Organic Compounds

Structure and activity relationships of platinum complexes related to antitumour activity: the crystal and molecular structure of trans-dichlorobis (cyclohexylamine)platinum(II)

“…In particular, the shortest Pt... Pt contacts (4.50 and 6.67 A) compare well with the distances found in the crystal structures of several Pt u complexes (Barnes, Iball & Weakley, 1975;Colamarino & Orioli, 1975;Lauher & Ibers, 1975). These values, however, are far longer than that of 3.40 ,/%, which has been reported for compounds where stacking occurs and which was assumed to be an indication of metal-metal interaction (Iball, MacDougall & Scrimgeour, 1975).…”

“…In particular, Pt-CI [2.302(2) A] and Pt-N [2.078 (5) A] are in good agreement with values reported for analogous compounds (Barnes, Iball & Weakley, 1975;Colamarino & Orioli, 1975;Iball, MacDougall & Scrimgeour, 1975;Lauher & Ibers, 1975). All C-H lengths are in the range 0.9-1.1 /~.…”

cis-Dichlorobis(cyclohexylamine-N)platinum(II)–bis(hexamethylphosphoramide)

“…The Pt-containing molecules are arranged so that they are hydrogen bonded into pairs related by the inversion centre at 1 0,~,: through N(1)--H... C1(2). The remaining H atoms on the amine groups are involved in bonding to the hexamethylphosphoramide groups through N (1) The hydrogen-bonded molecular-pair arrangement mentioned above, with about 3.4/k between the square planes, is very common in cis-diaminedichloroplatinum(II) complexes (Milburn & Truter, 1966;Lock & Zvagulis, 1980;Iball et al, 1975;Lock & Pilon, 1980) but has not been found in the corresponding trans complexes (Zanotti et al, 1978;Milburn & Truter, 1966). Srivastava, Froehlich & Eichhorn (1978) have suggested this as the basis for a model of the primary lesion in the anti-cancer activity of the Pt drugs.…”

The molecular and crystal structure of bis[2-(aminomethyl)pyridine]platinum(II) dichloride monohydrate

“…The refined atomic parameters are listed in (6) 1229 (4) 1201 (3) C (1) 3606 (8) 724 (4) 3924 (4) C (2) 2093 (8) 938 (4) 4239 (4) C (3) 2113 (9) 952 (5) 5240 (4) C (4) 630 (11) 1155 (6) 5436 ( (10) 1001 (11) 1467 (5) -1290 (5) C (11) 2514 (10) 1634 (5) -477 (5) C (12) 2429 (9) 1553 (4) 489 ( (Iball, MacDougall & Scrimgeour, 1975;Drew, Riedl & Rodgers, 1972;Melanson & Rochon, 1975).…”