Orbiviruses of the Kemerovo complex and neurological diseases

Libíková, H; Heinz, Franz X.; Ujházyová, D; Stünzner, D

doi:10.1007/bf02121159

Cited by 41 publications

(11 citation statements)

References 4 publications

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“…The genus Orbivirus is the largest of 15 genera within the family Reoviridae , currently containing 22 recognized virus species [ 1 ]. Several species are known to cause serious disease in animals, and orbivirus infections have also been documented in association with human disease [ 2 ]. The orbiviruses are vector-borne, primarily transmitted by ticks or hematophagus insect-vectors (including Culicoides , mosquitoes and sand flies), and have a wide host-range that collectively includes domestic and wild ruminants, equines, marsupials, sloths, bats, birds and humans [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Isolation of Tibet orbivirus, TIBOV, from Culicoides Collected in Yunnan, China

Lei

Guo

et al. 2015

PLoS ONE

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We isolated a novel virus strain (YN12246) from Culicoides spp. specimens collected at the China-Laos-Myanmar border in southern Yunnan Province. This virus had a cytopathic effect (CPE) on both insect cells (C6/36) and mammalian cells (BHK-21). Electron microscopy revealed the structure of the virions to be spherical with a diameter of 75 nm. Polyacrylamide gel analysis demonstrated that the viral genome consisted of 10 segments of double-stranded RNA (dsRNA), with a distribution pattern of 3-3-3-1. The coding sequences of 9 genome segments of YN12246 (Seg1, Seg3-Seg10) were obtained by high-throughput sequencing and Sanger sequencing. Comparisons of conserved genome segments 1 and 3 (Seg1 and Seg3), encoding the polymerase-VP1 and sub-core T2 protein, respectively, showed that YN12246 groups with the Culicoides-borne orbiviruses. The highest levels of sequence identity were detected between YN12246 and Tibet orbivirus (TIBOV), indicating that they belong to the same virus species (with amino acid identity of 98.8% and 96.4% for the polymerase and T2 protein, respectively). The data presented here confirm that YN12246 is a member of the TIBOV species, which was first isolated from mosquitoes in 2009. This is the first report of the isolation of TIBOV from Culicoides.

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Section: Introductionmentioning

confidence: 99%

Isolation of Tibet orbivirus, TIBOV, from Culicoides Collected in Yunnan, China

Lei

Guo

et al. 2015

PLoS ONE

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“…Kemerovo virus (KEMV) was isolated from I. persulcatus female ticks collected in the Kemerovo region (Russia) (Libikova et al 1970 ). Neutralizing antibodies to KEMV were found in sera from humans, livestock, wild rodents, and birds (Libikova et al 1970 , 1978 ). Another two members of the GIV group, Lipovnik virus (LIPV) and Tribec virus (TRBV), which are quite closely related to KEMV, were isolated from adult I. ricinus ticks collected in Czechoslovakia in 1963 (Libikova et al 1964 ).…”

Section: Families Unassigned To Any Ordermentioning

confidence: 99%

Tick-Borne Viruses

et al. 2018

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Ticks are important vectors for the transmission of pathogens including viruses. The viruses carried by ticks also known as tick-borne viruses (TBVs), contain a large group of viruses with diverse genetic properties and are concluded in two orders, nine families, and at least 12 genera. Some members of the TBVs are notorious agents causing severe diseases with high mortality rates in humans and livestock, while some others may pose risks to public health that are still unclear to us. Herein, we review the current knowledge of TBVs with emphases on the history of virus isolation and identification, tick vectors, and potential pathogenicity to humans and animals, including assigned species as well as the recently discovered and unassigned species. All these will promote our understanding of the diversity of TBVs, and will facilitate the further investigation of TBVs in association with both ticks and vertebrate hosts.

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“…In current taxonomy, the genus Orbivirus, family Reoviridae, comprises 21 species; 11 additional "tentative species" are recognized by the International Committee on Taxonomy of Viruses (ICTV) (8,9). Species have high sequence similarity and potential for segmental reassortment.…”

mentioning

confidence: 99%