Abstract:In that work, ORF8 was characterized as a notable SARS-CoV-2 protein able to downregulate the function of MHC-I (Zhang et al., 2021) and which shares structural similarities with human immunoglobulins (including interleukins) that can eventually produce immune dysregulation (Valcarcel et al., 2021). It is not still clear if all COVID-19 patients are equally susceptible to this ORF8-mediated immune dysregulation, but Down syndrome (Ds) patients with COVID-19 have more health complications, such as cardiac dise… Show more
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