Orexin Regulates Glucose Homeodynamics with Daily Rhythm

Tsuneki, Hiroshi; Wada, Tsutomu; Sasaoka, Toshiyasu

doi:10.1007/978-3-319-23078-8_21

Cited by 1 publication

(1 citation statement)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Orexin deficiency causes sleep/wake-state instability, resulting in narcolepsy (Tsuneki et al, 2018). Some studies have also indicated that excessive sleep inhibits the metabolism of the brain, resulting in increased amyloid deposition and other harmful factors (Ju et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Excessive sleep increased the risk of incidence of cognitive impairment among older Chinese adults: a cohort study based on the Chinese Longitudinal Healthy Longevity Survey (CLHLS)

Zhang

Chen

et al. 2021

Int. Psychogeriatr.

View full text Add to dashboard Cite

Study objectives: Based on a cohort from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), we aimed to evaluate the relationship between sleep duration and the incidence of cognitive impairment among older Chinese adults. Methods: We conducted a prospective analysis based on 3692 participants from the CLHLS at baseline (in 2011), and as a 3-year follow-up (till 2014), 531 participants (14.4%) had cognitive impairment, which was defined as a Mini-Mental State Examination score <24. Sleep duration was classified into three groups: short (≤5 hours/day), normal (>5 but <10 hours), and long (≥10 hours/day). A logistic regression model was used to examine the association between baseline sleep duration and cognitive impairment after adjusting for sociodemographic data, living habits, and health conditions. Results: Five hundred sixty-two participants (15.2%) were in the short-duration group, and 608 participants (16.5%) were in the long-duration group. After adjusting for multiple potential confounders, compared with normal sleep duration, long sleep duration was associated with the incidence of cognitive impairment (OR = 1.309, 95% CI: 1.019–1.683), especially among men (OR = 1.527, 95% CI: 1.041–2.240) and those having a primary and above education level (OR = 1.559, 95% CI: 1.029–2.361). No significant association was observed between short sleep duration and cognitive impairment (OR = 0.860, 95% CI: 0.646–1.145). Conclusions: Excessive sleep may increase the risk of cognitive impairment in older individuals. It may be a suggestive sign of early neurodegeneration and may be a useful clinical tool to identify those at a higher risk of progressing to cognitive impairment.

show abstract

Section: Discussionmentioning

confidence: 99%