Organic fluorescent thermometers: Highlights from 2013 to 2017

Qin, Tianyi; Liu, Bin; Zhu, Kangning; Luo, Zijie; Huang, Yingying; Pan, Chengjun; Wang, Lei

doi:10.1016/j.trac.2018.03.003

Cited by 63 publications

(40 citation statements)

References 131 publications

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“…The use of fluorescent molecules whose emission intensity depends on the temperature is a frequent strategy for local thermometry 18 , 19 with several technological advantages with respect to other nanothermometry alternatives. 18 , 20 Fluorescent proteins, such as the superfolder Green Fluorescent Protein (sGFP) or m-Cherry Red Fluorescent Protein (RFP), can be genetically engineered to be tagged with a 6xHis polypetide at their N-terminus in order to resemble a typical site-directed orientation link between enzymes and MNPs functionalized with divalent transition-metal coatings. These proteins suffer an irreversible unfolding denaturation with temperature that leads to a linear loss of fluorescence.…”

Section: Introductionmentioning

confidence: 99%

Selective Magnetic Nanoheating: Combining Iron Oxide Nanoparticles for Multi-Hot-Spot Induction and Sequential Regulation

et al. 2021

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The contactless heating capacity of magnetic nanoparticles (MNPs) has been exploited in fields such as hyperthermia cancer therapy, catalysis, and enzymatic thermal regulation. Herein, we propose an advanced technology to generate multiple local temperatures in a single-pot reactor by exploiting the unique nanoheating features of iron oxide MNPs exposed to alternating magnetic fields (AMFs). The heating power of the MNPs depends on their magnetic features but also on the intensity and frequency conditions of the AMF. Using a mixture of diluted colloids of MNPs we were able to generate a multi-hot-spot reactor in which each population of MNPs can be selectively activated by adjusting the AMF conditions. The maximum temperature reached at the surface of each MNP was registered using independent fluorescent thermometers that mimic the molecular link between enzymes and MNPs. This technology paves the path for the implementation of a selective regulation of multienzymatic reactions.

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Section: Introductionmentioning

confidence: 99%

Selective Magnetic Nanoheating: Combining Iron Oxide Nanoparticles for Multi-Hot-Spot Induction and Sequential Regulation

et al. 2021

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“…Fluorescent temperature probes have the advantages of ultra-high sensitivity, fast response, high spatial resolution, safe, and noninvasive detection signal. Different kinds of fluorescent thermometers have been developed (Wang et al, 2013;Li et al, 2014;Wu1 et al, 2017;Qin et al, 2018;Kniec et al, 2019;Gao et al, 2020;Meng et al, 2020;Back et al, 2021;Wang et al, 2021). However, conventional fluorescent thermometers are sensitive only in a narrow temperature range, which limits their application to a certain degree.…”

Section: Unusual and Sensitivementioning

confidence: 99%

Optical Characteristics and Applications of AIE Racemic C6-Unsubstituted Tetrahydropyrimidines

Zhu

2021

Front. Chem.

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Racemic C6-unsubstituted tetrahydropyrimidines (THPs) are the products of an efficient five-component reaction that we developed. THPs show strong AIE characteristics, that is, completely no fluorescence in different solvents but strong emission with fluorescence quantum yields (ΦF) up to 100% upon aggregation. However, the ΦF values of their pure enantiomers are lower than 46%. Unlike common AIE compounds with crowded aryl rotors on a π-bond or on an aryl ring, THPs have three completely non-crowded aryl rotors on a non-aromatic chiral central ring (tetrahydropyrimidine). In this mini review, we first discuss the AIE characteristics of THPs and the influences of molecular structures on their molecular packing modes and optical properties, and then present their applications and forecast the development of other racemic AIE compounds.

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“…While the field of reported luminescent temperature sensing systems, [ 16,19 ] even down to the scale of a single living cell (luminescence nanothermometry), [ 20 ] is enormous in its variety, the field of luminescent temperature recorders, reacting with an irreversible signal response to specific temperature influence, is more narrow. Reversible luminescent temperature probes, i.e., sensors, typically utilize the omnipresent temperature dependence of the specific electronic band structure of materials.…”

Section: Introductionmentioning

confidence: 99%

Communicating Particles: Identification Taggant and Temperature Recorder in One Single Supraparticle

Reichstein

Miller

Wintzheimer

et al. 2021

Adv Funct Materials

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“Communicating particles” are reported that combine an identification (ID) taggant and a temperature recorder in one single entity—a micron‐scaled supraparticle. The optical information carriers within the hybrid inorganic‐organic supraparticles are three different types of luminescent nanoparticles, which can be read‐out using single‐wavelength excitation. These three nanoparticle types are assembled into a core‐satellite structure via a two‐step droplet evaporation technique. The core is built‐up from Tb3+ and Eu3+‐doped nanophosphors, providing an environmentally stable ID that is easily tunable through ratiometric spectral coding. This core is surrounded by organic, dye‐doped polymer nanoparticle satellites, acting as thermal‐history‐recorders of their environment. Exposed to a threshold temperature, the luminescence of the utilized 7‐diethylamino‐4‐methylcoumarin‐doped polymer nanoparticles is irreversibly quenched. This “turn‐off ” signal response is attributed to conformational changes in the dyes’ excited state and an alteration of their molecular environment, respectively, triggered by the polymer nanoparticles’ glass transition. Thus, the sensitivity of the temperature recorder can be configured over a wide temperature range by varying the dye‐hosting polymer. At the same time, the ID of the particle, stemming from its inorganic building blocks, stays unaffected, thus stable against thermal changes. The idea of communicating particles introduces a promising concept for smart additives.

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Organic fluorescent thermometers: Highlights from 2013 to 2017

Cited by 63 publications

References 131 publications

Selective Magnetic Nanoheating: Combining Iron Oxide Nanoparticles for Multi-Hot-Spot Induction and Sequential Regulation

Selective Magnetic Nanoheating: Combining Iron Oxide Nanoparticles for Multi-Hot-Spot Induction and Sequential Regulation

Optical Characteristics and Applications of AIE Racemic C6-Unsubstituted Tetrahydropyrimidines

Communicating Particles: Identification Taggant and Temperature Recorder in One Single Supraparticle

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