Organ-Specificity of Breast Cancer Metastasis

Ibragimova, Marina K.; Tsyganov, Matvey M.; Kravtsova, Ekaterina A.; Tsydenova, Irina A.; Litviakov, Nikolai V.

doi:10.3390/ijms242115625

Cited by 9 publications

(4 citation statements)

References 105 publications

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“…29 In addition, the expression of specific genes could promote organ-specific metastasis; breast cancer lung metastasis was related to SIRT7, VCAM-1, and Cx43. 30 Though the mechanics of lung could be a contributing factor since it is the end organ with extensive capillary blood supply, 2 successful colonization in the lung can be explained by lung-specific microenvironmental factors. Extrathoracic cancers secreting factors and extracellular vesicles adjust the lung microenvironment to transit into pre-metastatic niches.…”

Section: Discussionmentioning

confidence: 99%

The role of pulmonary metastasectomy (PM) for non-primary lung cancer: Umbrella review of meta-analyses

Woo,

Park,

Ahadi

et al. 2024

Preprint

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Introduction: Due to heterogeneous characteristics of primary cancers, the efficacy of pulmonary metastasectomy(PM) in non-primary lung cancers has not been investigated other than colorectal cancers. This study aims to investigate the clinical outcomes of PM for non-primary lung cancer. Methods: A systematic search for meta-analyses on PM for non-primary lung cancers was conducted, encompassing publications up to January 3, 2024. The analysis included seven primary cancer types: renal cell, breast, adrenocortical, head and neck cancers, melanoma, germ cell tumors, and sarcoma. Primary outcomes, overall survival, and recurrence rates post-PM were assessed using random-effect models to account for study heterogeneity. Results: This study included 16 systematic-review articles and 101 individual studies, involving 10,277 patients who underwent PM for non-primary lung cancer. Patients had a mean age of 48.0 years, with 68.4% being male. About half of the patients(47.1% [95%CI 40.8-53.5] presented with multiple metastatic lesions, and complete R0 resection achieved in 87.2% [95%CI 83.0-90.8]. The pooled 5-year overall survival (OS) rate post-PM was 41.2% [95%CI, 37.1-45.4%]. Patients with germ cell tumors demonstrated significantly higher survival rate than other cancers(p<0.05), while patients with melanoma exhibited the poorest outcome(p<0.05). During follow-up, 57.6%[95%CI 46.4-68.1] had recurrence; 48% of them had intrathoracic-only recurrence and 52% had extra-thoracic recurrence. Conclusion: This study underscores the survival benefits associated with PM. Overall survival rates following PM do not significantly differ based on primary cancer types, except for germ cell tumors and melanoma. These findings highlight the importance of recognizing and incorporating PM into clinical practice when appropriate.

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Section: Discussionmentioning

confidence: 99%

The role of pulmonary metastasectomy (PM) for non-primary lung cancer: Umbrella review of meta-analyses

Woo,

Park,

Ahadi

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…Breast cancer is the most prevalent cancer in women globally, with an increasing mortality rate that appears to be unabated [ 50 ]. Metastasis is correlated with >90% of breast cancer-associated deaths [ 3 , 51 , 52 ]. Metastasis is a complex process involving a series of events that result in the formation of new tumors at a secondary site [ 3 , 4 ] through invasion and tumor dissemination.…”

Section: Discussionmentioning

confidence: 99%

“…Invasion involves the remodeling and reconstruction of the ECM using proteolytic enzymes such as matrix metalloproteinases (MMPs) to create microchannels for cells to penetrate the stroma to reach vascular, lymphatic, or trans-coelomic routes [ 3 , 4 , 52 ]. Thus, successful invasion is central to metastasis.…”

Section: Discussionmentioning

confidence: 99%

Chlorogenic Acid and Cinnamaldehyde in Combination Inhibit Metastatic Traits and Induce Apoptosis via Akt Downregulation in Breast Cancer Cells

