Organic acids from Capparis spinosa fruit

Ren, Quanxia; Cui, Wen; Zhao, H. Y.; Wu, Zeng-Bao; Zhang, Hua

doi:10.1007/s10600-012-0404-0

Cited by 6 publications

(2 citation statements)

References 1 publication

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“…Compound 7 (peak 7 in Figure 2 B): ESI-MS ( m / z ): 139 [M + H] + , 137 [M − H] − , molecular formula C 7 H 6 O 3 , M = 138; 1 H-NMR (CD 3 OD- d 6 , 400 MHz) δ: 7.87 (2H, d, J = 8.8 Hz, H-3, 5), 6.81 (2H, d, J = 8.8 Hz, H-2, 6); 13 C-NMR (CD 3 OD- d 6 , 100 MHz) δ: 121.5 (C-1), 114.6 (C-2, 6), 131.6 (C-3, 5), 162.0 (C-4), 168.8 (C-7). Comparing the above data with the literature [ 26 , 27 ], compound 7 was identified as p -hydroxybenzoic acid.…”

Section: Methodssupporting

confidence: 61%

Chemical Constituents of the Ethyl Acetate Extract from Diaphragma juglandis Fructus and Their Inhibitory Activity on Nitric Oxide Production In Vitro

Wang

Dong

et al. 2017

Molecules

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Diaphragma juglandis fructus contains various bioactive constituents. Fourteen compounds were isolated from Diaphragma juglandis fructus by preparative high performance liquid chromatography (pre-HPLC) and high-speed counter-current chromatography (HSCCC). Their structures were identified by nuclear magnetic resonance (NMR) and electrospray ionization mass spectrometry (ESI-MS). Compounds (+)-dehydrovomifoliol (12), (6R,9R)-9-hydroxymegastigman-4-en-3-one (13) and (6R,9S)-9-hydroxymegastigman-4-en-3-one (14) are found from Juglans regia L. for the first time. Compounds dihydrophaseic acid (2), blumenol B (3) and (4S)-4-hydroxy-1-tetralone (11) are isolated from Diaphragma juglandis fructus for the first time. The anti-inflammatory effects of isolated compounds were evaluated by an in vitro model of lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Compounds gallic acid (1), ethyl gallate (9) and (+)-dehydrovomifoliol (12) exhibited inhibitory activity on the nitric oxide production of RAW 264.7 at a concentration of 25 μM. The result indicated that the combination HSCCC with pre-HPLC is an effective way for compound separation and purification. And Diaphragma juglandis fructus constituents have the potential for the treatment of inflammatory-related diseases.

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Section: Methodssupporting

confidence: 61%

Chemical Constituents of the Ethyl Acetate Extract from Diaphragma juglandis Fructus and Their Inhibitory Activity on Nitric Oxide Production In Vitro

Wang

Dong

et al. 2017

Molecules

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“…All compounds were identified by comparing observed data with published one for these compounds. These compounds were identified as isorhamnetin-3-O-β-D-galactopyranoside,[ 28 ] isorhamnetin-3-O-β-D-glucopyranoside,[ 29 ] isorhamnetin,[ 30 ] trans N-feruloyl tyramine,[ 31 ] isovanillic acid,[ 31 ] (ferulic acid,[ 32 ] and p -hydroxy benzoic acid,[ 33 ] respectivley.…”

Section: Resultsmentioning

confidence: 99%

New isorhamnetin derivatives from Salsola imbricata Forssk. leaves with distinct anti -inflammatory activity

El‐Kashak

Raey²

2016

Phcog Mag

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Background:Salsola imbricata Forssk. is a shrub widely growing in Egypt, used as a camel food, traditionally, used as anti-inflammatory agent. Literature survey showed no report about the anti-inflammatory activity of S. imbricata.Aim of the Study:This work was designed to study the phenolic constituents and to provide evidence for the traditional use of S. imbricata as an anti-inflammatory agent.Materials and Methods:The in vitro anti-inflammatory activity of the total aqueous methanol extract and some isolated compounds were investigated in RAW 264.7 macrophage cells using nitric oxide assay. All chemical structures were identified on the basis of electrospray ionization-mass spectrometry, one- and two-dimension nuclear magnetic resonance.Results:Nine phenolic compounds, among them two new natural products; isorhamnetin-3-O-β-D-glucuronyl (1’’’→4’’) glucuronide (1) and its dimethyl ester; isorhamnetin-3-O-β-D-di glucuronate dimethyl ester (2), two isorhamnetin glycosides: Isorhamnetin-3-O-β-D-galactopyranoside (3), isorhamnetin-3-O-β-D-glucopyranoside (4), and isorhamnetin (5). In addition, an alkaloidal phenolic; trans N-feruloyl tyramine (6), three phenolic acids: Isovanillic acid (7), ferulic acid (8), and p-hydroxy benzoic acid (9) were isolated from salsola imbricata leaves. All compounds were isolated and identified for the first time from this plant except compound (6). The extract and the tested compounds showed distintict anti-inflammatory activities with no toxicity on RAW 264.7 macrophage cells.Conclusion:The extract and the tested compounds showed distintict anti-inflammatory activities with no toxicity on RAW 264.7 macrophage cells.SUMMARY Investigation of the chemical constituents of the leaves of Salsola imbricata led to isolation of two new isorhamnetin derivatives: isorhamnetin.3-O-β-D.glucuronyl (1’“→”) glucuronide (1) and its dimethyl ester (2), together with seven known phenolic compounds. The extract and the tested compounds showed distintict anti-inflammatory activities with no toxicity on RAW 264.7 macrophage cells. Abbreviations used: PC: Paper chromatography, MPLC : Medium Pressure Liquid Chromatography, HMBC: Heteronuclear multiple bond correlation, HMQC: Heteronuclear single quantum correlation, NMR: Nuclear magnetic resonance

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Components of Hypoxylon sp.

Cheng

Hsieh

et al. 2020

Chem Nat Compd

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Organic acids from Capparis spinosa fruit

Cited by 6 publications

References 1 publication

Chemical Constituents of the Ethyl Acetate Extract from Diaphragma juglandis Fructus and Their Inhibitory Activity on Nitric Oxide Production In Vitro

Chemical Constituents of the Ethyl Acetate Extract from Diaphragma juglandis Fructus and Their Inhibitory Activity on Nitric Oxide Production In Vitro

New isorhamnetin derivatives from Salsola imbricata Forssk. leaves with distinct anti -inflammatory activity

Components of Hypoxylon sp.

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