Organ Donation and Transplantation in India in 2019

Ramesh, Vasanthi; Pal, Chaitali

doi:10.6002/ect.2021.0105

Cited by 10 publications

(13 citation statements)

References 10 publications

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“…74 However in India, as of 2019, 550 transplant centers were already in operation with more than 12 000 solid organ transplants performed annually. 75 As solid organ transplants are increasingly performed around the world, more data is needed on the feasibility and applicability of ASP interventions and metrics globally.…”

Section: International Perspectivementioning

confidence: 99%

Antimicrobial stewardship in solid organ transplant recipients: Current challenges and proposed metrics

Raglow

Advani

Aitken

et al. 2022

Transplant Infectious Dis

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Background Solid organ transplant (SOT) recipients are challenging populations for antimicrobial stewardship interventions due to a variety of reasons, including immunosuppression, consequent risk of opportunistic and donor‐derived infections, high rates of infection with multi‐drug resistant organisms (MDROs), Clostridioides difficile, and need for prolonged antimicrobial prophylaxis. Despite this, data on stewardship interventions and metrics that address the distinct needs of these patients are limited. Methods We performed a narrative review of the current state of antimicrobial stewardship in SOT recipients, existing interventions and metrics in this population, and considerations for implementation of transplant‐specific stewardship programs. Results Antimicrobial stewardship metrics are evolving even in the general patient population. Data on metrics applicable to the SOT population are even more limited. Standard process, outcomes, and balancing metrics may not always apply to the SOT population. A successful stewardship program for SOT recipients requires reviewing existing data, applying general stewardship principles, and understanding the nuances of SOT patients. Conclusion As antimicrobial stewardship interventions are being implemented in SOT recipients; new metrics are needed to assess their impact. In conclusion, SOT patients present a challenging but important opportunity for antimicrobial stewards. Abbreviations SOT, antimicrobial stewardship program, MDRO, Clostridioides difficile infection, Centers for Disease Control and Prevention, Infectious Diseases Society of America, prospective audit and feedback, hematopoietic cell transplant, cytomegalovirus, trimethoprim‐sulfamethoxazole, surgical site infections, nucleic acid amplification testing, days of therapy, defined daily dose, and length of stay.

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Section: International Perspectivementioning

confidence: 99%

Antimicrobial stewardship in solid organ transplant recipients: Current challenges and proposed metrics

Raglow

Advani

Aitken

et al. 2022

Transplant Infectious Dis

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“…Of the total of 2592 liver transplants done in 2019 (before COVID), > 95% were done in 175 private sector hospitals and only <5% were done in 5 hospitals in the public sector. 1,2 Private hospitals perform 90% of all solid organ transplants and 98% of all liver transplants at a cost that is relatively low by international standards, approximately $ 7,500 US dollars for a kidney transplant and $25-30,000 for a liver transplant, but still well beyond the reach of most Indians who have an average annual income of less than $2000 US dollars. 2 Why is this so and what can be done about it?…”

mentioning

confidence: 99%

Why Are So Few Liver Transplants Done in the Public Sector in India and How Can We Improve the Numbers?

Nundy¹

2022

Journal of Clinical and Experimental Hepatology

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“…

organ transplantation has a high demand due to its large population base and high incidences of both communicable and noncommunicable diseases among its population. 1 India has the third largest number of transplants among countries. 1 Studies have shown that solid organ transplants (SOT) may save the lives of patients who are suffering from terminal organ failure and lead to an improved quality-of-life.

…”

mentioning

confidence: 99%

“…1 India has the third largest number of transplants among countries. 1 Studies have shown that solid organ transplants (SOT) may save the lives of patients who are suffering from terminal organ failure and lead to an improved quality-of-life. 2 A wide gap exists between patients who need transplants and the organs that are available in India.…”

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confidence: 99%

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Real-world utilization and acceptance of tacrolimus-based immunosuppression in solid organ transplant recipients in India

2022

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Background: To describe the patient characteristics and usage pattern of biosimilar bevacizumab for the treatment of metastatic colorectal cancer (mCRC) in India.Methods: This real-world, retrospective analysis included adult patients receiving biosimilar bevacizumab between April 2021 and March 2022.Results: A total of 1125 patients with mCRC who received biosimilar bevacizumab-based chemotherapy were included. The mean age at diagnosis was 57.8 years. Majority of the patients were males (71%) and belonged to the age groups of 41-76 years. The primary tumor site was right colon (52.6%) followed by left colon (29.2%) and rectum (17.3%), and the tumor grade was reported as high in most (88.7%) of the patients. Majority of patients received biosimilar bevacizumab-based chemotherapy as first-line therapy (61.3%), followed by second-line (31.9%) and third-line therapy (6.8%). In combination with biosimilar bevacizumab, FOLFOX (folinic acid, 5-fluorouracil, and oxaliplatin) was the most commonly administered regimen (42.9%), followed by CAPOX (capecitabine and oxaliplatin, 26.5%) and FOLFIRI (folinic acid, 5-fluorouracil, and irinotecan, 22.8%).Conclusions: Biosimilar bevacizumab-based chemotherapy is being widely used in real‑world clinical setting in India for the management of patients with mCRC.

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Organ Donation and Transplantation in India in 2019

Cited by 10 publications

References 10 publications

Antimicrobial stewardship in solid organ transplant recipients: Current challenges and proposed metrics

Antimicrobial stewardship in solid organ transplant recipients: Current challenges and proposed metrics

Why Are So Few Liver Transplants Done in the Public Sector in India and How Can We Improve the Numbers?

Real-world utilization and acceptance of tacrolimus-based immunosuppression in solid organ transplant recipients in India

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