Organic electrochemical transistors in bioelectronic circuits

Rashid, Reem B.; Ji, Xudong; Rivnay, Jonathan

doi:10.1016/j.bios.2021.113461

Cited by 73 publications

(61 citation statements)

References 121 publications

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“…Material characteristics and preparation process of each type of semiconductor materials and their inverter performances were listed up in Tables 3 and 4. Complementary inverters possess significant potential for application to not only logic components but also various sensors (such as chemical sensors [124,125], optical sensors [126], gas sensors [127], and temperature sensors [83]) and biomedical applications (such as bioelectronics [128,129] and bio-signal amplifiers [119,130]). However, challenges for integrating hybrid materials still exist; the fabrication process of p-type and n-type materials and their devices requires the separate deposition, patterning, and optimization of two heterogenous materials, increasing the complexity of the fabrication process with the ad hoc process conditions.…”

Section: Discussionmentioning

confidence: 99%

Hybrid Thin-Film Materials Combinations for Complementary Integration Circuit Implementation

2021

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Beyond conventional silicon, emerging semiconductor materials have been actively investigated for the development of integrated circuits (ICs). Considerable effort has been put into implementing complementary circuits using non-silicon emerging materials, such as organic semiconductors, carbon nanotubes, metal oxides, transition metal dichalcogenides, and perovskites. Whereas shortcomings of each candidate semiconductor limit the development of complementary ICs, an approach of hybrid materials is considered as a new solution to the complementary integration process. This article revisits recent advances in hybrid-material combination-based complementary circuits. This review summarizes the strong and weak points of the respective candidates, focusing on their complementary circuit integrations. We also discuss the opportunities and challenges presented by the prospect of hybrid integration.

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Section: Discussionmentioning

confidence: 99%

Hybrid Thin-Film Materials Combinations for Complementary Integration Circuit Implementation

2021

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“…Conductive polymers continue to be an active research topic for biomaterials and have demonstrated record tensile strains (>100%), low moduli (kPa-MPa), and conductivity (10 1 -10 4 S m -1 ), [578][579][580][581][582] among other tunable charac teristics such as anisotropy, [583] adhesiveness, [156,[584][585][586] and bio degradability. [587] A wide range of polymers are being explored as stretchable semiconductors, optimizing for charge car rier mobility, [587][588][589] device density, [590] ionic transport, [591] and neuromorphic computing.…”

Section: Other Conductorsmentioning

confidence: 99%

Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine

et al. 2022

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Designing bioelectronic devices that seamlessly integrate with the human body is a technological pursuit of great importance. Bioelectronic medical devices that reliably and chronically interface with the body can advance neuroscience, health monitoring, diagnostics, and therapeutics. Recent major efforts focus on investigating strategies to fabricate flexible, stretchable, and soft electronic devices, and advances in materials chemistry have emerged as fundamental to the creation of the next generation of bioelectronics. This review summarizes contemporary advances and forthcoming technical challenges related to three principal components of bioelectronic devices: i) substrates and structural materials, ii) barrier and encapsulation materials, and iii) conductive materials. Through notable illustrations from the literature, integration and device fabrication strategies and associated challenges for each material class are highlighted.

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“…Figure a shows the graphical illustration of an OECT and its working principle. [ 84 ] OECTs allow electrochemical energy conversion with a liquid‐gate, operate at low voltages (<1 V), show transconductance superior to most FETs, and offer new (bio)chemical sensing capabilities within picoliter sampling volumes. [ 85 ] PEDOT:PSS is most commonly used as the active layer of OECTs, because of its commercial availability and biocompatibility, chemical stability, as well as attainable processability.…”

Section: Advanced Sensing Systems and Devices For Monitoring Of Cell ...mentioning

confidence: 99%

Section: Monitoring Cells With Organic Electronicsmentioning

confidence: 99%

Advanced Materials and Sensors for Microphysiological Systems: Focus on Electronic and Electrooptical Interfaces

2022

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Advanced in vitro cell culture systems or microphysiological systems (MPSs), including microfluidic organ‐on‐a‐chip (OoC), are breakthrough technologies in biomedicine. These systems recapitulate features of human tissues outside of the body. They are increasingly being used to study the functionality of different organs for applications such as drug evolutions, disease modeling, and precision medicine. Currently, developers and endpoint users of these in vitro models promote how they can replace animal models or even be a better ethically neutral and humanized alternative to study pathology, physiology, and pharmacology. Although reported models show a remarkable physiological structure and function compared to the conventional 2D cell culture, they are almost exclusively based on standard passive polymers or glass with none or minimal real‐time stimuli and readout capacity. The next technology leap in reproducing in vivo‐like functionality and real‐time monitoring of tissue function could be realized with advanced functional materials and devices. This review describes the currently reported electronic and optical advanced materials for sensing and stimulation of MPS models. In addition, an overview of multi‐sensing for Body‐on‐Chip platforms is given. Finally, one gives the perspective on how advanced functional materials could be integrated into in vitro systems to precisely mimic human physiology.

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Organic electrochemical transistors in bioelectronic circuits

Cited by 73 publications

References 121 publications

Hybrid Thin-Film Materials Combinations for Complementary Integration Circuit Implementation

Hybrid Thin-Film Materials Combinations for Complementary Integration Circuit Implementation

Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine

Advanced Materials and Sensors for Microphysiological Systems: Focus on Electronic and Electrooptical Interfaces

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