Organ donation in the US and Europe: The supply vs demand imbalance

Lewis, Amy; Koukoura, Angeliki; Tsianos, Georgios-Ioannis; Gargavanis, Athanasios; Nielsen, Anne Ahlmann; Vassiliadis, Efstathios

doi:10.1016/j.trre.2020.100585

Cited by 164 publications

(128 citation statements)

References 77 publications

Supporting

Mentioning

117

Contrasting

Unclassified

Order By: Relevance

“…Table 1 shows the prepared AG hydrogels with different concentrations of G solutions. The concentration in weight/volume percentage (w/v)% was calculated using Equation (1). The AG solutions were denoted as AG10:10, AG10:20, AG10:30, AG10:40, and AG10:50 according to their corresponding concentrations.…”

Section: Preparation Of Alginate-gelatin (Ag) Hydrogelsmentioning

confidence: 99%

“…Mostly, tissues and organs for transplantation have come from donations but mostly are not suitable in meeting clinical needs. According to the organ procurement and transplantation network (OPTN), there is a wide gap between the number of organs in demand and donated organs for transplantation, and this difference keeps significantly growing year by year [1][2][3]. To meet the enormous need for tissue and organ for transplantation, tissue engineering (TE) has emerged as an alternative and promising solution to develop and fabricate bio-substitutes of tissues and organs that can be used [4,5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Characterization of Alginate–Gelatin–Cholesteryl Ester Liquid Crystals Bioinks for Extrusion Bioprinting of Tissue Engineering Scaffolds

et al. 2022

View full text Add to dashboard Cite

Tissue engineering (TE) is an innovative approach to tackling many diseases and body parts that need to be replaced by developing artificial tissues and organs. Bioinks play an important role in the success of various TE applications. A bioink refers to a combination of a living cell, biomaterials, and bioactive molecules deposited in a layer-by-layer form to fabricate tissue-like structures. The research on bioink attempts to offer a 3D complex architecture and control cellular behavior that improve cell physical properties and viability. This research proposed a new multi-material bioink based on alginate (A), gelatin (G), and cholesteryl ester liquid crystals (CELC) biomaterials, namely (AGLC) bioinks. The development of AGLC was initiated with the optimization of different concentrations of A and G gels to obtain a printable formulation of AG gels. Subsequently, the influences of different concentrations of CELC with AG gels were investigated by using a microextrusion-based 3D bioprinting system to obtain a printed structure with high shape fidelity and minimum width. The AGLC bioinks were formulated using AG gel with 10% weight/volume (w/v) of A and 50% w/v G (AG10:50) and 1%, 5%, 10%, 20%, and 40% of CELC, respectively. The AGLC bioinks yield a high printability and resolution blend. The printed filament has a minimum width of 1.3 mm at a 1 mL/min extrusion rate when the A equals 10% w/v, G equals 50% w/v, and CELC equals 40% v/v (AGLC40). Polymerization of the AGLC bioinks with calcium (Ca2+) ions shows well-defined and more stable structures in the post-printing process. The physicochemical and viability properties of the AGLC bioinks were examined by FTIR, DSC, contact angle, FESEM, MTT assay, and cell interaction evaluation methods. The FTIR spectra of the AGLC bioinks exhibit a combination of characteristics vibrations of AG10:50 and CELC. The DSC analysis indicates the high thermal stability of the bioinks. Wettability analysis shows a reduction in the water absorption ability of the AGLC bioinks. FESEM analysis indicates that the surface morphologies of the bioinks exhibit varying microstructures. In vitro cytotoxicity by MTT assay shows the ability of the bioinks to support the biological activity of HeLa cells. The AGLC bioinks show average cell viability of 82.36% compared to the control (90%). Furthermore, cultured cells on the surface of AGLC bioinks showed that bioinks provide favorable interfaces for cell attachment.

show abstract

Section: Preparation Of Alginate-gelatin (Ag) Hydrogelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of Alginate–Gelatin–Cholesteryl Ester Liquid Crystals Bioinks for Extrusion Bioprinting of Tissue Engineering Scaffolds

