Organic Nanocarriers for the Delivery of Antiinfective Agents

Sobczyński, Jan; Chudzik-Rząd, Beata

doi:10.1016/b978-0-323-46152-8.00016-0

Cited by 1 publication

(1 citation statement)

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“…Numerous factors are decisive for the mucoadhesive properties of polysaccharides, such as molecular weight, viscosity, concentration, pH, and other characteristics of the polymer chain, which involve length, conformation, degree of cross-linking, and flexibility [113,114]. The charge and degree of ionization of the polymer are also very important factors that influence the mucoadhesion strength, and anionic polymers have greater mucoadhesion strength [114].…”

Section: Biological Assays 271 Ex Vivo Mucoadhesivenessmentioning

confidence: 99%

Biopolymer from Water Kefir as a Potential Clean-Label Ingredient for Health Applications: Evaluation of New Properties

et al. 2022

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The present work aimed to characterize the exopolysaccharide obtained from water kefir grains (EPSwk), a symbiotic association of probiotic microorganisms. New findings of the technological, mechanical, and biological properties of the sample were studied. The EPSwk polymer presented an Mw of 6.35 × 105 Da. The biopolymer also showed microcrystalline structure and characteristic thermal stability with maximum thermal degradation at 250 °C. The analysis of the monosaccharides of the EPSwk by gas chromatography demonstrated that the material is composed of glucose units (98 mol%). Additionally, EPSwk exhibited excellent emulsifying properties, film-forming ability, a low photodegradation rate (3.8%), and good mucoadhesive properties (adhesion Fmax of 1.065 N). EPSwk presented cytocompatibility and antibacterial activity against Escherichia coli and Staphylococcus aureus. The results of this study expand the potential application of the exopolysaccharide from water kefir as a potential clean-label raw material for pharmaceutical, biomedical, and cosmetic applications.

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Section: Biological Assays 271 Ex Vivo Mucoadhesivenessmentioning

confidence: 99%