Organ specificity and commonality of epigenetic aging in low- and high-running capacity rats
Takuji Kawamura,
Csaba Kerepesi,
Ferenc Torma
et al.
Abstract:Background: Epigenetic drift, which are gradual age-related changes in DNA methylation patterns, plays a significant role in aging and age-related diseases. However, the relationship between exercise, epigenetics, and aging and the molecular mechanisms underlying their interactions are poorly understood. The aim of this study was to investigate the relationship between cardiorespiratory fitness (CRF), epigenetic aging, and promoter methylation of individual genes across multiple organs in selectively bred low-… Show more
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