Organ-On-A-Chip Database Revealed—Achieving the Human Avatar in Silicon

Abstract

Organ-on-a-chip (OOC) provides microphysiological conditions on a microfluidic chip, which makes up for the shortcomings of traditional in vitro cellular culture models and animal models. It has broad application prospects in drug development and screening, toxicological mechanism research, and precision medicine. A large amount of data could be generated through its applications, including image data, measurement data from sensors, ~omics data, etc. A database with proper architecture is required to help scholars in this field design experiments, organize inputted data, perform analysis, and promote the future development of novel OOC systems. In this review, we overview existing OOC databases that have been developed, including the BioSystics Analytics Platform (BAP) developed by the University of Pittsburgh, which supports study design as well as data uploading, storage, visualization, analysis, etc., and the organ-on-a-chip database (Ocdb) developed by Southeast University, which has collected a large amount of literature and patents as well as relevant toxicological and pharmaceutical data and provides other major functions. We used examples to overview how the BAP database has contributed to the development and applications of OOC technology in the United States for the MPS consortium and how the Ocdb has supported researchers in the Chinese Organoid and Organs-On-A-Chip society. Lastly, the characteristics, advantages, and limitations of these two databases were discussed.

Models for barrier understanding in health and disease in lab-on-a-chips

“…Organ-on-a-chip models must replicate certain tissue and organ structures and functions; hence, appropriate cell types and sources must be prepared and provided. Primary cells isolated from specific organs without any gene modification are considered ideal cell sources for organ-on-a-chips, as they exhibit comparable functions to in vivo environments 11 . However, in vitro culture of primary cells can be challenging for certain types, such as neurons and cardiomyocytes, and they may only be stably available for a limited time 12 .…”

The Upcoming Drift of Organ-Chip in Pharmacological Trial Investigate

“…Patient-derived pluripotent stem cells (iPSCs), which have recently come to light in research [31,32,33], For the production of autologous target organs or tissues, such as those obtained from skin fibroblasts, serve as an alternative and limitless cell source. This enables the development of patient-specific organ chips for personalised disease modelling and drug screening [34,35]. For instance, a human BBB chip created using neurons, astrocytes, and endothelial-like cells from brain microvessels generated from patient iPSCs showed patient-specific breakdown of barrier integrity and blood-to-brain permeability of pharmaceuticals.…”

Small Zoom Mismatch Adjustment Method for Dual-Band Fusion Imaging System Based on Edge-Gradient Normalized Mutual Information

“…Nevertheless, it is also vulnerable to falling into a local extremum, leading to search failure. Therefore, many studies are devoted to the improvement of this algorithm [34][35][36]. Guo et al proposed a method selecting the step size and peak according to the slope change in the search process [34].…”

“…Jiang et al proposed a hybrid search method combining hill-climbing search and function approximation algorithms. The small range is determined by the hillclimbing search algorithm, and then the peak is obtained by the function approximation algorithm [36]. These two methods improve the search accuracy to a certain extent, but they are complicated and not conducive to subsequent hardware research.…”