Organ-specific autoantibodies in non-organ-specific autoimmune diseases with special reference to rheumatoid arthritis

Youinou, Pierre; Mangold, W.; Jouquan, Jean; Swirsky, H; Goff, P. Le; Scherbaum, W. A.

doi:10.1007/bf00270464

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…In this respect, it is interesting that the histopathologic picture of pSS exocrine glands and autoimmune thyroid glands show great similarities, such as infiltration by activated T lymphocytes (3, 4), epithelial expression of HLA class II molecules (5, 6), and clonal B cell expansion (7). Furthermore, antithyroid antibodies have been detected in a proportion of patients with nonorgan‐specific autoimmune conditions, including pSS, systemic lupus erythematosus (SLE), or rheumatoid arthritis (RA) (8, 9). The question thus arises as to whether patients with pSS are at risk of developing autoimmune thyroid disease (AT).…”

Section: Introductionmentioning

confidence: 99%

Thyroid dysfunction in primary Sjögren's syndrome: A long‐term followup study

d’Arbonneau¹,

Ansart²,

Berre³

et al. 2003

Arthritis & Rheumatism

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Section: Introductionmentioning

confidence: 99%

Thyroid dysfunction in primary Sjögren's syndrome: A long‐term followup study

d’Arbonneau¹,

Ansart²,

Berre³

et al. 2003

Arthritis & Rheumatism

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“…U È ber die Koinzidenz von cP und Hashimoto Thyreoiditis existieren nur wenige Berichte mit teilweise widerspru Èchlichen Ergebnissen (6, 7, 11 12, 13, 15, 19). Bereits Anfang der 60er Jahre wurde Andere Untersucher wiederum finden keine geha Èufte Koinzidenz zwischen den beiden Krankheiten (11,12,13,19).…”

Section: Diskussionunclassified

“…Wa Èhrend einige Autoren eine Assoziation zwischen Autoimmunthyreopathien und cP aufzeigen (4, 6, 7), kann diese von anderen Gruppen nicht besta Ètigt werden (12,13,19 Die Signifikanzpru Èfung ergab, dass die Immunthyreoiditis bei Patienten mit cP signifikant ha Èufiger auftritt als in der Kontrollgruppe mit Osteoarthrosen (Abb. 1; 9,1 % vs. 3,7 %, Chi-Quadrat: p = 0,0016, ¹exakter Testª von R. A. Fisher auf Unabha Èngigkeit: p = 0,0019).…”

Section: Introductionunclassified

Gehaftes Auftreten der Immunthyreoiditis bei Patienten mit chronischer Polyarthritis

Pongratz¹,

Buchinger²,

Semlitsch³

et al. 2000

Acta Med Austriaca

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The frequent occurrence of both rheumatoid arthritis and autoimmune thyroiditis was already investigated with in part many conflicting results. We investigated a number of 792 patients (383 of them suffering from rheumatoid arthritis and 409 with osteoarthritis). In all patients antithyroid peroxidase and antithyroglobulin antibodies were determined. Patients with rheumatoid arthritis showed a significantly higher occurrence of circulating thyroid antibodies than those with osteoarthritis (9.1% versus 3.7%, p = 0.0016). We conclude that there exists a cumulate coincidence of both diseases. Patients suffering from rheumatoid arthritis should undergo a thyroid examination especially for the presence of autoimmune thyroiditis.

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Histologic and electron microscopic characterization of the antiperinuclear factor antigen

Vivino

Maul

1990

Arthritis & Rheumatism

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The presence of the antiperinuclear factor, an autoantibody that recognizes cytoplasmic antigens, was detected in sera from patients with rheumatoid arthritis (59%), seronegative rheumatoid arthritis (36%), systemic lupus erythematosus (46%), systemic sclerosis (a%), and in nonautoimmune controls (10%). The antigenic perinuclear granules were found in the stratum intermedium layer of the buccal mucosa. Granules exhibited histologic features of nucleoproteins, stained for ribonucleoprotein, and showed the ultrastructural characteristics of aggregated rough endoplasmic reticulum. The antiperinuclear factor may recognize a common autoantigen in connective tissue disease.Rheumatoid arthritis (RA) patients, similar to those with related disorders, can form a variety of autoantibodies against nuclear, cytoplasmic, and tissue-specific antigens ( 1,2). Antiperinuclear factor (APF). first described in the mid-1960s by Nienhuis and Mandema (3). is an autoantibody that recognizes cytoplasmic granules in human buccal mucosal cells. geneous-appearing granules, 0.54.0 pm in diameter, located in the cytoplasm around the nucleus. Investigators have found APF in the sera of 50436% of RA patients (4-15), 31-3% of patients with Sjogren's syndrome (5,9,13), as many as 10% of healthy controls, and rarely in other rheumatic disease patients (3-7). A recent study suggested that APF determination in rheumatic disease patients by indirect immunofluorescence had a sensitivity and specificity for RA of 86% and 96%. respectively (7). The presence of APF correlates most closely with the presence of rheumatoid factor and rheumatoid nodules, but the antibody has also been detected in 37-76% of patients with seronegative RA (5-8).The APF antibody binds to cytoplasmic granules in human buccal mucosal cells, which have presumptively been termed "keratohyaline granules" (4.16) based on their rough histologic resemblance to the keratohyaline bodies in the stratum granulosum of human epidermis. The biologic and biochemical nature of the APF-reactive granules is unknown. Attempts to characterize the antigen have thus far been hampered by a lack of availability of suitable human donors (5-7) or alternate animal tissue substrates for the assay (16). However, independent studies in oral medicine (17-20) have documented the presence of at least 3 types of cytoplasmic granules in human oral keratinocytes, including "membrane-coated" granules, "epidermaltype" keratohyaline granules, and "buccal-type'' keratohyaline granules; these findings have not been related to the APF antigen.In this report, we extend our preliminary observations regarding the prevalence of APF in various rheumatic diseases (21) and the staining characteristics of the perinuclear antigen-containing granules (22). The diagnostic specificity of the APF assay (by indi-

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Organ-specific autoantibodies in non-organ-specific autoimmune diseases with special reference to rheumatoid arthritis

Cited by 8 publications

References 26 publications

Thyroid dysfunction in primary Sjögren's syndrome: A long‐term followup study

Thyroid dysfunction in primary Sjögren's syndrome: A long‐term followup study

Gehaftes Auftreten der Immunthyreoiditis bei Patienten mit chronischer Polyarthritis

Histologic and electron microscopic characterization of the antiperinuclear factor antigen

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