Organ Crosstalk Contributes to Muscle Wasting in Chronic Kidney Disease

Wang, Xiaonan H.; Price, S. Russ

doi:10.1016/j.semnephrol.2023.151409

Seminars in Nephrology

2023

DOI: 10.1016/j.semnephrol.2023.151409

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Organ Crosstalk Contributes to Muscle Wasting in Chronic Kidney Disease

Xiaonan H. Wang,

S. Russ Price

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Cited by 2 publications

References 127 publications

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Introduction: Advances in Nutrition Management in Chronic Kidney Disease

Wang

2023

Seminars in Nephrology

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Introduction: Advances in Nutrition Management in Chronic Kidney Disease

Wang

2023

Seminars in Nephrology

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Exercise and nutrition interventions for renal cachexia

Slee,

Reid

2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Renal cachexia is a deleterious condition characterized by weight loss, muscle wasting and loss of physical function, quality of life, and increased mortality. Multimodal treatment strategies utilizing exercise and nutrition interventions have been recently suggested although the evidence base is still in its infancy. This paper aimed to review the current literature surrounding the use of exercise and nutrition for renal cachexia. Main findings Evidence from systematic reviews and narrative reviews indicates that resistance training (RT) is proven to have beneficial effects on improving muscle strength and in some cases physical function, although effects on muscle mass are mixed and inconclusive. Further, combined RT and aerobic training (AT) may have also beneficial effects on overall functional capacity and there appears to be no superior mode of protocol (inter/intra-dialysis vs. home-based). For nutrition, there is new data from systematic review of studies indicating that oral nutritional supplementation (ONS) may have beneficial effects on nutritional status (e.g. body mass index, plasma albumin and handgrip strength). Omega-3 fatty acids have been shown to have anti-inflammatory effects in haemodialysis patients from two recent systematic reviews, and evidence from other populations groups indicate they may be beneficial for improving muscle mass and strength. Summary Evidence is accumulating for individual exercise and nutrition components but specific multimodal treatment studies in renal cachexia need to be urgently undertaken.

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Organ Crosstalk Contributes to Muscle Wasting in Chronic Kidney Disease

Cited by 2 publications

References 127 publications

Introduction: Advances in Nutrition Management in Chronic Kidney Disease

Introduction: Advances in Nutrition Management in Chronic Kidney Disease

Exercise and nutrition interventions for renal cachexia

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