Organ Specificity of Induction of Activating and Inactivating Enzymes by Cigarette Smoke and Cigarette Smoke Condensate

Gielen, Jean-Louis; Goujon, F.M.; Sele, Jocelyne; Cantfort, J. Van

doi:10.1007/978-3-642-67265-1_20

Cited by 14 publications

(1 citation statement)

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“…Therefore, the relationship between HYL1 enzyme activity and exon 3 and exon 4 polymorphisms is still uncertain. HYL1 enzyme activity is induced by cigarette smoke (Gielen et al, 1979). A significant increase in HYL1 activities of human lung tissues was found among smokers, as compared with non-smokers (Bartsch et al, 1992).…”

Section: Discussionmentioning

confidence: 93%

Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma

Lin¹,

Sl²,

Hj³

et al. 2000

Br J Cancer

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Lung cancer is the leading cause of death among cancers in Taiwan. Although the etiology of lung cancer has yet to be defined, genetic variability in activities of metabolic enzymes has been correlated with lung cancer. In the present study, the possibility of association of CYP1A1 and microsomal epoxide hydrolase ( HYL1 ) genetic polymorphisms with lung cancer was examined among 132 lung cancer patients and 259 controls in Taiwan. No significant association was observed for either CYP1A1 or HYL1 polymorphism alone and the overall incidence of lung cancer after adjusting for age, gender and smoking status. When cases were stratified according to histological type, there was significant association between CYP1A1*2A homozygote and squamous cell carcinoma (SCC) (odds ratio (OR) 2.86; 95% confidence interval (CI) 1.33–6.12). Similarly, the proportion of HYL1 genotypes corresponding to high or normal enzyme activities was higher in SCC than in controls (OR 1.96; 95% CI 1.04–3.70). A combination of susceptible CYP1A1 and HYL1 genotypes was found to be highly associated with lung cancer, especially with SCC (OR 6.76; 95% CI 2.29–19.10). Our results suggest that the combination of CYP1A1 and HYL1 polymorphisms is an important risk factor for lung SCC. © 2000 Cancer Research Campaign

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Section: Discussionmentioning

confidence: 93%