Organ and tissue-specific distribution of selected polycyclic aromatic hydrocarbons (PAHs) in ApoE-KO mouse

Jin, Xin; Hua, Qiaoyi; Liu, Yanan; Wu, Zhijun; Xu, Deshu; Ren, Qidong; Zhao, Wenjin; Guo, Xuejun

doi:10.1016/j.envpol.2021.117219

Cited by 27 publications

(11 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Differences in the accumulation of PAHs may result also from the chemical structure of these compounds. For example, in mice, it was observed that PAHs with a higher molecular weight and lower water solubility were less likely to bioaccumulate [ 31 ]. In French patients, we observed a significant positive correlation between the concentrations of naphthalene in all three types of AT with BMI.…”

Section: Discussionmentioning

confidence: 99%

“…Due to their lipophilicity, PAHs have the potential to be absorbed and accumulated by living organisms. So far, several studies have shown that PAHs can accumulate in rodents [ 30 , 31 ] pigs, cows [ 32 ] and human adipose tissue (AT) [ 33 , 34 , 35 ]. Moreover, it is known that some of them may change the levels of promoter methylation of genes involved in glucose and lipid metabolism, especially the insulin receptor gene, contributing to the pathogenesis of insulin resistance [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Concentration of Polycyclic Aromatic Hydrocarbons (PAHs) in Human Serum and Adipose Tissues and Stimulatory Effect of Naphthalene in Adipogenesis in 3T3-L1 Cells

Mlyczyńska

Bongrani

Ramé

et al. 2023

IJMS

View full text Add to dashboard Cite

Polycyclic aromatic hydrocarbons (PAHs) are one of the most prevalent classes of environmental pollutants. Some evidence shows that PAHs could be involved in human obesity. However, little is known about the distribution patterns of PAHs in human adipose tissue (AT) and the role of PAHs on adipogenesis/lipogenesis. The aims of this pilot study were to determine concentrations of 16 PAHs defined as high-priority pollutants in the plasma and adipose tissue of French and Polish bariatric patients, as well as their correlation with body mass index (BMI), plasma and AT adipokines expression levels. We finally investigated the role of naphthalene on cell proliferation, viability, and differentiation in 3T3-L1 preadipocytes. The concentration of most PAHs was similar in the three types of AT and it was significantly higher in AT as compared to plasma, suggesting bioaccumulation. Polish patients had higher PAH levels in AT than French ones. Only the concentration of naphthalene in AT was positively correlated with the BMI and serum or adipose chemerin, adiponectin and resistin expression, in French but not in Polish patients, who had significantly higher BMIs. Moreover, naphthalene exposure increased the cell proliferation of 3T3-L1 preadipocytes and lipogenesis, and increased the expression of genes involved in adipogenesis after cell differentiation. Taken together, PAHs and more particularly naphthalene could be an obesogenic molecule and increase the risk of obesity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Concentration of Polycyclic Aromatic Hydrocarbons (PAHs) in Human Serum and Adipose Tissues and Stimulatory Effect of Naphthalene in Adipogenesis in 3T3-L1 Cells

Mlyczyńska

Bongrani

Ramé

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…After entering the body, except for a small part of BaP excreted in the feces in its original form, most of the BaP accumulated in the gastrointestinal tract, epididymal fat, lung, liver, brain, and kidney ( 13 ). BaP is highly lipophilic and can be easily absorbed into cells through the plasma membrane.…”

Section: Sources Metabolism and Tissue Toxicity Of Bapmentioning

confidence: 99%

“…However, it is only in recent years, the cardiovascular toxicity of BaP attracted considerable attention. Currently, as an independent risk factor for CVDs, BaP has been found to be closely related to CVDs, including AS, HTN and AAA, and shows multiple kinds of vascular toxicity ( 10 , 11 , 13 , 42 ). Preclinical studies have found that BaP exposure is correlated with oxidative stress and vascular toxicity.…”

Section: Vascular Toxicity Effects and Underlying Mechanism Of Bapmentioning

confidence: 99%

“…Moreover, the BPDE-DNA adduct could also be observed in the aorta tissues ( 47 ), while compared to the control groups, 12–24 weeks of treatment increased the expression of monocyte chemoattractant protein 1 (MCP1), and promoted the release of transforming growth factor beta (TGFβ) and tumor necrosis factor α (TNFα) in vascular wall cells ( 48 – 50 ). In response to the inflammatory mediator, the atherosclerosis lesion may be heavily infiltrated with pro-inflammation cells, including macrophages, T cells and neutrophils ( 49 ), and the lesion size began to enlarge ( 13 , 50 ).…”

Section: Vascular Toxicity Effects and Underlying Mechanism Of Bapmentioning

confidence: 99%

See 1 more Smart Citation

Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

Benzo(a)pyrene (BaP) is a highly toxic and carcinogenic polycyclic aromatic hydrocarbon (PAH) whose toxicological effects in the vessel-wall cells have been recognized. Many lines of evidence suggest that tobacco smoking and foodborne BaP exposure play a pivotal role in the dysfunctions of vessel-wall cells, such as vascular endothelial cell and vascular smooth muscle cells, which contribute to the formation and worsening of cardiovascular diseases (CVDs). To clarify the underlying molecular mechanism of BaP-evoked CVDs, the present study mainly focused on both cellular and animal reports whose keywords include BaP and atherosclerosis, abdominal aortic aneurysm, hypertension, or myocardial injury. This review demonstrated the aryl hydrocarbon receptor (AhR) and its relative signal transduction pathway exert a dominant role in the oxidative stress, inflammation response, and genetic toxicity of vessel-wall cells. Furthermore, antagonists and synergists of BaP are also discussed to better understand its mechanism of action on toxic pathways.

show abstract

Polyaromatic hydrocarbon removal from wastewater using sustainable carbon-based adsorbents: A recent update

Goveas,

Nagendran,

Selvaraj

et al. 2024

Clean Techn Environ Policy

View full text Add to dashboard Cite

Organ and tissue-specific distribution of selected polycyclic aromatic hydrocarbons (PAHs) in ApoE-KO mouse

Cited by 27 publications

References 49 publications

Concentration of Polycyclic Aromatic Hydrocarbons (PAHs) in Human Serum and Adipose Tissues and Stimulatory Effect of Naphthalene in Adipogenesis in 3T3-L1 Cells

Concentration of Polycyclic Aromatic Hydrocarbons (PAHs) in Human Serum and Adipose Tissues and Stimulatory Effect of Naphthalene in Adipogenesis in 3T3-L1 Cells

Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism

Polyaromatic hydrocarbon removal from wastewater using sustainable carbon-based adsorbents: A recent update

Contact Info

Product

Resources

About