Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress

Ge, Jin‐Fang; Gao, Wen-Chao; Cheng, Wenming; Lu, Weili; Tang, Jie; Peng, Lei; Li, Ning; Chen, Feihu

doi:10.1016/j.euroneuro.2013.05.007

Cited by 58 publications

(35 citation statements)

References 53 publications

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“…Anxiety and depression often occur in combination, and a number of medications are found to be efficacious for both anxiety and depression (Levine et al, 2001). The findings of our study, together with a previous report (Ge et al, 2014), suggest that OG is a promising therapeutic candidate for psychological disorders of anxiety and depression.…”

Section: Discussionsupporting

confidence: 55%

“…One recent report provided evidence that OG was psychoactive against depression-like behaviors induced by chronic stress in the rat (Ge et al, 2014). In that study, OG reduced serum corticosterone levels and increased the hippocampal expression of brain-derived neurotrophic factor (BDNF).…”

Section: Discussionmentioning

confidence: 93%

“…Moreover, orcinol could affect the activity of rumen microbes in vitro (Murray et al, 1996). OG has antioxidative properties (Cichewicz & Nair, 2002;Wu et al, 2005), and was recently shown to have an antidepressant effect in rats (Ge et al, 2014). The anxiolytics of low-molecule natural phenols is the key focus of our research group (Liao et al, 2011;Wang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Anxiolytic effects of orcinol glucoside and orcinol monohydrate in mice

Wang

et al. 2014

Pharmaceutical Biology

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Context: Anxiety is a common psychological disorder, often occurring in combination with depression, but therapeutic drugs with high efficacy and safety are lacking. Orcinol glucoside (OG) was recently found to have an antidepressive action. Objective: To study the therapeutic potential of OG and orcinol monohydrate (OM) as anxiolytic agents. Materials and methods: Anxiolytic effects in mice were measured using the elevated plus-maze, hole-board, and open-field tests. Eight groups of mice were included in each test. Thirty minutes before each test, mice in each group received one oral administration of OG (5, 10, or 20 mg/kg), OM (2.5, 5, or 10 mg/kg), the positive control diazepam (1 or 5 mg/kg), or control vehicle. Each mouse underwent only one test. Uptake of orcinol (5 mg/kg) in the brain was qualitatively detected using the HPLC-MS method.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Anxiolytic effects of orcinol glucoside and orcinol monohydrate in mice

Wang

et al. 2014

Pharmaceutical Biology

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confidence: 99%

“…It has been reported that some of new antidepressants under development upregulate the expression of BDNF in different brain regions of stress mice via promoting the phosphorylation of ERK1/2 and AKT and thus activating the ERK, AKT pathways to produce antidepressant effects. [6][7][8] In recent studies, natural flavonoids especially resveratrol, tea polyphenols and curcumin show attractive prospect in the field of neural protection research.7,9,10) There is growing evidence indicated that flavonoids ameliorate the symptoms of depression via upregulating the levels of monoaminergic neurotransmitters 11) and promoting the expression of neurotrophic factors. 12,13) …”

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confidence: 99%

Antidepressant Activity of Astilbin: Involvement of Monoaminergic Neurotransmitters and BDNF Signal Pathway

