binary blends regardless of the drug amount. Thus, VTXRD was used as a useful tool to monitor polymorphic transformations of crystalline drug (e.g. PMOL) to assess their thermal stability in terms of pharmaceutical product development and research.

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Organic Nanocrystals of the Resorcinarene Hexamer via Sonochemistry: Evidence of Reversed Crystal Growth Involving Hollow Morphologies

Cited by 37 publications

References 40 publications

Sonochemical synthesis of nanomaterials

Sonochemical synthesis of nanomaterials

Reversed Crystal Growth of Calcite in Naturally Occurring Travertine Crust

RETRACTED ARTICLE: Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures

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