Organic affective disorder in a patient with congenital adrenal hyperplasia

Feldman, Steven R.; Krishnan, K. Ranga Rama; McPherson, Harry T.; Meglin, Diane E.

doi:10.1016/0006-3223(87)90209-5

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…An association between CAH and mood disorders was described several decades ago [ 33 ], and has been replicated in more recent research [ 17 , 34 ], indicating that glucocorticoids given as a pharmacological treatment, and not only as a substitute, may cause psychological and psychiatric symptoms like anxiety, insomnia, behavior disturbances, mood disorders, and psychotic disorders [ 35 ]. There is also evidence of androgens' influence on emotional reactivity, brain structure, and function, suggesting that young people with hyperandrogenism, such as in CAH, could be at risk of developing psychological symptoms or psychiatric disorders [ 36 ].…”

Section: Introductionmentioning

confidence: 98%

Psychological adjustment, quality of life, and self-perceptions of reproductive health in males with congenital adrenal hyperplasia: a systematic review

et al. 2018

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PurposeCongenital adrenal hyperplasia (CAH) has been shown to potentially affect psychological adjustment. However, most research has focused on females, and knowledge about psychological challenges in males remains sparse. The aim of this systematic review was therefore to assess these in males with CAH.MethodsWe systematically searched the OVID Medline, PsycINFO, CINAHL, and Web of Science databases, for articles published up to April 20, 2018, investigating psychological adjustment in males with CAH.ResultsEleven studies were included in the review. Three main health domains were identified: psychological and psychiatric health, quality of life (QoL), and self-perceptions of reproductive health. Some studies covered more than one health domain. Seven studies explored psychological adjustment and/or the presence of psychiatric symptoms or disorders. Results indicated that males with CAH had more problems related to internalizing behaviors (negative behaviors directed toward the self) and more negative emotionality compared to reference groups. Six studies examined QoL, five of them reporting reduced QoL compared to reference groups. Three studies explored the impact of fertility and sexual health issues on psychological health with varying results from impaired to normal sexual well-being.ConclusionsCAH seems to have an impact on males' psychological health. However, the number of identified studies was limited, included few participants, and revealed divergent findings, demonstrating the need for larger studies and highlighting a number of methodological challenges that should be addressed by future research.

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