Oregonator generalization as a minimal model of quorum sensing in Belousov–Zhabotinsky reaction with catalyst confinement in large populations of particles

Szabo, Erik

doi:10.1039/c5ra12841b

Cited by 2 publications

(2 citation statements)

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“…Synthetic quorum sensing might be exploited in biotechnology to induce a sharp change in state in response to a change in a density or group size in, for example, targeted drug delivery. Collective behaviour has been extensively investigated in inorganic catalytic particles and more complex behaviours than reported here are possible [47,48]. However, for applications in medicine biocompatible rsif.royalsocietypublishing.org J. R. Soc.…”

Section: Discussionmentioning

confidence: 99%

Switches induced by quorum sensing in a model of enzyme-loaded microparticles

Bánsági¹,

Taylor²

2018

J. R. Soc. Interface.

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4Quorum sensing refers to the ability of bacteria and other single-celled organisms to respond to 5 changes in cell density or number with population-wide changes in behaviour. Here, simulations were 6 performed to investigate quorum sensing in groups of diffusively-coupled enzyme microparticles using 7 a well characterised autocatalytic reaction which raises the pH of the medium: hydrolysis of urea by 8 urease. The enzyme urease is found in both plants and microorganisms and has been widely exploited 9 in engineering processes. We demonstrate how increases in group size can be used to achieve a 10 sigmoidal switch in pH at high enzyme loading, oscillations in pH at intermediate enzyme loading and 11 a bistable, hysteretic switch at low enzyme loading. Thus, quorum sensing can be exploited to obtain 12 different types of response in the same system, depending on the enzyme concentration. The 13 implications for microorganisms in colonies are discussed and the results could help in the design of 14 synthetic quorum sensing for biotechnology applications such as drug delivery. 15 16

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Section: Discussionmentioning

confidence: 99%

Switches induced by quorum sensing in a model of enzyme-loaded microparticles

Bánsági¹,

Taylor²

2018

J. R. Soc. Interface.

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“…The design of reaction networks that mimic the feedback-driven behavior of biological systems remains a formidable challenge. There has been increasing interest in obtaining quorum sensing type behavior in synthetic systems [5,12,33,34,35,36,37]. The underlying processes are vastly different however all examples exploit seemingly similar principles of an autocatalytic signaling process and communication between entities via a common surround.…”

Section: Discussionmentioning

confidence: 99%

Modelling Bacteria-Inspired Dynamics with Networks of Interacting Chemicals

Bánsági

Taylor

2019

Life

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One approach to understanding how life-like properties emerge involves building synthetic cellular systems that mimic certain dynamical features of living cells such as bacteria. Here, we developed a model of a reaction network in a cellular system inspired by the ability of bacteria to form a biofilm in response to increasing cell density. Our aim was to determine the role of chemical feedback in the dynamics. The feedback was applied through the enzymatic rate dependence on pH, as pH is an important parameter that controls the rates of processes in cells. We found that a switch in pH can be used to drive base-catalyzed gelation or precipitation of a substance in the external solution. A critical density of cells was required for gelation that was essentially independent of the pH-driven feedback. However, the cell pH reached a higher maximum as a result of the appearance of pH oscillations with feedback. Thus, we conclude that while feedback may not play a vital role in some density-dependent behavior in cellular systems, it nevertheless can be exploited to activate internally regulated cell processes at low cell densities.

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Oregonator generalization as a minimal model of quorum sensing in Belousov–Zhabotinsky reaction with catalyst confinement in large populations of particles

Abstract: The Oregonator demonstrates that quorum sensing in populations of Belousov–Zhabotinsky oscillators arises from modification of the stoichiometry by catalyst confinement.

Cited by 2 publications

References 86 publications

Switches induced by quorum sensing in a model of enzyme-loaded microparticles

Switches induced by quorum sensing in a model of enzyme-loaded microparticles

Modelling Bacteria-Inspired Dynamics with Networks of Interacting Chemicals

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