Organ crosstalk during acute lung injury, acute respiratory distress syndrome, and mechanical ventilation

Quilez, María Elisa; López-Aguilar, Josefina; Blanch, Lluís

doi:10.1097/mcc.0b013e32834ef3ea

Cited by 55 publications

(47 citation statements)

References 37 publications

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“…25 Organ cross-talk is an emerging, interesting, and clinically relevant field. [26][27][28][29][30] Currently, little is known about the intrinsic pathway and pathophysiological mechanisms of medical complications cross-talk after acute stroke. Accumulating evidence indicated that acute stroke could induce significant immunologic changes such as stroke-induced immunodepression, 31,32 which was a key facilitating factor for poststroke infection, especially pneumonia.…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating evidence indicated that acute stroke could induce significant immunologic changes such as stroke-induced immunodepression, 31,32 which was a key facilitating factor for poststroke infection, especially pneumonia. Meanwhile, we can learn important lessons from studies on postinjury multiple organ dysfunction syndrome, in which pneumonia or acute lung injury has been described as the pacemaker of multiple organ failure 26,33,34 and could induce multiple organ dysfunction syndrome by releasing inflammatory mediators into bloodstream (biotrauma). 33,[35][36][37][38][39] Based on these indirect evidences, we speculated that association between pneumonia and development of nonpneumonia medical complications after acute stroke might be medicated by systemic immunologic response and inflammatory mediators (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

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Interrelationship Among Common Medical Complications After Acute Stroke

Wang

Shen³

et al. 2013

Stroke

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Although several studies have systematically investigated medical complications after stroke, 3,5-13 much attention was paid to specific complications and few studies have focused on investigating the potential interrelationship among them. In daily clinical practice, it is common for patients with stroke to experience multiple medical complications (≥2) during acute hospitalization, especially for those patients with severe neurological deficit. 11,14,15 It is still unclear whether these strokeassociated medical complications occur independently or not, and if not, what is the potential association among them? The answers to these questions might shed some light on uncovering pathophysiological mechanisms underlying multiple medical complications after acute stroke and developing novel preventive strategies to improve stroke outcome.In the present study, we aimed to examine the correlation and association between common medical complications after acute stroke. To draw convincing conclusions, we tested our findings in acute ischemic stroke (AIS) and spontaneous intracerebral hemorrhage (ICH) cohorts, respectively.Background and Purpose-Medical complications are common among patients with stroke. However, little is known about the potential interrelationship among them. In the present study, we aimed to investigate the association between common in-hospital medical complications after acute ischemic stroke (AIS) and spontaneous intracerebral hemorrhage (ICH

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interrelationship Among Common Medical Complications After Acute Stroke

Wang

Shen³

et al. 2013

Stroke

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“…Furthermore, this evidence indicates that the lung, heart, and brain are intrinsically linked during this transitional period (4), whereby lung injury or the initiation of an inflammatory response within the lung can have direct and indirect effects on the cardiovascular system, systemic circulation, and cerebral circulation. Indeed, the concept of multiple-organ interrelationships in ventilated patients with severe respiratory disorders is well established in the literature regarding adults (5,6). However, although similarities between the association of brain injury and ventilation can be drawn between adults and preterm newborns, the uniqueness of the transitioning circulation at birth provides additional mechanisms/pathways for brain injury to occur.…”

Section: Preterm Birth and The Requirement For Ventilationmentioning

confidence: 99%

Respiratory support for premature neonates in the delivery room: effects on cardiovascular function and the development of brain injury

et al. 2014

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“…[12][13][14][15] Since cognitive disturbances after sepsis and ARDS are common and potentially modifiable, there is a remarkable growing interest in elucidating mechanisms underlying the interaction between the lung and the brain 14,15 during critical illness. Our study was aimed to explore the response of astrocytes and cortical neurons to mediators released by lipopolysaccharide (LPS)-activated human lung epithelial cells, in a well-established in vitro approach based on the first steps in the development of sepsis and sepsis-induced ARDS.…”

mentioning

confidence: 99%

Endotoxin-induced lung alveolar cell injury causes brain cell damage

Rodríguez-González

Ramos-Nuez

Martin‐Barrasa

et al. 2014

Exp Biol Med (Maywood)

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Sepsis is the most common cause of acute respiratory distress syndrome, a severe lung inflammatory disorder with an elevated morbidity and mortality. Sepsis and acute respiratory distress syndrome involve the release of inflammatory mediators to the systemic circulation, propagating the cellular and molecular response and affecting distal organs, including the brain. Since it has been reported that sepsis and acute respiratory distress syndrome contribute to brain dysfunction, we investigated the brain-lung crosstalk using a combined experimental in vitro airway epithelial and brain cell injury model. Conditioned medium collected from an in vitro lipopolysaccharide-induced airway epithelial cell injury model using human A549 alveolar cells was subsequently added at increasing concentrations (no conditioned, 2%, 5%, 10%, 15%, 25%, and 50%) to a rat mixed brain cell culture containing both astrocytes and neurons. Samples from culture media and cells from mixed brain cultures were collected before treatment, and at 6 and 24 h for analysis. Conditioned medium at 15% significantly increased apoptosis in brain cell cultures 24 h after treatment, whereas 25% and 50% significantly increased both necrosis and apoptosis. Levels of brain damage markers S100 calcium binding protein B and neuron-specific enolase, interleukin-6, macrophage inflammatory protein-2, as well as matrix metalloproteinase-9 increased significantly after treating brain cells with !2% conditioned medium. Our findings demonstrated that human epithelial pulmonary cells stimulated with bacterial lipopolysaccharide release inflammatory mediators that are able to induce a translational clinically relevant and harmful response in brain cells. These results support a brain-lung crosstalk during sepsis and sepsis-induced acute respiratory distress syndrome.

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Organ crosstalk during acute lung injury, acute respiratory distress syndrome, and mechanical ventilation

Cited by 55 publications

References 37 publications

Interrelationship Among Common Medical Complications After Acute Stroke

Interrelationship Among Common Medical Complications After Acute Stroke

Respiratory support for premature neonates in the delivery room: effects on cardiovascular function and the development of brain injury

Endotoxin-induced lung alveolar cell injury causes brain cell damage

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