Organ-specific Antibodies in Patients with Lichen Sclerosus

Goolamali, S.K.; Barnes, Erin; Irvine, W. J.; Shuster, Sam

doi:10.1136/bmj.4.5936.78

Cited by 102 publications

(42 citation statements)

References 9 publications

(4 reference statements)

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“…Der LS ist als unheilbare und progrediente, zu Remissionen neigende Dermatose klassifiziert. Die häufige Assoziation mit Autoimmunerkrankungen, insbesondere der Hashimoto Thyreoiditis und Autoimmungastritis, spricht jedoch für eine Autoimmungenese [14,15,21,22]. Ebenso als Ursachen diskutiert werden genetische Faktoren ( [31]; eigene Beobachtungen),HLA-Klasse-II-AntigenAssoziationen [3,22], Borrellieninfektionen [1] und hormonelle Faktoren wie erniedrigte endogene Östrogenproduktion und gestörter Testosteronmetabolismus der Haut [1].…”

Section: Klassifikation Des Lsunclassified

Lichen sclerosus vulvae

et al. 2004

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Vulvar lichen sclerosus (LS) is a chronic progressive skin disease of unclear etiology. It is often overlooked in early stages, but progresses to destructive atrophy and is associated with an increased risk of vulvar squamous cell carcinoma. The classical symptoms are pruritus and pain, but they are often not distinctive, so that unclear vulvar problems often lead to a biopsy. The histological picture of early LS is quite different from that of late LS with an atrophic epidermis, markedly sclerotic dermis and stiff dilated vessels. The epidermis in early LS is usually normal with only minor irregularities in the rete pattern. The basement membrane is normal or focally widened, while the edematous dermis has only scattered ectatic vessels. The often dense lichenoid and intraepidermal infiltrate explains the spongiosis and vacuolization of the basal layer keratinocytes. Very early cases may only have a sparse lymphocytic infiltrate and hyper-/parakeratosis of the follicular ostia. Early topical therapy can dampen the progression to atrophic, irreversible LS.

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Section: Klassifikation Des Lsunclassified

Lichen sclerosus vulvae

et al. 2004

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“…An increased incidence of organ-specific antibodies (absent in this case) has been noted in this condition,7 8 …”

Section: Featuresmentioning

confidence: 99%

Ulcerative vulvitis in Reiter's syndrome. A case report.

Daunt¹,

Kotowski²,

O’Reilly³

et al. 1982

Sexually Transmitted Infections

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SUMMARY In a case of acute Reiter's syndrome with severe vulvitis the diagnosis was based on the presence of a vaginal discharge and dysuria, arthritis, conjunctivitis, buccal ulceration, keratodermia blenorrhagica, and HLA B27 tissue-typing antigen. The vulval lesions were similar in appearance to those of circinate vulvitis. The acute histological change were confined to shallow ulceration with an inflammatory infiltration of the subjacent dermis. Coincidential lichen sclerosus et atrophicus was present, which could have been masked by the acute lesions.

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“…No existen factores de riesgos hasta ahora identificados, y no se relaciona con el uso de anticonceptivos o terapias de reemplazo hormonal (1,2,4). Si bien su origen es hasta ahora desconocido, existen numerosos estudios que intentan definir una etiología, dentro de las que destacan su probable origen autoinmune, genético, viral e infeccioso (6,7,8,9).…”

Section: Introductionunclassified

Valor De La Biopsia Vulvar en El Diagnóstico De Liquen Escleroso en Pacientes Con Alteraciones Vulvares Crónicas

Chahuán

2004

Rev. chil. obstet. ginecol.

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RESUMENSe presenta un estudio prospectivo donde se realizó biopsia vulvar a pacientes con síntomas y/o alteraciones vulvares crónicas de más de un año de evolución. Se destaca la importancia de la biopsia vulvar como un procedimiento sencillo, barato y exento de complicaciones, vital en la confirmación diagnóstica de liquen escleroso. PALABRAS CLAVES: Liquen escleroso, vulva, biopsia SUMMARYA prospective study is presented. A vulvar biopsy was carried out in patients with symptoms and/or chronic vulvar alterations of more than one year of evolution. We stands out the importance of the vulvar biopsy like a simple, cheap procedure and exempt of complications, vital in the diagnostic confirmation of lichen sclerosus.

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Organ-specific Antibodies in Patients with Lichen Sclerosus

Cited by 102 publications

References 9 publications

Lichen sclerosus vulvae

Lichen sclerosus vulvae

Ulcerative vulvitis in Reiter's syndrome. A case report.

Valor De La Biopsia Vulvar en El Diagnóstico De Liquen Escleroso en Pacientes Con Alteraciones Vulvares Crónicas

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