Ordered growth of neurons on diamond

Specht, Christian G.; Williams, Oliver A.; Jackman, Richard B.; Schoepfer, Ralf

doi:10.1016/j.biomaterials.2003.11.006

Cited by 145 publications

(118 citation statements)

References 19 publications

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“…The deposition of thin films of nanocrystalline diamond (NCD) onto materials leaves the overall texture of specimen greatly unchanged while allocating a variety of properties of natural diamond to the substrate surface. Yet due to the nanotopography of NCD, the resulting surface is enlarged and in combination with further refinement, such as the termination of the dangling bonds of the carbon atoms, proliferation and differentiation of cells can be influenced in a controlled manner [1,2]. Because the NCD surface is open to additional complex chemical refinement, it became conceivable for us to design medical implants that allow stable binding of molecules, such as bone morphogenetic protein-2 (BMP-2) [3,4].…”

Section: Introductionmentioning

confidence: 99%

The role of oxygen termination of nanocrystalline diamond on immobilisation of BMP-2 and subsequent bone formation

et al. 2008

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Medical implants are increasingly often inserted into bone of frail patients, who are advanced in years. Due to age, severe trauma or pathology-related bone changes, osseous healing at the implant site is frequently limited. We were able to demonstrate that coating of endosseous implants with nanocrystalline diamond (NCD) allows stable functionalization by means of physisorption with BMP-2. Strong physisorption was shown to be directly related to the unique properties of NCD, and BMP-2 in its active form interacted strongest when NCD was oxygen-terminated. The binding of the protein was monitored under physiological conditions by single molecule force spectroscopy, and the respective adsorption energies were further substantiated by force-field-calculations. Implant surfaces refined in such a manner yielded enhanced osseointegration in vivo,when inserted into sheep calvaria. Our results further suggest that this technical advancement can be readily applied in clinical therapies with regard to bone healing, since primary human mesenchymal stromal cells strongly activated the expression of osteogenic markers when being cultivated on NCD physisorbed with physiological amounts of BMP-2.

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Section: Introductionmentioning

confidence: 99%

The role of oxygen termination of nanocrystalline diamond on immobilisation of BMP-2 and subsequent bone formation

et al. 2008

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“…54 In such a case, the overall texture of the implant can be maintained, while the cellular proliferation and differentiation were improved. 55 Immobilization of therapeutic agents that induce osteogenesis, eg, bisphosphonates and simvastatin, International Journal of Nanomedicine 2015:10 submit your manuscript | www.dovepress.com…”

Section: Dental Implant-bone Interfacementioning

confidence: 99%

Nanotechnology in dentistry: prevention, diagnosis, and therapy

Neel¹,

Bozec

Pérez³

et al. 2015

IJN

101

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Nanotechnology has rapidly expanded into all areas of science; it offers significant alternative ways to solve scientific and medical questions and problems. In dentistry, nanotechnology has been exploited in the development of restorative materials with some significant success. This review discusses nanointerfaces that could compromise the longevity of dental restorations, and how nanotechnolgy has been employed to modify them for providing long-term successful restorations. It also focuses on some challenging areas in dentistry, eg, oral biofilm and cancers, and how nanotechnology overcomes these challenges. The recent advances in nanodentistry and innovations in oral health-related diagnostic, preventive, and therapeutic methods required to maintain and obtain perfect oral health, have been discussed. The recent advances in nanotechnology could hold promise in bringing a paradigm shift in dental field. Although there are numerous complex therapies being developed to treat many diseases, their clinical use requires careful consideration of the expense of synthesis and implementation.

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“…These facts probably result in little research on diamond-based SAW sensors [5]. Extreme chemical stability and bio-inertness [16] make diamond ideal material for sensors operating in harsh or biologic environments.…”

Section: Introductionmentioning

confidence: 99%

“…The existing analysis approaches are based on the exact solution of the wave equation [4,[14][15][16]18].…”

Section: Introductionmentioning

confidence: 99%

Diamond in Surface Acoustic Wave Sensors

Hribsek¹,

Ristić²,

Radojković³

2010

Acta Phys. Pol. A

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The application of diamond in surface acoustic wave sensors is considered. The new method of the complete analyses of diamond-based gas chemical sensors is presented. It is based on the electromechanical equivalent circuit of the surface acoustic wave sensor. The method is very efficient and can be used for the optimal design of gas sensors. Since the diamond can be easily merged into solid state and biological systems, the development of smart biological sensors is possible. The advantages over silicon based sensors are also shown.

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Ordered growth of neurons on diamond

Cited by 145 publications

References 19 publications

The role of oxygen termination of nanocrystalline diamond on immobilisation of BMP-2 and subsequent bone formation

The role of oxygen termination of nanocrystalline diamond on immobilisation of BMP-2 and subsequent bone formation

Nanotechnology in dentistry: prevention, diagnosis, and therapy

Diamond in Surface Acoustic Wave Sensors

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