Orexin-induced food intake involves neuropeptide Y pathway

Yamanaka, Akihiro; Kunii, Kaiko; Nambu, Tadahiro; Tsujino, Natsuko; Sakai, Ai; Matsuzaki, Ichiyo; Miwa, Yoshiro; Goto, Katsutoshi; Sakurai, Takeshi

doi:10.1016/s0006-8993(00)02043-6

Cited by 237 publications

(145 citation statements)

References 22 publications

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“…In agreement with the present results, it has been reported that BIBO 3304 inhibits NPY, (Leu 31 ,Pro 34 )NPY and NPY(2 ± 36) induced as well as fasting induced food intake in rats (Polidori et al, 2000;Wieland et al, 1998). The compound also inhibits the hyperphagia after orexin-A administration (Yamanaka et al, 2000), but not that NPY induced feeding in guinea-pigs A. Lecklin et alobtained after galanin or norepinephrine (Wieland et al, 1998).…”

Section: British Journal Of Pharmacology Vol 135 (8)supporting

confidence: 93%

Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig

Lecklin

Lundell

Paananen

et al. 2002

British J Pharmacology

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1 Neuropeptide Y (NPY) is one of the most potent stimulants of food intake. It has been debated which receptor subtype mediates this response. Initially Y 1 was proposed, but later Y 5 was announced as a`feeding' receptor in rats and mice. Very little is known regarding other mammals. The present study attempts to characterize the role of NPY in feeding behaviour in the distantly related guinea-pig. When infused intracerebroventricularly, NPY dose-dependently increased food intake. 2 PYY, (Leu 31 ,Pro 34 )NPY and NPY(2 ± 36) stimulated feeding, whereas NPY(13 ± 36) had no e ect. These data suggest that either Y 1 or Y 5 receptors or both may mediate NPY induced food intake in guinea-pigs. 3 The Y 1 receptor antagonists, BIBO 3304 and H 409/22 displayed nanomolar a nity for the Y 1 receptor (K i values 1.1+0.2 nM and 5.6+0.9 nM, respectively), but low a nity for the Y 2 or Y 5 receptors. When guinea-pigs were pretreated with BIBO 3304 and H 409/22, the response to NPY was inhibited. 4 The Y 5 antagonist, CGP 71683A had high a nity for the Y 5 receptor (K i 1.3+0.05 nM) without having any signi®cant activities at the Y 1 and Y 2 receptors. When CGP 71683A was infused into brain ventricles, the feeding response to NPY was attenuated. 5 The present study shows that NPY stimulates feeding in guinea-pigs through Y 1 and Y 5 receptors. As the guinea-pig is very distantly related to the rat and mouse, this suggests that both Y 1 and Y 5 receptors may mediate NPY-induced hyperphagia also in other orders of mammals.

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Section: British Journal Of Pharmacology Vol 135 (8)supporting

confidence: 93%

Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig

Lecklin

Lundell

Paananen

et al. 2002

British J Pharmacology

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“…Orexins were shown to inhibit the VMH glucoreceptor neurons, while excite the arcuate nucleus (ARC) NPY neurons and the LHA MCH neurons [42][43][44] . Furthermore, local application of orexin in the PVH, DMH, and LHA was shown to increase food intake 45,46 .…”

Section: -1 Orexin and Feeding Behaviormentioning

confidence: 99%

Roles of orexins in the regulation of body weight homeostasis

Sakurai

2014

Obesity Research & Clinical Practice

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running title, Orexin and body weight homeostasis key words, orexin, hypothalamus, feeding, arousal, body weight 1 AbstractLateral hypothalamic neuropeptides, orexins, have been recognized as one of the most important regulators of sleep/wakefulness states. Besides, these peptides are also regarded as an important factor that regulates feeding behavior, owing to their localization within the lateral hypothalamic area, the classic "feeding center", pharmacological activities, and the fact that prepro-orexin mRNA is upregulated when animals are fasted. This review summarizes the role of orexins in the regulation of feeding behavior and body weight homeostasis in relation to other systems that involve orexinergic neurotransmission.

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“…Orexin-A and -B are orexigenic peptides produced in cell bodies located in the lateral hypothalamus (20). The orexin-1 receptor is localized in the NPYcontaining neurons in the ARC (21) and orexin-induced feeding is inhibited by NPY Y1 and/or Y5 receptor antagonists (22)(23)(24), suggesting that orexin could elicit feeding via these NPY neurons. Therefore, the second aim of the present study was to examine whether a subset of the NPY neurons in the ARC could serve as the common target for ghrelin, leptin, and orexins.…”

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confidence: 99%

Ghrelin Directly Interacts With Neuropeptide-Y-Containing Neurons in the Rat Arcuate Nucleus

et al. 2003

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Ghrelin is a newly discovered peptide that is released from the stomach and from neurons in the hypothalamic arcuate nucleus (ARC) and potently stimulates growth hormone release and food intake. Neuropeptide-Y (NPY) neurons in the ARC play an important role in the stimulation of food intake. The present study aimed to determine whether ghrelin directly activates NPY neurons and, if so, to explore its signaling mechanisms. Whether the neurons that respond to ghrelin could be regulated by orexin and leptin was also examined. G hrelin, an endogenous ligand for the growth hormone secretagogue (GHS) receptor (GHSR), is synthesized abundantly in the stomach and to a much lesser extent in the hypothalamic arcuate nucleus (ARC) (1). Peripheral or intracerebroventricular (ICV) injection of ghrelin releases growth hormone, stimulates food intake, and increases body weight in mice, rats, and humans (1-8). ICV injection of antighrelin IgG suppresses starvation-induced feeding (3). The daily pattern of plasma ghrelin levels in normal humans is characterized by a preprandial rise and postprandial fall (9). These findings have suggested that ghrelin plays a physiological role in the meal initiation.The neuropeptide-Y (NPY)-containing neurons localized in the ARC have been implicated in the stimulation of food intake-injection of NPY into the hypothalamus of rats potently stimulates food intake (10), and NPY secretion in the hypothalamus is increased during fasting (11). Regarding a possible link between ghrelin and the NPY neurons in the ARC, it has been shown that GHSR mRNA is expressed in 94% of the NPY neurons in the ARC by double-labeling in situ hybridization histochemistry (12). Systemic or ICV administration of ghrelin causes the ARC neurons to express Fos and Egr-1 (3,13-15) and ϳ90% of these Fos-positive neurons express NPY mRNA (13). Moreover, ghrelin increases the expression of NPY mRNA (3-5), and ICV administration of a NPY Y1 antagonist suppresses the ghrelin-stimulated food intake (3-5,15). These findings suggest that the NPY neurons in the ARC could be an important effector for the orexigenic action of ghrelin.

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Orexin-induced food intake involves neuropeptide Y pathway

Cited by 237 publications

References 22 publications

Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig

Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig

Roles of orexins in the regulation of body weight homeostasis

Ghrelin Directly Interacts With Neuropeptide-Y-Containing Neurons in the Rat Arcuate Nucleus

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Orexin-induced food intake involves neuropeptide Y pathway

Cited by 237 publications

References 22 publications

Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea‐pig

Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea‐pig

Roles of orexins in the regulation of body weight homeostasis

Ghrelin Directly Interacts With Neuropeptide-Y-Containing Neurons in the Rat Arcuate Nucleus

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Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig

Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig