Organic bioelectronics in medicine

Löffler, Susanne; Melican, Keira; Nilsson, K. Peter R.; Richter‐Dahlfors, Agneta

doi:10.1111/joim.12595

Cited by 38 publications

(32 citation statements)

References 110 publications

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“…Finally, among the different bioelectrochemical approaches, it is worth mentioning that organic bioelectronics [98][99][100][101][102] is receiving great attention for its potential application in real-time selective noninvasive detection of chemical biomarkers, including drugs, metabolites, neurotransmitters, proteins, and hormones, in a variety of body fluids. The interactions of EGFR exon 21-point mutant gene with the anticancer drug Gemcitabine was recently evaluated using a DNA biosensor as reported in [82] and summarized in Table 3.…”

Section: Other Bioelectrochemical Approachesmentioning

confidence: 99%

Label-Free Bioelectrochemical Methods for Evaluation of Anticancer Drug Effects at a Molecular Level

Tadini‐Buoninsegni

Palchetti

2020

Sensors

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Cancer is a multifactorial family of diseases that is still a leading cause of death worldwide. More than 100 different types of cancer affecting over 60 human organs are known. Chemotherapy plays a central role for treating cancer. The development of new anticancer drugs or new uses for existing drugs is an exciting and increasing research area. This is particularly important since drug resistance and side effects can limit the efficacy of the chemotherapy. Thus, there is a need for multiplexed, cost-effective, rapid, and novel screening methods that can help to elucidate the mechanism of the action of anticancer drugs and the identification of novel drug candidates. This review focuses on different label-free bioelectrochemical approaches, in particular, impedance-based methods, the solid supported membranes technique, and the DNA-based electrochemical sensor, that can be used to evaluate the effects of anticancer drugs on nucleic acids, membrane transporters, and living cells. Some relevant examples of anticancer drug interactions are presented which demonstrate the usefulness of such methods for the characterization of the mechanism of action of anticancer drugs that are targeted against various biomolecules.

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Section: Other Bioelectrochemical Approachesmentioning

confidence: 99%

Label-Free Bioelectrochemical Methods for Evaluation of Anticancer Drug Effects at a Molecular Level

Tadini‐Buoninsegni

Palchetti

2020

Sensors

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“…The next generation of bioelectronics will require materials with tunable functionality that specifically addresses the requirements for an application, such as modulating mechanical softness for tissue engineering or providing a mixture of ionic and electronic conductivity for biosensing applications. [1][2][3] Organic electronic materials, notably conjugated polymers (CPs), offer many advantageous properties for bioelectronics; the most valuable being both ionic and electrical conductivity (when doped), ease of chemical functionalization, and solution processability through the addition of side chains. [4,5] For instance, side chain engineering of CPs has rendered the material's solubility to facilitate large-area fabrication of organic devices and sensors through solution-based processes.…”

Section: Conducting Polymersmentioning

confidence: 99%

Molecular “Building Block” and “Side Chain Engineering”: Approach to Synthesis of Multifunctional and Soluble Poly(pyrrole phenylene)s

Chan

Baek

Tan

et al. 2018

Macromol. Rapid Commun.

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Here, the synthesis of a novel poly(pyrrole phenylene) (PpyP) that is both modular in ways of functionalization and soluble in organic solvents is reported, and therefore solution processable. This is achieved through the functionalization of the side‐chain substituents in pyrrole phenylene (PyP) repeating units. t Butyl acrylate brushes are first grafted through atom transfer radical polymerization from one type of PyP, followed by oxidative chemical co‐polymerization of the grafted PyP with a PyP bearing different side chains—either an azide or a methoxy moiety, resulting in a soluble PpyP where solubility is not dopant‐dependent. Successful post‐polymerization modification through “click” chemistry and post‐polymerization processing via electrospinning are also demonstrated. Additionally, performed computational calculations indicate planarity of the novel polyrrole phenylene monomers and ionisation potentials that favor α–α bond formation during their polymerization.

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“…Synthetic biology's architecture parallels the hierarchical structure of electronics (Andrianantoandro et al, 2006), and areas of synthetic biology involve information processing such as the Gardner toggle switch (Gardner et al, 2000) and logic gates (Ausl€ ander et al, 2012;Bonnet et al, 2013;Siuti et al, 2013;Stanton et al, 2014;Stricker et al, 2008). Excellent reviews highlight both fields (Lö ffler et al, 2017;Simon et al, 2016;Someya et al, 2016;Strakosas et al, 2017b;Zhou et al, 2017). Synthetic biological approaches may lead to the next-generation electronic components and systems, including the ones developed as part of the recent NSF-SRC-IARPA Semiconductor Synthetic Biology for Information Processing and Storage Technologies (SemiSynBio) program.…”

Section: Introductionmentioning

confidence: 99%

“…Beginning with Galvani's studies on animal electricity (Galvani, 1972), bioelectronics has merged electronic devices with biology. A theme of bioelectronics is the use of electronic devices for the sensing and analysis of specific biological processes often relevant to health care (Fang et al, 2015;Lö ffler et al, 2017;Rivnay et al, 2014;Simon et al, 2016;Someya et al, 2016). Another theme is the use of electronic signals for treatment and curing of medical conditions.…”

Section: Introductionmentioning

confidence: 99%

The Potential for Convergence between Synthetic Biology and Bioelectronics

2018

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The fields of synthetic biology, which focuses on genetic and cellular substrates, and bioelectronics, which focuses on interfacing electronics with biology, may appear to have little in common on the surface. However, we contend that there is potential for convergence between the two fields based on shared and complementary design principles from each field. We provide examples where this convergence is beginning to take place in the engineered measurement and control of cell populations, individual cells, and membrane transport. We propose that as the convergence spreads, bioelectronics will enable real-time sensing and control of synthetic biological processes through integration with conventional electronics. The increased capabilities resulting from this convergence may broaden the scope and deepen the impact of both synthetic biology and bioelectronics.

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Organic bioelectronics in medicine

Abstract: Content List -Read more articles from the symposium: 13th Key Symposium -Bioelectronic Medicine: Technology Targeting Molecular Mechanisms.Abstract. L€ offler S, Melican K, Richter-Dahlfors A.

Cited by 38 publications

References 110 publications

Label-Free Bioelectrochemical Methods for Evaluation of Anticancer Drug Effects at a Molecular Level

Label-Free Bioelectrochemical Methods for Evaluation of Anticancer Drug Effects at a Molecular Level

Molecular “Building Block” and “Side Chain Engineering”: Approach to Synthesis of Multifunctional and Soluble Poly(pyrrole phenylene)s

The Potential for Convergence between Synthetic Biology and Bioelectronics

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