Organic Antimony Compounds Derived from s-Triazine with Therapeutic and Prophylactic Activity in Experimental Trypanosomiasis<sup>1</sup>

Friedheim, Ernst A. H.; Vogel, Henry J.; Berman, Rose L.

doi:10.1021/ja01195a028

Cited by 14 publications

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“…7 Sodium pmelaminylphenylstibonate exerts a prominent prophylactic effect in trypanosomiasis. 8 Vinson et al reported that arylstibonic acid derivatives are promising systems for inhibiting B-ZIP DNA binding and could be helpful as anticancer agents. 9 Similarly, arylstibonic acids act as potent inhibitors of apurinic/apyrimidinic endonuclease 1, 10 human topoisomerase IB (hTopo), 11 and protein tyrosine phosphatases 12 which have been used in the development of chemotherapeutic agents.…”

Section: ■ Introductionmentioning

confidence: 99%

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Discrete Molecular Aggregates Based on Zn^II and Sb^III/V Ions Displaying Efficient Antibacterial and Antioxidant Properties

et al. 2023

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The reactions of [Zn3Cl2(3,5-Me2PzH)4(t-BuPO3)2] with organostibonic acid in varying reaction conditions have been investigated. Single-crystal X-ray diffraction studies reveal the formation of [Zn2(p-ClC6H4Sb)2(O)2(OCH3)2(t-BuPO3)3(py)2] (1), [Zn2(p-ClC6H4SbV)4(SbIII)2(O)8(t-BuPO3H)4(t-BuPO3)2(py)2Cl2] (2), and [Zn2(RSb)4(O)4(OCH3)4(t-BuPO3)4(py)2], where R = p-ClC6H4 (3) and R = p-iPrC6H4 (4), respectively. Interestingly, in the synthesis of 2, complete dearylation of organoantimony moieties followed by C–F bond formation, a reduction from Sb (V) to Sb (III), and Sb···Cl weak intermolecular interactions have been observed. ESI-MS studies suggested that clusters 1–4 maintained their structural integrity in the solution state also. Solution NMR studies (1H, 31P, and 13C) support well the observed solid-state structures. 1–4 were tested for antibacterial activity using a microdilution assay. 1 and 4 showed the best activity with lower MIC values (0.78–6.25 μg/mL) against all the tested pathogens. The total antioxidant activity of 1–4 was evaluated through the phosphomolybdenum assay, which showed a total antioxidant activity ranging from 28.96 to 86.46 mg AAE/g compound with the ascorbic acid standard.

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Section: ■ Introductionmentioning

confidence: 99%

“…Organostibonic acids have exhibited potent anti-HIV activity; these compounds block the HIV-1 strains by disrupting the gp120 and CD4 contacts . Sodium p -melaminylphenylstibonate exerts a prominent prophylactic effect in trypanosomiasis . Vinson et al.…”

Section: Introductionmentioning

confidence: 99%

Discrete Molecular Aggregates Based on Zn^II and Sb^III/V Ions Displaying Efficient Antibacterial and Antioxidant Properties

et al. 2023

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Melamine and Substituted Melamines

1959

Chemistry of Heterocyclic Compounds: A Series of Monographs

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Organoantimony Compounds

Mirbach¹,

Krüerke²

1990

Sb Organoantimony Compounds Part 5

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Organic Antimony Compounds Derived from s-Triazine with Therapeutic and Prophylactic Activity in Experimental Trypanosomiasis¹

Cited by 14 publications

References 1 publication

Discrete Molecular Aggregates Based on Zn^II and Sb^III/V Ions Displaying Efficient Antibacterial and Antioxidant Properties

Discrete Molecular Aggregates Based on Zn^II and Sb^III/V Ions Displaying Efficient Antibacterial and Antioxidant Properties

Melamine and Substituted Melamines

Organoantimony Compounds

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Organic Antimony Compounds Derived from s-Triazine with Therapeutic and Prophylactic Activity in Experimental Trypanosomiasis1

Cited by 14 publications

References 1 publication

Discrete Molecular Aggregates Based on ZnII and SbIII/V Ions Displaying Efficient Antibacterial and Antioxidant Properties

Discrete Molecular Aggregates Based on ZnII and SbIII/V Ions Displaying Efficient Antibacterial and Antioxidant Properties

Melamine and Substituted Melamines

Organoantimony Compounds

Contact Info

Product

Resources

About

Organic Antimony Compounds Derived from s-Triazine with Therapeutic and Prophylactic Activity in Experimental Trypanosomiasis¹

Discrete Molecular Aggregates Based on Zn^II and Sb^III/V Ions Displaying Efficient Antibacterial and Antioxidant Properties

Discrete Molecular Aggregates Based on Zn^II and Sb^III/V Ions Displaying Efficient Antibacterial and Antioxidant Properties