Organic-Molecule-Based Fluorescent Chemosensor for Nerve Agents and Organophosphorus Pesticides

Gori, Muskan; Thakur, Ashima; Sharma, Abha; Flora, S.J.S.

doi:10.1007/s41061-021-00345-7

“…Complex 17 with biimidazole ligands showed good performance in pH sensing with the protonation-deprotonation mechanism [116]. In a recent study, the biimidazole-coupled phen ligand was employed as the binding site for the development of Ru(II) complex chemosensor (23) for Cu 2+ detection by Li and co-workers [121]. The coordination (1:1 bonding ratio) of Cu 2+ with complex 23's biimidazole led to the formation of a stable cyclic structure.…”

Section: Ru(ii) Complex Chemosensors For Cu 2+mentioning

confidence: 99%

“…Chemosensors are one of the most important tools for luminescence bioassay and imaging of small biomolecules and ions in situ in real time [21][22][23]. Luminescent chemosensors are normally designed as chemical compounds that can respond to targeted analytes through a unique binding/reaction (Fig.…”

Section: Introductionmentioning

confidence: 99%

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

Wu

¹

,

Zhang

²

,

Yong

³

et al. 2022

Metal Ligand Chromophores for Bioassays

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Luminescence chemosensors are one of the most useful tools for the determination and imaging of small biomolecules and ions in situ in real time. Based on the unique photo-physical/-chemical properties of ruthenium(II) (Ru(II)) complexes, the development of Ru(II) complex-based chemosensors has attracted increasing attention in recent years, and thus many Ru(II) complexes have been designed and synthesized for the detection of ions and small biomolecules in biological and environmental samples. In this work, we summarize the research advances in the development of Ru(II) complex-based chemosensors for the determination of ions and small biomolecules, including anions, metal ions, reactive biomolecules and amino acids, with a particular focus on binding/reaction-based chemosensors for the investigation of intracellular analytes’ evolution through luminescence analysis and imaging. The advances, challenges and future research directions in the development of Ru(II) complex-based chemosensors are also discussed.

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“…Chemosensors are one of the most important tools for luminescence bioassay and imaging of small biomolecules and ions in situ in real time [ 21 – 23 ]. Luminescent chemosensors are normally designed as chemical compounds that can respond to targeted analytes through a unique binding/reaction (Fig.…”

Section: Introductionmentioning

confidence: 99%

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

Wu

¹

,

Zhang

²

,

Yong

³

et al. 2022

View full text Add to dashboard Cite

Luminescence chemosensors are one of the most useful tools for the determination and imaging of small biomolecules and ions in situ in real time. Based on the unique photo-physical/-chemical properties of ruthenium(II) (Ru(II)) complexes, the development of Ru(II) complex-based chemosensors has attracted increasing attention in recent years, and thus many Ru(II) complexes have been designed and synthesized for the detection of ions and small biomolecules in biological and environmental samples. In this work, we summarize the research advances in the development of Ru(II) complex-based chemosensors for the determination of ions and small biomolecules, including anions, metal ions, reactive biomolecules and amino acids, with a particular focus on binding/reaction-based chemosensors for the investigation of intracellular analytes’ evolution through luminescence analysis and imaging. The advances, challenges and future research directions in the development of Ru(II) complex-based chemosensors are also discussed.

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“…To date, a large number of fluorescent sensors for pesticide detection have been reported, − and most of them can fall into two major categories (Figure a). For the enzyme assay, the pesticide serves as the substrate (or inhibitor) to initiate/inhibit an enzymatic reaction, which triggers the fluorescence change of the sensor . The limitation of this assay is a narrow scope of application only to the pesticides that act upon enzymes, such as carbamates and organophosphorus pesticides.…”

mentioning

confidence: 99%

“…For the enzyme assay, the pesticide serves as the substrate (or inhibitor) to initiate/ inhibit an enzymatic reaction, which triggers the fluorescence change of the sensor. 16 The limitation of this assay is a narrow scope of application only to the pesticides that act upon enzymes, such as carbamates and organophosphorus pesticides. Another assay, called indicator displacement assay (IDA), 17 is based on a supramolecular ensemble composed of a dye guest that can reversibly bind to a synthetic host.…”

mentioning

confidence: 99%

General Method for Pesticide Recognition Using Albumin-Based Host–Guest Ensembles

Qin

¹

,

Zhao

²

,

Lv

³

et al. 2022

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The massive use of pesticides nowadays has led to serious consequences for the environment and public health. Fluorescence analytical methods for pesticides are particularly advantageous with respect to simplicity and portability; however, currently available fluorescence methods (enzyme-based assays and indicator displacement assays) with poor universality are only able to detect few specific pesticides (e.g., organophosphorus). Making use of the multiple flexible and asymmetrical binding sites in albumin, we herein report a set of multicolor albumin-based host−guest ensembles. These ensembles exhibit a universal but distinctive fluorescent response to most of the common pesticides and allow array-based identification of pesticides with high accuracy. Furthermore, the simplicity, portability, and visualization of this method enable on-site determination of pesticides in a practical setting. This albumin host strategy largely expands the toolbox of traditional indicator displacement assays (synthetic macrocycles as hosts), and we expect it to inspire a series of sensor designs for pesticide detection.

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Organic-Molecule-Based Fluorescent Chemosensor for Nerve Agents and Organophosphorus Pesticides

Cited by 19 publications

References 84 publications

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

General Method for Pesticide Recognition Using Albumin-Based Host–Guest Ensembles

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