Organ-specific metastasis of breast cancer: molecular and cellular mechanisms underlying lung metastasis

Yousefi, Meysam; Nosrati, Rahim; Salmaninejad, Arash; Dehghani, Sadegh; Shahryari, Ali; Saberi, Alihossein

doi:10.1007/s13402-018-0376-6

Cited by 105 publications

(79 citation statements)

References 175 publications

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“…E0771/shBMAL1-derived tumors from LFD-fed mice had the least proliferative potential. We next examined whole lungs from obese and lean tumor-harboring mice as lungs are a common site of metastasis from E0771-derived mammary tumors (Yousefi et al, 2018). Likewise, the obese tumor-bearing mice harbored more lung tumor nodules than the lean group ( Figure 3D).…”

Section: Bmal1 Suppresses Hfd-induced Tumor Growth In Vivomentioning

confidence: 99%

A Non-canonical Function of BMAL1 Metabolically Limits Obesity-Promoted Triple-Negative Breast Cancer

Ramos

Ouyang

et al. 2020

iScience

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Section: Bmal1 Suppresses Hfd-induced Tumor Growth In Vivomentioning

confidence: 99%

A Non-canonical Function of BMAL1 Metabolically Limits Obesity-Promoted Triple-Negative Breast Cancer

Ramos

Ouyang

et al. 2020

iScience

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“…The metastatic cells then regulate the microenvironment by releasing cytokines and interacting with other cells (8). Recently, it was reported that organ-specific endothelial cells regulate organ-specific metastasis (9). Dysregulated endothelial cell behavior is vital in establishing the tumor microenvironment by producing…”

Section: Introductionmentioning

confidence: 99%

ADAM17-regulated CX3CL1 expression produced by bone marrow endothelial cells promotes spinal metastasis from hepatocellular carcinoma

Sun

Wang

et al. 2020

Int J Oncol

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Spinal metastasis occurs in 50-75% of bone metastases caused by hepatocellular carcinoma (HCC), and HCC-derived spinal metastasis can lead to a less favorable prognosis. Recently, several studies have demonstrated that C-X3-C motif chemokine ligand 1 (CX3CL1) is closely associated with cancer metastasis, and its secretion is modulated by a disintegrin and metalloproteinase 17 (ADAM17). Bone marrow endothelial cells (BMECs) are an essential component of bone marrow. However, little is known about the roles in and effects of BMECs on HCC spinal metastasis. The present study demonstrated that CX3CL1 and C-X-C motif chemokine receptor 3 (CXCR3) expression was upregulated in HCC spinal metastases, and that CX3CL1 promoted the migration and invasion of HCC cells to the spine. Western blot analysis revealed that the Src/protein tyrosine kinase 2 (PTK2) axis participated in CX3CL1-induced HCC cell invasion and migration. CX3CL1 also increased the expression of M2 macrophage markers in THP-1 monocytes. BMECs promoted the migration and invasion of Hep3B and MHCC97H cells by secreting soluble CX3CL1, whereas the neutralization of CX3CL1 inhibited this enhancement. CX3CL1 enhanced the activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)/AKT serine/threonine kinase 1 (AKT1) and Ras homolog family member A (RHOA)/Rho associated coiled-coil containing protein kinase 2 (ROCK2) signaling pathways through the Src/PTK2 signaling pathway. Furthermore, ADAM17 was activated by mitogen-activated protein kinase (MAPK) z14 in BMECs and significantly promoted the secretion of CX3CL1. HCC cells enhanced the recruitment and proliferation of BMECs. The overexpression of CX3CR1 facilitated the spinal metastasis of HCC in a mouse model in vivo. In addition, in vivo experiments revealed that BMECs promoted the growth of HCC in the spine. The present study demonstrated that CX3CL1 participates in HCC spinal metastasis, and that BMECs play an important role in the regulation of CX3CL1 in the spinal metastatic environment.

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“…BC invasion and metastasis are the main causes of BC-related deaths. Bone, lung, brain, and liver are the primary target sites of BC metastasis [ 2 ]. BC metastasis is the spread of cancer cells to tissues and organs beyond where the tumor originated and the formation of new tumors which may eventually result in the death of most BC patients [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The regulatory roles of lncRNAs in the process of breast cancer invasion and metastasis

Zhou

Yang

et al. 2018

Bioscience Reports

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Breast cancer (BC) is the most common cancer and principal cause of death among females worldwide. Invasion and metastasis are major causes which influence the survival and prognosis of BC. Therefore, to understand the molecule mechanism underlying invasion and metastasis is paramount for developing strategies to improve survival and prognosis in BC patients. Recent studies have reported that long non-coding RNAs (lncRNAs) play critical roles in the regulation of BC invasion and metastasis through a variety of molecule mechanisms that endow cells with an aggressive phenotype. In this article, we focused on the function of lncRNAs on BC invasion and metastasis through participating in epithelial-to-mesenchymal transition, strengthening cancer stem cells generation, serving as competing endogenous lncRNAs, influencing multiple signaling pathways as well as regulating expressions of invasion–metastasis related factors, including cells adhesion molecules, extracellular matrix, and matrix metallo-proteinases. The published work described has provided a better understanding of the mechanisms underpinning the contribution of lncRNAs to BC invasion and metastasis, which may lay the foundation for the development of new strategies to prevent BC invasion and metastasis.

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Organ-specific metastasis of breast cancer: molecular and cellular mechanisms underlying lung metastasis

Abstract: Detailed understanding of the mechanisms underlying BCLM will shed a new light on the identification of novel molecular targets to impede daunting pulmonary metastases in patients with breast cancer.

Cited by 105 publications

References 175 publications

A Non-canonical Function of BMAL1 Metabolically Limits Obesity-Promoted Triple-Negative Breast Cancer

A Non-canonical Function of BMAL1 Metabolically Limits Obesity-Promoted Triple-Negative Breast Cancer

ADAM17-regulated CX3CL1 expression produced by bone marrow endothelial cells promotes spinal metastasis from hepatocellular carcinoma

The regulatory roles of lncRNAs in the process of breast cancer invasion and metastasis

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