Olayiwola,

Gollahon

2024

IJMS

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Most reported breast cancer-associated deaths are directly correlated with metastatic disease. Additionally, the primary goal of treating metastatic breast cancer is to prolong life. Thus, there remains the need for more effective and safer strategies to treat metastatic breast cancer. Recently, more attention has been given to natural products (or phytochemicals) as potential anticancer treatments. This study aimed to investigate the synergistic effects of the combination of the phytochemicals chlorogenic acid and cinnamaldehyde (CGA and CA) toward inhibiting metastasis. The hypothesis was that CGA and CA in combination decrease the metastatic potential of breast cancer cells by inhibiting their invasive and migratory abilities as well as the induction of apoptosis via the downregulation of the Akt, disrupting its signal transduction pathway. To test this, wound-healing and Transwell™ Matrigel™ assays were conducted to assess changes in the migration and invasion properties of the cells; apoptosis was analyzed by fluorescence microscopy for Annexin V/propidium iodide; and immunoblotting and FACSort were performed on markers for the epithelial-to-mesenchymal transition status. The results show that CGA and CA significantly downregulated Akt activation by inhibiting phosphorylation. Consequently, increased caspase 3 and decreased Bcl2-α levels were observed, and apoptosis was confirmed. The inhibition of metastatic behavior was demonstrated by the attenuation of N-cadherin, fibronectin, vimentin, and MMP-9 expressions with concomitant increased expressions of E-cadherin and EpCAM. In summary, the present study demonstrated that CGA and CA in combination downregulated Akt activation, inhibited the metastatic potential, and induced apoptosis in different breast cancer cell lines.

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“… 1 Metastasis to vital organs remains the leading cause of death in patients with BC. 2 The evolution of solid tumor metastasis is a complex process involving cell invasion from the primary tumor, circulatory system infiltration and extravasation, and distant growth. 3 As the tumor progresses, a locally supportive and receptive microenvironment known as the pre-metastatic niche prepares the tumor cells to colonize before these cells reach distant organs, thus facilitating tumor settlement and metastasis.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles for the Treatment of Bone Metastasis in Breast Cancer: Recent Advances and Challenges

Yu,

Zhu

2024

IJN

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Although the frequency of bone metastases from breast cancer has increased, effective treatment is lacking, prompting the development of nanomedicine, which involves the use of nanotechnology for disease diagnosis and treatment. Nanocarrier drug delivery systems offer several advantages over traditional drug delivery methods, such as higher reliability and biological activity, improved penetration and retention, and precise targeting and delivery. Various nanoparticles that can selectively target tumor cells without causing harm to healthy cells or organs have been synthesized. Recent advances in nanotechnology have enabled the diagnosis and prevention of metastatic diseases as well as the ability to deliver complex molecular “cargo” particles to metastatic regions. Nanoparticles can modulate systemic biodistribution and enable the targeted accumulation of therapeutic agents. Several delivery strategies are used to treat bone metastases, including untargeted delivery, bone-targeted delivery, and cancer cell-targeted delivery. Combining targeted agents with nanoparticles enhances the selective delivery of payloads to breast cancer bone metastatic lesions, providing multiple delivery advantages for treatment. In this review, we describe recent advances in nanoparticle development for treating breast cancer bone metastases.

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Organ-Specificity of Breast Cancer Metastasis

Cited by 9 publications

References 105 publications

The role of pulmonary metastasectomy (PM) for non-primary lung cancer: Umbrella review of meta-analyses

The role of pulmonary metastasectomy (PM) for non-primary lung cancer: Umbrella review of meta-analyses

Chlorogenic Acid and Cinnamaldehyde in Combination Inhibit Metastatic Traits and Induce Apoptosis via Akt Downregulation in Breast Cancer Cells

Nanoparticles for the Treatment of Bone Metastasis in Breast Cancer: Recent Advances and Challenges

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