Ordered mesoporous carbon modified carbon ionic liquid electrode for the electrochemical detection of double-stranded DNA

Zhu, Zhihong; Xia, Li; Zeng, Yan; Sun, Wei

doi:10.1016/j.bios.2010.03.019

Cited by 58 publications

(23 citation statements)

References 40 publications

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“…It could be clearly observed that the peak potentials decreased with the increase of pH and obeyed a good linear equation of E pa (V) = À0.057pH + 1.4 (g = 0.993) (Inset in Figure 4). The slop of 57 mV/pH was very close to the theoretically expected value of 59 mV/pH, suggesting that the number of the proton participated in the electrochemical oxidation of guanine residues in dsDNA was equal to the number of electron-transfer, and this proton-coupled electron transfer process has been well identified in the electrochemical oxidation of DNA [22,23,35]. Additionally, with the increase of the pH values, the peak currents of the guanine residues increased gradually, and the largest peak current occurred at pH 8.0.…”

Section: Effect Of Acidity On the Electrochemical Behaviour Of Dsdnasupporting

confidence: 61%

“…Compared with the values in literature [22,33,34], the larger K s obtained herein also indicated the higher electrocatalysis of the GR material to guanine residues of dsDNA.…”

supporting

confidence: 63%

“…The detection limit was then estimated to be 0.35 mg mL À1 (3s), which was obviously lower than the values reported in literatures [22,23,38].…”

mentioning

confidence: 92%

“…It has been well known that the investigation on the electrochemical oxidation of dsDNA has shown great interests in the fields of biochemistry and bio-analytical chemistry [20,21]. But because the electroactive bases are embedded in the double helix of dsDNA, the electrooxidation potential of dsDNA is usually high and the gained sensitivity is low [22], and a pretreatment step of hydrolysis or denaturation is often involved [19,23].…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Oxidation of Native Double‐Stranded DNA on a Graphene‐Modified Glassy Carbon Electrode

et al. 2011

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The electrochemistry of double-stranded DNA (dsDNA) was investigated on a graphene-modified glassy carbon electrode (GR/GCE). Electrochemical characterization showed that GR on GCE surface significantly enhanced the specific surface area and electrical conductivity of the sensing platform. On GR/GCE, the electrooxidation peak of guanine residues in dsDNA was obviously enhanced and the peak potential was significantly lowered as compared to bare GCE. The electrochemical parameters and influence factors for measurements were investigated. Under the optimal conditions, the peak current linearly increased with dsDNA concentrations in the range from 1 to 500 mg mL À1 with a detection limit of 0.35 mg mL À1.

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Section: Effect Of Acidity On the Electrochemical Behaviour Of Dsdnasupporting

confidence: 61%

“…Compared with the values in literature [22,33,34], the larger K s obtained herein also indicated the higher electrocatalysis of the GR material to guanine residues of dsDNA.…”

supporting

confidence: 63%

“…The detection limit was then estimated to be 0.35 mg mL À1 (3s), which was obviously lower than the values reported in literatures [22,23,38].…”

mentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Electrochemical Oxidation of Native Double‐Stranded DNA on a Graphene‐Modified Glassy Carbon Electrode

et al. 2011

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“…10-600 ng mL −1 1.2 ng mL −1 Differential pulse voltammetry [31] Thionin-functionalized multiple graphene aerogel and gold nanostars 100 fg · mL −1 -10 ng⋅mL −1 39 fg · mL −1 Differential pulse voltammetric Present work MGA with GNS leads to an enhanced sensitivity. During the electrode reaction, the MGA-n plays very important roles in the electro-catalytic activity to oxidation and reduction of thionin.…”

Section: Comparison Of Different Materialsmentioning

confidence: 99%

Ultrasensitive direct detection of dsDNA using a glassy carbon electrode modified with thionin-functionalized multiple graphene aerogel and gold nanostars

et al. 2016

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The paper reports on the synthesis of a composite consisting of thionin-functionalized multiple graphene aerogel and gold nanostars (termed TF-MGA/GNSs). The composite displays an enhanced electrochemical performance compared to the classical graphene aerogel. The performance can be further improved by increasing number of the graphene oxide gelation cycles. The composite was deposited on a glassy carbon electrode to obtain a biosensor for the direct detection of dsDNA. The interaction of thionin with dsDNA causes a specific electrochemical response, best at a working voltage of −228 mV (vs. Ag/AgCl). The enhanced electrocatalytic activity of the composite strongly improves sensitivity. The differential pulse voltammetric signal linearly decreases with increasing dsDNA concentration in the range from 100 fg · mL −1 to 10 ng · mL −1 , and the detection limit is 39 fg · mL −1 (at an S/N ratio of 3). The method is sensitive, selective and rapid. It was successfully applied to the detection of circulating free DNA in human serum. The study also provides an attractive approach towards graphene aerogel-based materials to meet the needs of nanoelectronics for molecule diagnosis, bioanalysis and catalysis.

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Electrochemical Sensors Based on Ordered Mesoporous Carbons

Zhou

2016

Advanced Electrode Materials

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Ordered mesoporous carbon modified carbon ionic liquid electrode for the electrochemical detection of double-stranded DNA

Cited by 58 publications

References 40 publications

Electrochemical Oxidation of Native Double‐Stranded DNA on a Graphene‐Modified Glassy Carbon Electrode

Electrochemical Oxidation of Native Double‐Stranded DNA on a Graphene‐Modified Glassy Carbon Electrode

Ultrasensitive direct detection of dsDNA using a glassy carbon electrode modified with thionin-functionalized multiple graphene aerogel and gold nanostars

Electrochemical Sensors Based on Ordered Mesoporous Carbons

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