Orchestration Requirements for Modular Process Plants in Chemical and Pharmaceutical Industries

Klose, Anselm; Merkelbach, Silke; Menschner, Anna; Hensel, Stephan; Heinze, Sebastian; Bittorf, Lukas; Kockmann, Norbert; Schäfer, Christian; Szmais, Stefanie; Eckert, Manfred; Rüde, Timo; Scherwietes, Thomas; Santos, Polyana da Silva; Stenger, Frank; Holm, Thomas; Welscher, Wolfgang; Krink, Niclas; Schenk, T.C.W.; Stutz, Andreas; Maurmaier, Mathias; Stärk, Katharina D.C.; Hoernicke, Mario; Unland, Stefan; Erben, Stefan; Kessler, Franziska; Apitz, Frank; Urbas, Leon

doi:10.1002/ceat.201900298

Cited by 37 publications

(20 citation statements)

References 5 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The first unit consists of the feed and pump unit (FPU), the second is the ultrasonic unit (USU) and the third unit is the product analysis unit (PAU). In keeping with the modular concept, this structure would consist of three Process Equipment Assemblies (PEAs), which could be used as a single module [75].…”

Section: Experimental Set-upmentioning

confidence: 99%

Nucleation in continuous flow cooling sonocrystallization for coiled capillary crystallizers

2021

Self Cite

View full text Add to dashboard Cite

Nucleation in continuously operated capillary coiled cooling crystallizers is experimentally investigated under the influence of ultrasound. It was found that there is no sharp boundary but rather a transition zone for nucleation under sonication. For this purpose, a tube with an inner diameter of 1.6 mm and a length of 6 m was winded in a coiled flow inverter (CFI) design and immersed into a cooled ultrasonic bath (37 kHz). The CFI design was chosen for improved radial mixing and narrow residence time distribution, which is also investigated. Amino acid l-alanine dissolved in deionized water is employed in a supersaturation range of 1.10 to 1.46 under quiet and sonicated conditions. Nucleation is non-invasive detected using a flow cell equipped with a microscope and camera. Graphical abstract Since the interest and demand for small-scale, continuous crystallization increases, seed crystals were generated in a coiled tube via sonication and optically investigated and characterized. No distinct threshold for nucleation could be determined in a wide range of supersaturations of l-alanine in water

show abstract

Section: Experimental Set-upmentioning

confidence: 99%

Nucleation in continuous flow cooling sonocrystallization for coiled capillary crystallizers

2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…The main components of the FPU are two storage tanks, one containing solvent (water) and the other the feed, thus defined suspension or saturated solution (see Appendix A). For The whole plant consists of four units (see Figure 2), which would correspond to four Functional Equipment Assemblies (FEAs) according to the modular concept [85]. The first (PFU) includes the feed tanks and the process pump; the second (USU) is a seed crystal unit, where a CFI-designed coiled tube is immersed in an ultrasonic bath.…”

Section: Design Setup and Process Parametersmentioning

confidence: 99%

Continuous Cooling Crystallization in a Coiled Flow Inverter Crystallizer Technology—Design, Characterization, and Hurdles

et al. 2021

Self Cite

View full text Add to dashboard Cite

Continuous small-scale production is currently of utmost interest for fine chemicals and pharmaceuticals. For this purpose, equipment and process concepts in consideration of the hurdles for solids handling are required to transfer conventional batch processing to continuous operation. Based on empirical equations, pressure loss constraints, and an expandable modular system, a coiled flow inverter (CFI) crystallizer with an inner diameter of 1.6 mm was designed. It was characterized concerning its residence time behavior, tested for operation with seed crystals or an ultrasonic seed crystal unit, and evaluated for different purging mechanisms for stable operation. The residence time behavior in the CFI corresponds to ideal plug flow behavior. Crystal growth using seed crystals was demonstrated in the CFI for two amino acids. For fewer seed crystals, higher crystal growth rates were determined, while at the same time, secondary nucleation was observed. Feasibility for the interconnection of a sonicated seeding crystal unit could be shown. However, the hurdles are also identified and discussed. Prophylactic flushing combined with a photosensor for distinguishing between solvent and suspension phase can lead to stable and resource-efficient operation. The small-scale CFI technology was investigated in detail, and the limits and opportunities of the technology are presented here.

show abstract

“…Die Erfolge in einer Pharmaindustrie 4.0 sind jedoch nicht nur auf das durch Bits und Bytes Mögliche begrenzt, sondern werden von Menschen gemacht. Chemie‐ und Bioverfahrensingenieurinnen und ‐ingenieure sind in der Verwirklichung unserer Vorstellung von Gesundheit und Lebensqualität ein wichtiges Bindeglied zwischen dem Verständnis molekularer Vorgänge in biologischen Systemen, der Entwicklung von Verfahren und analytischen Methoden sowie der Planung, dem Bau und dem Betrieb moderner Produktionsanlagen 21–29.…”

Section: Die Pharmazeutische Industrie Ist Im Wandelunclassified

Schluss mit Kompetenzen! Praxisnahe Bildung für die Pharmaindustrie 4.0

Daubenfeld

Geis²,

Gros

2021

Chemie Ingenieur Technik

View full text Add to dashboard Cite

Die gegenwärtigen Veränderungen in der pharmazeutischen Industrie wirken sich auch auf die Anforderungsprofile von Hochschulabsolventinnen und ‐absolventen aus. In diesem Beitrag beschreiben die Autoren ihre Erfahrungen mit und Einsichten zu diesem Thema aus Sicht einer Hochschule für Angewandte Wissenschaften und aus Sicht der Industrie. Bewusst provozierend hinterfragen sie die starke Betonung der Kompetenzorientierung und deren gegenwärtige Umsetzung in der Hochschullehre. Sie meinen, dass die Beschreibung von Modulen und Lernzielen dem für die Praxis unabdingbaren Fachwissen häufig zu wenig Raum gibt und stellen den Zweiklang aus Wissen und Können am Beispiel der Lehrphilosophie von Carl Remigius Fresenius (1818–1897) als Gegenpol dar. Am Beispiel der M.Sc. Executive Initiative wird die Notwendigkeit und konkrete Umsetzbarkeit der Verflechtung von Wissensvermittlung und anwendungsorientierter Lehre im Kontext der Pharmaindustrie 4.0 verdeutlicht.

show abstract

Orchestration Requirements for Modular Process Plants in Chemical and Pharmaceutical Industries

Cited by 37 publications

References 5 publications

Nucleation in continuous flow cooling sonocrystallization for coiled capillary crystallizers

Nucleation in continuous flow cooling sonocrystallization for coiled capillary crystallizers

Continuous Cooling Crystallization in a Coiled Flow Inverter Crystallizer Technology—Design, Characterization, and Hurdles

Schluss mit Kompetenzen! Praxisnahe Bildung für die Pharmaindustrie 4.0

Contact Info

Product

Resources

About