Organic anion transporter 4 (OAT 4) modifies placental transfer of perfluorinated alkyl acids PFOS and PFOA in human placental ex vivo perfusion system

Kummu, Maria; Sieppi, Elina; Koponen, Jani; Laatio, Liisa; Vähäkangas, Kirsi; Kiviranta, Hannu; Rautio, Arja; Myllynen, Päivi

doi:10.1016/j.placenta.2015.07.119

Cited by 63 publications

(33 citation statements)

References 30 publications

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“…It has been shown that OAT4 is involved in the transport of 16-α-hydroxydehydroepiandrosterone sulfate, a metabolite of dehydroepiandrosterone sulfate, into the syncytiotrophoblast for estriol synthesis [32], as well as the transport of estrone-3-sulfate. OAT4 is responsible for the transport of exogenous compounds including olmesartan [33], perfluoroalkyl acids [59], and others [48]. Interestingly, OAT4 transporter function is enhanced in the presence of ions or ionic gradients, with an inwardly directed chloride gradient increasing substrate transport out of the syncytiotrophoblast, and transport function generally being reduced in the absence of sodium [32,33].…”

Section: Mechanisms Of Drug Transport Across the Placentamentioning

confidence: 99%

Placental control of drug delivery

Al-Enazy

Ali

Albekairi

et al. 2017

Advanced Drug Delivery Reviews

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The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products. When exogenous substances are present in the maternal bloodstream—whether from environmental contact, occupational exposure, medication, or drug abuse—the extent to which this exposure affects the fetus is determined by transport and biotransformation processes in the placental barrier. Advances in drug delivery strategies are expected to improve the treatment of maternal and fetal diseases encountered during pregnancy.

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Section: Mechanisms Of Drug Transport Across the Placentamentioning

confidence: 99%

Placental control of drug delivery

Al-Enazy

Ali

Albekairi

et al. 2017

Advanced Drug Delivery Reviews

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“…Within the placenta, the apical and basal membranes of syncytiotrophoblasts as well as fetal capillary endothelia have different transporters that can either uptake or efflux xenobiotics (Vahakangas and Myllynen, 2009). It has been suggested that the expression of a transport protein in the placenta, organic anion transporter 4 (OAT 4), decreases the transplacental transfer of PFOA and PFOS (Kummu et al, 2015). This indicates that the expression of various transporters in the placenta may play an important role in the transplacental transfer of PFASs.…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure and transplacental transfer of perfluoroalkyl substance isomers in participants from the upper and lower reaches of the Yangtze River

Liu

Zheng

et al. 2021

Environmental Pollution

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“…7,8 PFAAs could cross the placenta and are excreted in mother´s milk. [9][10][11] Modeling of infant exposure to some PFAAs suggests that in utero exposure and breastfeeding are important determinants of blood concentrations. 12,13 Food, drinking water, dust and air contribute to exposure when the child gets older.…”

Section: Introductionmentioning

confidence: 99%

Perfluoroalkyl Acids (PFAAs) in Serum from 2–4-Month-Old Infants: Influence of Maternal Serum Concentration, Gestational Age, Breast-Feeding, and Contaminated Drinking Water

Gyllenhammar

Benskin

Sandblom

et al. 2018

Environ. Sci. Technol.

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Little is known about factors influencing infant perfluorinated alkyl acid (PFAA) concentrations. Associations between serum PFAA concentrations in 2-4-month-old infants (n=101) and determinants were investigated by multiple linear regression and General Linear Model (GLM) analysis. In exclusively breastfed infants, maternal serum PFAA concentrations 3 weeks after delivery explained 13% (perfluoroundecanoic acid, PFUnDA) to 73% (perfluorohexane sulfonate, PFHxS) of infant PFAA concentration variation. Median infant/maternal ratios decreased with increasing PFAA carbon chain length from 2.8 for perfluoroheptanoic acid (PFHpA) and perfluorooctanoic acid (PFOA) to 0.53 for PFUnDA, and from 1.2 to 0.69 for PFHxS and perfluorooctane sulfonate (PFOS). Infant PFOA, perfluorononanoic acid (PFNA) and PFOS increased 0.7-1.2% per day of gestational age. Bottle-fed infants had 2 times lower mean concentrations of PFAAs, and a higher mean percentage of branched (%br) PFOS isomers, than exclusively breastfed infants. PFOA, PFNA and PFHxS increased 8-11% per week of exclusive breastfeeding. Infants living in an area receiving PFAA-contaminated drinking water had 3-fold higher mean perfluorobutane sulfonate (PFBS) and PFHxS concentrations, and higher mean %br PFHxS. Pre-and postnatal PFAA exposure significantly contribute to infant PFAA serum concentrations, depending on PFAA carbon-chain length. Moderately PFBS-and PFHxS-contaminated drinking water is an important indirect exposure source.

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Organic anion transporter 4 (OAT 4) modifies placental transfer of perfluorinated alkyl acids PFOS and PFOA in human placental ex vivo perfusion system

Cited by 63 publications

References 30 publications

Placental control of drug delivery

Placental control of drug delivery

Prenatal exposure and transplacental transfer of perfluoroalkyl substance isomers in participants from the upper and lower reaches of the Yangtze River

Perfluoroalkyl Acids (PFAAs) in Serum from 2–4-Month-Old Infants: Influence of Maternal Serum Concentration, Gestational Age, Breast-Feeding, and Contaminated Drinking Water

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