Organ-specific production of alkaloids from bulbs and seeds of Crinum stuhlmannii subsp. delagoense (Amaryllidaceae)

Moodley, Nivan; Crouch, Neil R.; Mas‐Claret, Eduard; Houghton, Peter J.; Mulholland, Dulcie A.

doi:10.1016/j.sajb.2020.08.014

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…Seeds of the Haemantheae are large and are assumed to be toxic on the basis that other plant parts are highly toxic and the seeds are never eaten and are extremely bitter‐tasting to humans (Kiepiel & Johnson, 2019; Nair & van Staden, 2022). Studies of related amaryllids have shown that their seeds are defended by alkaloids (Moodley et al, 2022). Seed toxicity is the most likely reason why rodents appeared to discard the seeds without consuming them.…”

Section: Discussionmentioning

confidence: 99%

Directed vertebrate‐mediated seed dispersal of a fleshy‐fruited amaryllid in a heterogenous habitat

Butler

Johnson

2023

Biotropica

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Seed dispersal is a key process, contributing to the spread and abundance of plant species and, ultimately, the biotic diversity in communities (Cain et al., 2000;Cousens et al., 2008). The seed dispersers of plants are important for the distances of seed dispersal and the microhabitat in which seeds land, both of which influence the chances of successful recruitment (Howe & Miriti, 2004). The effectiveness of a seed disperser depends on the quality of the seeds dispersed as well as the quality of the habitat provided for each dispersed seed (Schupp, 1993). Seed dispersal kernels (the probabilities of their dispersal distances) affect abundance, diversity, and distribution, which in turn are affected by habitat structure (Levine & Murrel, 2003).Dispersal kernels need to correspond to the spatial structure of the habitat patches required for seedlings to survive and in some cases, this may actually favor short-distance dispersal (Mathius et al., 2001).Plants with seeds dispersed by frugivorous birds and monkeys are usually characterized by fleshy, brightly colored fruits

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Section: Discussionmentioning

confidence: 99%

Directed vertebrate‐mediated seed dispersal of a fleshy‐fruited amaryllid in a heterogenous habitat

Butler

Johnson

2023

Biotropica

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“…Then the authors add 20 ll of DTNB (10 mM) in phosphate buffer (pH 7) and 20 ll of ATCI (0.03-0.05 mM in water) incubating the mixture at 25 °C for 6 min before spectrophotometric measurement at 412 nm. Moodley et al (2021) assayed the AChE inhibitory activity of alkaloids from Crinum stuhlmannii applying a method described by Ren et al (2004). The authors use 40 lL of 0.86 U/ml AChE solution (pH 8) and 20 ll of sample solutions in 2.0 ml phosphate buffer starting the reaction after 20 min with 20 ll of DTNB (0.05 mM) in phosphate buffer (pH 7) and 20 ll of ATCI (0.06 mM in buffer, pH7).…”

Section: Spectrophotometric Methodsmentioning

confidence: 99%

The Amaryllidaceae alkaloids: an untapped source of acetylcholinesterase inhibitors

et al. 2021

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The AChE inhibitory activity of alkaloid extracts and compounds has been in the focus of research on the plants of Amaryllidoideae subfamily since the approval of galanthamine in 2001 by FDA for treatment of mild to moderate Alzheimer's disease. A small fraction of the huge biodiversity of the plants producing Amaryllidaceae alkaloids has been studied as a source of AChE inhibitors. Less than 20% of the known Amaryllidaceae alkaloids have been tested in vitro for their ability to inhibit AChE. Galanthamine, lycorine and haemanthamine are scaffolds for semi-synthesis of potent AChE inhibitors. In the last years, galanthamine has been studied in silico for drug optimization and synthesis of potent dual-binding AChE inhibitors. In silico studies of other Amaryllidaceae alkaloids have also provoked the interest of researchers in the last years. The aim of this article is to provide a comprehensive review on studies of the AChE inhibitory activity of extracts and compounds from the plants of Amaryllidoideae subfamily covering the literature from the last two decades.

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“…Origem da substância das substâncias foi realizada por meio da Cromatografia em coluna de gel de sílica 10,11,12,13,15,17,18,19 , Cromatografia de fase reversa 20 e Cromatografia líquida Acquity Ultra Performance 20 .…”

Section: Substâncias Estudadasunclassified

Atividade de alcaloides inibidores da acetilcolinesterase no tratamento da doença de Alzheimer: uma revisão sistemática

Mambro

Souza²,

Silva³

2022

J Health Biol Sci.

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Objetivo: descrever a atividade de inibição da enzima acetilcolinesterase (AChE), por meio de ativos extraídos de alcaloides naturais. Metodologia: este estudo se configura como uma revisão sistemática da literatura, no período de janeiro de 2015 a setembro de 2021, nas bases de dados PUBMED, LILACS e SCIENCE DIRECT, com os descritores Acetylcholinesterase; Alzheimer; Alkaloids. As informações obtidas foram tabuladas para avaliação dos alcaloides inibidores da acetilcolinesterase. Resultados: de 563 artigos encontrados, 17 foram utilizados. Dois deles relataram a atividade de alcaloides inibidores da AChE por meio de ensaios clínicos, enquanto os demais a realizaram por testes in vitro. De 160 substâncias estudadas, 48 apresentaram atividade anticolinesterásica, as quais foram avaliadas de acordo com a sua concentração inibitória média (IC50). Discussão: a eficiência dos alcaloides como inibidores da AChE, provavelmente está relacionada com sua carga positiva no pH do organismo e sua boa biodisponibilidade, tendo como consequência uma atividade duradoura in vivo, em comparação com os medicamentos sintéticos. Conclusão: no presente estudo, foi possível observar uma grande diversidade de substâncias alcalóidicas antiAChE. Contudo, torna-se necessária a realização de mais ensaios in vivo e in vitro para a constatação efetiva da atividade dessas moléculas.

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Organ-specific production of alkaloids from bulbs and seeds of Crinum stuhlmannii subsp. delagoense (Amaryllidaceae)

Cited by 7 publications

References 23 publications

Directed vertebrate‐mediated seed dispersal of a fleshy‐fruited amaryllid in a heterogenous habitat

Directed vertebrate‐mediated seed dispersal of a fleshy‐fruited amaryllid in a heterogenous habitat

The Amaryllidaceae alkaloids: an untapped source of acetylcholinesterase inhibitors

Atividade de alcaloides inibidores da acetilcolinesterase no tratamento da doença de Alzheimer: uma revisão sistemática

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