Organic–inorganic shape memory thermoplastic polyurethane based on polycaprolactone and polydimethylsiloxane

Chan, Benjamin Qi Yu; Liow, Sing Shy; Loh, Xian Jun

doi:10.1039/c6ra04041a

Cited by 42 publications

(37 citation statements)

References 61 publications

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“…The synthesis of the urethane-based thermogelling copolymers in this work is generally similar to previous work done by our group [49,50,51,52,53]. Typically, 4 g of PEG ( M n = 2050, 2.0 × 10 −3 mol), 2 g of PPG ( M n = 2000, 1.0 × 10 −3 mol) and 0.6 g of PTHF-diol ( M n = 2000, 0.3 × 10 −3 mol) were dissolved in anhydrous toluene at 60 °C.…”

Section: Methodssupporting

confidence: 72%

Poly(carbonate urethane)-Based Thermogels with Enhanced Drug Release Efficacy for Chemotherapeutic Applications

et al. 2018

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Abstract:In this study, we report the synthesis and characterisation of a thermogelling poly(carbonate urethane) system comprising poly(ethylene glycol) (PEG), poly(propylene glycol) (PPG) and poly(polytetrahydrofuran carbonate) (PTHF carbonate). The incorporation of PTHF carbonate allowed for the control of the lower critical solution temperature (LCST) and decreased critical gelation concentration (CGC) of the thermogels significantly. In addition, the as-prepared thermogels displayed low toxicity against HepG2, L02 and HEK293T cells. Drug release studies were carried out using doxorubicin (Dox). Studies conducted using nude mice models with hepatocellular carcinoma revealed that the Dox-loaded poly(PEG/PPG/PTHF carbonate urethane) thermogels showed excellent in vivo anti-tumour performance and effectively inhibited tumour growth in the tested model.

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Section: Methodssupporting

confidence: 72%

Poly(carbonate urethane)-Based Thermogels with Enhanced Drug Release Efficacy for Chemotherapeutic Applications

et al. 2018

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“…The T m was used as the trigger temperature for shape recovery thus achieving a T m close to the human body temperature which is very desirable for material intended to be used as biomedical material. The obtained result is consistent with a previous study, where the fabricated shape memory polymer showed a similar T m around 38 °C [ 13 ].…”

Section: Resultssupporting

confidence: 92%

“…The copolymer solutions were prepared at 10 wt% (w/w) diluted in HFIP and electro-spun at 10 kV. In general, with an appropriate polymer concentration, polymers with M n > 10,000 will form continuous fibres during the electrospinning process [ 13 ]. Referring to Table 1 , all the synthesized PCL–PDMS copolymer demonstrated M n > 10,000 which is within the expected electrospinning fibre-forming range.…”

Section: Resultsmentioning

confidence: 99%

“…The shape fixity of the copolymer nanofibres was lower in the first cycle because of the segment-chain orientation and relaxation effects [ 17 , 18 ]. As such, the shape memory nanofibres should be pre-conditioned to fully utilise the shape memory potential [ 13 , 17 , 18 ]. For subsequent cycles, the shape fixity of all samples surpassed 90%.…”

Section: Resultsmentioning

confidence: 99%

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Development of Thermo-Responsive Polycaprolactone–Polydimethylsiloxane Shrinkable Nanofibre Mesh

et al. 2020

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A thermally activated shape memory polymer based on the mixture of polycaprolactone (PCL) and polydimethylsiloxane (PDMS) was fabricated into the nanofibre mesh using the electrospinning process. The added percentages of the PDMS segment in the PCL-based polymer influenced the mechanical properties. Polycaprolactone serves as a switching segment to adjust the melting temperature of the shape memory electro-spun PCL–PDMS scaffolds to our body temperature at around 37 °C. Three electro-spun PCL–PDMS copolymer nanofibre samples, including PCL6–PDMS4, PCL7–PDMS3 and PCL8–PDMS2, were characterised to study the thermal and mechanical properties along with the shape memory responses. The results from the experiment showed that the PCL switching segment ratio determines the crystallinity of the copolymer nanofibres, where a higher PCL ratio results in a higher degree of crystallinity. In contrast, the results showed that the mechanical properties of the copolymer samples decreased with the PCL composition ratio. After five thermomechanical cycles, the fabricated copolymer nanofibres exhibited excellent shape memory properties with 98% shape fixity and above 100% recovery ratio. Moreover, biological experiments were applied to evaluate the biocompatibility of the fabricated PCL–PDMS nanofibre mesh. Owing to the thermally activated shape memory performance, the electro-spun PCL–PDMS fibrous mesh has a high potential for biomedical applications such as medical shrinkable tubing and wire.

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“…Thermoplastic shape-memory polyurethanes (SMPURs) with tunable thermal and mechanical properties have been widely investigated as they are well suited for a broad variety of processing methods. [1][2][3] SMPUR are characterized by a phase-segregated structure, in which the switching domains act as temporary netpoints, and hard domains determine the permanent shape. SMPURs provide a high deformability but exhibit low shape recovery.…”

Section: Introductionmentioning

confidence: 99%

Poly(carbonate‐urea‐urethane) networks exhibiting high‐strain shape‐memory effect

Mazurek-Budzyńska

Razzaq

Tomczyk

et al. 2016

Polymers for Advanced Techs

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A challenge in the design of shape‐memory polymers (SMPs) is to achieve high deformability with a simultaneous high shape recovery ratio. Here we explored, whether SMPs featuring large deformation capability and high shape recovery ratios can be created as polymer networks providing two kinds of netpoints based on covalent bonds and physical interactions. As a model system, we selected poly(carbonate‐urea‐urethane)s (PCUUs) synthesized by a precursor route, based on oligo(alkylene carbonate) diols, isophorone diisocyanate (IPDI), and water vapor. The PCUU networks exhibited a one‐way shape‐memory effect (1W‐SME) with programmed strains up to εprog = 1000% whereby they provided excellent shape fixity (92–97%) and shape recovery (≥99%) ratios. The switching temperatures (Tsw) varied between 36 and 65 °C and increased with the increasing molecular weight of the oligo(alkylene carbonate) diol and length of the hydrocarbon chain between the carbonate linkages. Tsw was also influenced by the strain applied during programming (εprog). Poly(carbonate‐urethane)s have been reported to have good biocompatibility and biostability, which in the combination of high‐strain capacity and high Young's modulus makes the obtained PCUUs interesting candidate materials suitable for medical devices such as medical sutures or vascular stents. Copyright © 2016 John Wiley & Sons, Ltd.

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Organic–inorganic shape memory thermoplastic polyurethane based on polycaprolactone and polydimethylsiloxane

Abstract: We report an organic–inorganic SMP comprising PCL and PDMS that exhibits extremely fast-response time at body temperature and thermoplasticity that allows for solvent processing. The SMP recovered to the programmed shape in less than 0.5 seconds.

Cited by 42 publications

References 61 publications

Poly(carbonate urethane)-Based Thermogels with Enhanced Drug Release Efficacy for Chemotherapeutic Applications

Poly(carbonate urethane)-Based Thermogels with Enhanced Drug Release Efficacy for Chemotherapeutic Applications

Development of Thermo-Responsive Polycaprolactone–Polydimethylsiloxane Shrinkable Nanofibre Mesh

Poly(carbonate‐urea‐urethane) networks exhibiting high‐strain shape‐memory effect

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