Guo

et al. 2014

Biological & Pharmaceutical Bulletin

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Depression and related mood disorders are among the world's greatest public health problems. Previous studies have demonstrated that astilbin (AST) has broad pharmacological functions which may modulate numerous pathways, such as antioxidant, scavenging free radicals, anti-inflammatory and so on, similarly to some of other flavonoids. In this study, the antidepressant-like effect of AST was investigated using chronic unpredictable mild stress ( Key words depression; astilbin; chronic unpredictable mild stress; serotonin; dopamine; brain-derived neurotrophic factor Depression is a serious medical illness that characterized by affective disorder. According to the World Health Organization (WHO), by the year 2030, depression will result in more years of life lost to disability than any other illness.1) At present, most antidepressants used clinically with low efficacy and many side effects can not meet the clinical needs. Therefore, with the increased prevalence of depression and social burden every year, the development of new antidepressants is becoming a top priority.Despite the fact that the molecular and cellular mechanisms remain unclear, a leading hypothesis of depression recently suggests that neurotrophic factors and adult neurogenesis play critical roles in mediating the behavioural responses to antidepressants.2) The brain-derived neurotrophic factor (BDNF) is closely related to neuronal survival and neurogenesis and plays an important role in animal models of depression. Various stress procedures including chronic unpredictable mild stress (CUMS) result in obviously decreases of BDNF expression in the brain, while chronic administration of almost all kinds of antidepressants including imipramine regulates BDNF levels. [3][4][5] The extracellular signal-regulated kinases (ERK) and AKT pathways are the two important downstream signaling pathways of BDNF. It has been reported that some of new antidepressants under development upregulate the expression of BDNF in different brain regions of stress mice via promoting the phosphorylation of ERK1/2 and AKT and thus activating the ERK, AKT pathways to produce antidepressant effects. [6][7][8] In recent studies, natural flavonoids especially resveratrol, tea polyphenols and curcumin show attractive prospect in the field of neural protection research.7,9,10) There is growing evidence indicated that flavonoids ameliorate the symptoms of depression via upregulating the levels of monoaminergic neurotransmitters 11) and promoting the expression of neurotrophic factors. 12,13)

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Orcinol glucoside improves the depressive‐like behaviors of perimenopausal depression mice through modulating activity of hypothalamic–pituitary–adrenal/ovary axis and activating BDNF‐ TrkB‐CREB signaling pathway

Zhang

et al. 2021

Phytotherapy Research

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Orcinol Glucoside (OG), a phenolic glucoside isolated from C. orchioides, showed the antidepressant-like effect on chronic unpredictable mild stress (CUMS)-induced rats previously. This study was designed to determine whether OG could improve the depressive-like symptoms of perimenopausal depression (PMD) and the possible mechanisms involved. This research was performed on a PMD mice model established by a two-steps method of ovariectomy (OVX) followed CUMS. OG treatment effectively improved the depressive-like behaviors of OVX-CUMS mice, as indicated by increased sucrose intake in sucrose preference test (SPT), reduced immobility time in forced swimming test (FST), and tail suspension test (TST), lower frequency of grooming and defecation, increased actions of rearing, and prolonged duration in the center in open field test (OFT). OG treatment alleviated the OVX-CUMS induced dysfunction of hypothalamic-pituitary-ovarian (HPO) axis by increased serum estradiol (E2) and decreased ovarian hormones follicle stimulating hormone (FSH), luteinizing hormone (LH), and gonadotropin-releasing hormone (GnRH) in serum. Meanwhile, OG reversed the hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis as evidenced by decreased CORT and ACTH in serum, reduced as well as the mRNA and protein expression of corticotropin-releasing hormone (CRH) in hypothalamus and hippocampus. Moreover, OG up-regulated the protein expression of BDNF, TrkB, and phosphorylation level of CREB and ERK1/2 in hippocampus. These findings demonstrated that OG improves depressive behaviors of OVX-CUMS mice by modulating of HPO/HPA axis dysfunction, and activating BDNF-TrkB-CREB signaling pathway.

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Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress

Cited by 58 publications

References 53 publications

Anxiolytic effects of orcinol glucoside and orcinol monohydrate in mice

Anxiolytic effects of orcinol glucoside and orcinol monohydrate in mice

Antidepressant Activity of Astilbin: Involvement of Monoaminergic Neurotransmitters and BDNF Signal Pathway

Orcinol glucoside improves the depressive‐like behaviors of perimenopausal depression mice through modulating activity of hypothalamic–pituitary–adrenal/ovary axis and activating BDNF‐ TrkB‐CREB signaling pathway

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