Orchidaceae-Derived Anticancer Agents: A Review

Abstract

Species of orchids, which belong to the largest family of flowering plants, are commonly used in folk medicine for the treatment of infections and tumors. However, little is known about the actual chemical composition of these plants and their anticancer properties. In this paper, the most recent literature on orchid-derived bioactive substances with anticancer properties is reviewed. For the assessment, previous papers on the anticancer activity of Orchidaceae published since 2015 were considered. The papers were found by exploring electronic databases. According to the available data, many species of orchids contain potential antitumor chemicals. The bioactive substances in a relatively insignificant number of orchids are identified, and most studies are on Asian taxa. Broader research on American and African species and the correct identification of samples included in the experiments are essential for evaluating the usefulness of orchids as a plant family with vast anticancer potential.

New Phenolic Glycosides from Coelogyne fuscescens Lindl. var. brunnea and Their Cytotoxicity against Human Breast Cancer Cells

“…3 The Orchidaceae family is renowned in traditional medicine, particularly in treating infections and tumors. 4 However, despite their traditional medicinal uses, there is limited information about their specific chemical composition. Thus, further exploration and investigation of orchids are warranted for the identification of bioactive compounds present in these plants and to assess their potential as sources of novel anticancer agents.…”

“…However, despite their traditional medicinal uses, there is limited information about their specific chemical composition. Thus, further exploration and investigation of orchids are warranted for the identification of bioactive compounds present in these plants and to assess their potential as sources of novel anticancer agents. , In line with our ongoing research on anticancer compounds from orchids, , we turned our focus on the Coelogyne fuscescens Lindl. var.…”

“…The Orchidaceae family is renowned in traditional medicine, particularly in treating infections and tumors . However, despite their traditional medicinal uses, there is limited information about their specific chemical composition.…”

Cymensifin A: a promising pharmaceutical candidate to defeat lung cancer via cellular reactive oxygen species-mediated apoptosis

“…Various natural compounds have therapeutic potentials and low adverse effects on human health, and so are of interest in anticancer research ( Nobili et al, 2009 ; Śliwiński et al, 2022 ). Several orchid species of the Orchidaceae family are among the promising sources to search for anticancer agents and have been shown for their cytotoxicity against different malignant cells, including those derived from human lung cancers ( Jimoh et al, 2022a ; Jimoh et al, 2022b ; Śliwiński et al, 2022 ).…”

Analysis of metabolites and metabolism-mediated biological activity assessment of ginsenosides on microfluidic co-culture system

“…Malignant tumors are severe threats to human health and a major cause of death worldwide (Zhang et al, 2021). In 2020, 19.3 million malignant tumor cases and nearly 10 million malignant tumor deaths were reported worldwide, with 11.7% of female breast cancer, 11.4% of lung cancer, and 10.0% of colorectal cancer being the most common (Sliwinski et al, 2022). In spite of numerous clinical studies, the benefits of chemotherapeutic agents for the treatment of OPEN ACCESS EDITED BY cancer are unclear.…”