Organic chemistry

Turner, E. E.; Hirst, E. L.; Peat, S.; Haworth, R. D.; Baker, W.; Linstead, R. P.; Cook, J. W.

doi:10.1039/ar9363300228

Cited by 7 publications

(11 citation statements)

References 2 publications

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“…Second, sulfur is a good reagent for dehydrogenation of organic compounds, the hydrogen being removed as H 2 S. One formerly used preparative method for H 2 S was the heating of sulfur with paraffin (Bloxam, 1913;Kleinberg et al, 1960). Among the other kinds of compounds known to be dehydrogenated with sulfur include abietic acid (Fieser and Fieser, 1944), butane (Rasmussen et al, 1946), cyclohexane (Szmant, 1957), methyldecalins (Cram and Hammond, 1964), various sesquiterpenes (Bordwell, 1963) (e.g., the conversion of cadinene to isocadinene and selinene to eudalene (Fieser and Fieser, 1944)), and tetralin (Turner et al, 1936;Fuson, 1950). A third reason for initially considering sulfur, though it later proved not to be important in our work, is that many of these dehydrogenation reactions proceed at comparatively low temperatures, usually below 300 8C, and typically 230-250 8C (Fieser and Fieser, 1957).…”

Section: Introductionmentioning

confidence: 98%

The use of sulfur to extract hydrogen from coal

Jusino

Schobert

2006

International Journal of Coal Geology

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Section: Introductionmentioning

confidence: 98%

The use of sulfur to extract hydrogen from coal

Jusino

Schobert

2006

International Journal of Coal Geology

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“…Lignans represent a large group of naturally occurring phenolic compounds, widely distributed within the plant kingdom. The term lignan originated from Haworth, 99 to describe a group of secondary plant metabolites, which molecular backbone consists of two phenylpropanoid (C6-C3) units. Lignans are phenylpropane dimers linked via β-β′ (8-8′) carbon atoms, with a different degree of oxidation in the side-chain and a different substitution pattern in the aromatic moieties.…”

Section: Lignansmentioning

confidence: 99%

Furofuran lignans of Artemisia genus: Isolation, biosynthesis and biological activity

Ickovski

Pavlović

Palić

et al. 2020

JSCS

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Since ancient times, medicinal plants and pharmacologically active products obtained from different natural sources play an important role in human health. Plants belonging to the genus Artemisia possess a great biological potential and it is a well-studied genus in the fields such as systematics (including molecular phylogenetics) and genome organization. Many species of the genus (e.g., A. absinthium, A. annua, A. vulgaris, A. abrotanum, A. arborescens) are widely exploited, because of their high economic value as medicines, food and ornamentals. Withal, in such a large genus, some hiatus must inevitably exist, concerning attainments and potentials that individual species possess. Most of the studies are focused on bioactivity and pharmacology of sesquiterpene lactones. Lignans are unjustly neglected, even though they as well exhibit a wide range of bioactivities. Motivated by that fact, we tried to consolidate findings on bioactive lignans accumulated through the years, with the logical perspectives on further work on isolation and identification of new bioactive lignans and the exploitation of lignans as substances of potential pharmacological interest.

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“…In 1936, Haworth was the first to describe a group of phenylpropanoid dimers (C 6 C 3 ) linked by the central carbon (C8) as lignans [8]. The Haworth's definition of lignan has been adopted by the IUPAC nomenclature recommendations in 2000 [9].…”

Section: Lignans and Their Biological Activitiesmentioning

confidence: 99%

Towards Metabolic Engineering of Podophyllotoxin Production

Seegers

Setroikromo²,

Quax

2017

Natural Products and Cancer Drug Discovery

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The pharmaceutically important anticancer drugs etoposide and teniposide are derived from podophyllotoxin, a natural product isolated from roots of Podophyllum hexandrum growing in the wild. The overexploitation of this endangered plant has led to the search for alternative sources. Metabolic engineering aimed at constructing the pathway in another host cell is very appealing, but for that approach, an in-depth knowledge of the pathway toward podophyllotoxin is necessary. In this chapter, we give an overview of the lignan pathway leading to podophyllotoxin. Subsequently, we will discuss the engineering possibilities to produce podophyllotoxin in a heterologous host. This will require detailed knowledge on the cellular localization of the enzymes of the lignan biosynthesis pathway. Due to the high number of enzymes involved and the scarce information on compartmentalization, the heterologous production of podophyllotoxin still remains a tremendous challenge. At the moment, research is focusing on the last step(s) in the conversion of deoxypodophyllotoxin to (epi)podophyllotoxin and 4′-demethyldesoxypodophyllotoxin by plant cytochromes.

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Organic chemistry

Cited by 7 publications

References 2 publications

The use of sulfur to extract hydrogen from coal

The use of sulfur to extract hydrogen from coal

Furofuran lignans of Artemisia genus: Isolation, biosynthesis and biological activity

Towards Metabolic Engineering of Podophyllotoxin Production

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