Organ-specific accumulation of cadmium and zinc in Gammarus fossarum exposed to environmentally relevant metal concentrations

Gestin, Ophélia; Lopes, Christelle; Delorme, Nicolas; Garnero, Laura; Geffard, Olivier; Lacoue-Labarthe, Thomas

doi:10.1016/j.envpol.2022.119625

Cited by 13 publications

(9 citation statements)

References 50 publications

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“…Therefore, some divalent metal ions and Fe 3+ were selected in order to examine their effect on the DNA-graphene interaction. To verify the validity, the influence of high-concentration metal ions (100 times the environmentally relevant condition) 37,38 on the experiment was investigated. Different metal ions themselves had a certain effect on the fluorescence of FAM-labeled DNA.…”

Section: Environmental Science: Nano Papermentioning

confidence: 99%

DNA damage caused by light-driven graphene oxide: a new mechanism

Wang

Zeng

Yang

et al. 2023

Environ. Sci.: Nano

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Section: Environmental Science: Nano Papermentioning

confidence: 99%

DNA damage caused by light-driven graphene oxide: a new mechanism

Wang

Zeng

Yang

et al. 2023

Environ. Sci.: Nano

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“…Two case studies concern the species Gammarus fossarum exposed to cadmium (Cd). 27, 45 The third one concerns Apostichopus japonicus sea cucumber exposed to six different antibiotics; 46 the fourth one concerns species Danio rerio exposed to arsenic (As). 47 Gestin and colleagues 27,45 used several one-compartment PBK models compared with one four-compartment PBK model to gain knowledge on the accumulation and fate dynamic of Cd in and between gammarids' organs.…”

Section: Case Studies In Ecotoxicologymentioning

confidence: 99%

“…Inspired from Gestin et al, 27,45 when considering only solid black arrows, Figure 3 highlights the target organs that can correspond to one compartment according to i: intestine (i = 1); cephalon (i = 2); caeca (i = 3); remaining tissues (i = 4). Each compartment has its own parameter pair for uptake (k u,i ) and elimination (k e,i ) rates (Table 2).…”

Section: Case Study With One Compartmentmentioning

confidence: 99%

Generic Solving of Physiologically-based Kinetic Models in Support of Next Generation Risk Assessment Due to Chemicals

Charles¹,

Gestin²,

Bruset³

et al. 2022

J Explor Res Pharmacol

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Increasing confidence in using in vitro and in silico model-based data to aid the chemical risk assessment process is one of the most significant challenges faced by regulatory authorities. A crucial concern is taking full advantage of scientifically valid physiologically-based kinetic (PBK) models. Nevertheless, risk assessors remain unwilling to employ PBK models in their daily work. Indeed, PBK models are not often included in current official guidance documents. In addition, most users have limited experience with modeling in general. So, the complexity of PBK models and a lack of evaluation methods for their performance certainly contribute to their limited use in practical risk assessment. This paper proposes an innovative and unified modeling framework for writing PBK equations as matrix ordinary differential equations (ODE) and their solutions, expressed with matrix products. This generic PBK solution considers as many state variables as needed to quantify chemical absorption, distribution, metabolism, and excretion processes within living organisms when exposed to chemical substances. This generic PBK model makes possible any compartmentalization to be considered, as well as all appropriate interconnections between compartments and with the external medium. We first introduce our PBK modeling framework, with all the intermediate steps from the matrix ODE to the exact solution. Then we apply this framework to bioaccumulation testing before illustrating its concrete use through complementary case studies regarding species, compounds, and model complexity.

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“…The ubiquitous gammarid Gammarus fossarum is widely used for this property, as it accumulates metals as a grazer of leaf litter and is an opportunistic predator of invertebrate prey (Kunz et al, 2010;Pellet et al, 2014;Filipović Marijić et al, 2016). Although the bioaccumulation processes of dissolved metals have been extensively documented (Vellinger et al, 2012;Urien et al, 2017;Gestin et al, 2022, less is known about the dietary assimilation and elimination of metals in this species. As exposure conditions are more difficult to standardise than for aqueous exposures, the dietary route in aquatic invertebrates is often poorly understood.…”

Section: Introductionmentioning

confidence: 99%

“…A toxicokinetic model for the aqueous pathway has already been developed for zinc and cadmium (Gestin et al, 2022). However, to be able to set up this kind of model considering the trophic pathway, it is important to have preliminary data concerning the AE of metals.…”

Section: Introductionmentioning

confidence: 99%

Assimilation efficiencies and elimination rates of silver, cadmium and zinc accumulated by trophic pathway in Gammarus fossarum

Gestin,

Lopes,

Delorme

et al. 2024

Peer Community Journal

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To improve the assessment of metal toxicity in aquatic organisms, it is important to consider the different uptake pathways (i.e. trophic or aqueous). The bioaccumulation of dissolved metals such as Cd and Zn in gammarids is beginning to be well described. However, there are very few data on the contribution of the dietary pathway, and its associated toxicokinetic parameters. Among these, the assimilation efficiency (AE) is an essential parameter for the implementation of models that take the trophic pathway into account. This study aims to estimate the assimilation efficiencies and elimination rates of two types of food, i.e. alder leaves and chironomid larvae, contaminated with three metals (Ag, Cd and Zn) of major concern for the Water Framework Directive (WFD). The pulse-chase-feeding method was used. Gammarids were fed with alder leaves or chironomid larvae previously contaminated with 110m Ag, 109 Cd or 65 Zn, for a short period of time (1 to 5 hours), followed by an elimination phase of 14 days. At different time points, the gammarids were placed alive on the gamma detector to individually quantify whole body concentrations of 110m Ag, 109 Cd or 65 Zn. Our results indicate that: i) Cd has the highest assimilation efficiency (39% for leaves and 19% for larvae), followed by Zn (15% for leaves and 9% for larvae) and Ag (5% for leaves); ii) for Cd and Zn, the AE were higher when gammarids were fed with leaves than with larvae; iii) the elimination rates of metals seem to depend more on the food matrix than on the metal assimilated; and thus iv) the biological half-life calculated from the k es is 5.1 days for Ag, between 4.9 and 13 days for Cd and between 3.8 and 13 days for Zn.

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Organ-specific accumulation of cadmium and zinc in Gammarus fossarum exposed to environmentally relevant metal concentrations

Cited by 13 publications

References 50 publications

DNA damage caused by light-driven graphene oxide: a new mechanism

DNA damage caused by light-driven graphene oxide: a new mechanism

Generic Solving of Physiologically-based Kinetic Models in Support of Next Generation Risk Assessment Due to Chemicals

Assimilation efficiencies and elimination rates of silver, cadmium and zinc accumulated by trophic pathway in Gammarus fossarum

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