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Scotland: Human Tissue (Authorisation) (Scotland) Act 2019. In force from Autumn 2020)] (Lewis et al, 2020;Jensen, 2019;Glazier, 2019). A recent publication indicates that presumed consent policy impacts donation rates, and it was significant in a European country (Shepherd, 2014).…”

Section: Donation Model Switchmentioning

confidence: 99%

“…Other factors include potential donor availability, transplantation infrastructure, health care spending, and public attitudes, as well as familial consent and donor registries. It is not proved the correlation between effective organ procurement rates and the role of legislation, but the suggestion that switching to an opt-out system may increase organ donation rates (Arshad, 2019;Willis, 2014;Lewis et al, 2020).…”

Section: Donation Model Switchmentioning

confidence: 99%

Correlation of Effective Organ Procurement Rates and the Role of Legislation in Individual European Countries

Kiel-Puślecka¹,

Puslecki²,

Dąbrowski³

et al. 2021

ERSJ

View full text Add to dashboard Cite

Purpose: Clinical transplantation has proven to be a lifesaving method since the last century. The shortage of donors and organs pool for transplantation is a worldwide subject of discussion and legislation. Design/Methodology/Approach: Authors did a critical review and identified actual donation models in individual European countries. Findings: Critical revision of the distribution of donation models in individual European countries were presented: no country has chosen the model of strict consent, 18 countries adopted a model of opt-out, of which 13 were based on a strict model of opposition, and five decided to use an extended opposition system. The extended consent model was adopted in 1/3 of European countries (14 countries), three European countries adopted the information solution, Bulgaria is the only country adopting a higher necessity model. Authors identified in European countries opt-in to opt-out movement trend and "hard" presumed consent paradox. Practical implications: Different models adopted in European countries and the shortage of organs for transplantation implicate some countries' transfer from opt-in to an opt-out model. It can benefit in increasing organ pool. Originality/value: The article includes the first complex and critical analysis of effective organ procurement and legislation models in European countries.

show abstract

“…Despite initiatives to improve access to transplantation, the worldwide demand for donor organs by far exceeds the current supply [1]. Without new approaches to transplantation, it is likely that a growing number of patients will continue to wait a very long time before receiving an organ, will remain on dialysis if they experience kidney failure or will die while waiting for a first or repeat solid organ transplant.…”

Section: Introductionmentioning

confidence: 99%

Organ transplants of the future: planning for innovations including xenotransplantation

et al. 2021

View full text Add to dashboard Cite

The future clinical application of animal-to-human transplantation (xenotransplantation) is of importance to society as a whole. Favourable preclinical data relevant to cell, tissue and solid organ xenotransplants have been obtained from many animal models utilizing genetic engineering and protocols of pathogen-free husbandry. Findings have reached a tipping point, and xenotransplantation of solid organs is approaching clinical evaluation, the process of which now requires close deliberation. Such discussions include considering when there is sufficient evidence from preclinical animal studies to start first-in-human xenotransplantation trials. The present article is based on evidence and opinions formulated by members of the European Society for Organ Transplantation who are involved in the Transplantation Learning Journey project. The article includes a brief overview of preclinical concepts and biology of solid organ xenotransplantation, discusses the selection of candidates for first-in-human studies and considers requirements for study design and conduct. In addition, the paper emphasizes the need for a regulatory framework for xenotransplantation of solid organs and the essential requirement for input from public and patient stakeholders.

show abstract

Organ donation in the US and Europe: The supply vs demand imbalance

Cited by 164 publications

References 77 publications

Characterization of Alginate–Gelatin–Cholesteryl Ester Liquid Crystals Bioinks for Extrusion Bioprinting of Tissue Engineering Scaffolds

Characterization of Alginate–Gelatin–Cholesteryl Ester Liquid Crystals Bioinks for Extrusion Bioprinting of Tissue Engineering Scaffolds

Correlation of Effective Organ Procurement Rates and the Role of Legislation in Individual European Countries

Organ transplants of the future: planning for innovations including xenotransplantation

Contact Info

Product

Resources

About