Orbitofrontal cortex grey matter volume is related to children’s depressive symptoms

Vandermeer, Matthew R. J.; Liu, Pan; Ali, Ola Mohamed; Daoust, Andrew R.; Joanisse, Marc F.; Deanna, M; Hayden, Elizabeth P.

doi:10.1016/j.nicl.2020.102395

Cited by 8 publications

(5 citation statements)

References 127 publications

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“…Although our findings are generally consistent with the previous literature showing significantly reduced frontal, parietal, temporal, orbito-frontal cortex volumes [8,22], our results of amygdala, striatum, and hippocampus volumes in MDD patients are partly inconsistent with the previous literature [10,34–36]. Here, we found, unexpectedly, that striatal and amygdala volumes were significantly increased in the MDD group when compared to the control group while hippocampal volumes were unchanged.…”

Section: Discussionsupporting

confidence: 78%

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Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method

2021

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Background Quantitative analysis of the highresolution T1-weighted images provides useful markers to measure anatomical changes during brain degeneration related to major depressive disorder (MDD). However, there are controversial findings regarding these volume alterations in MDD indicating even to increased volumes in some specific regions in MDD patients. MethodsThis study is a case-controlled study including 23 depression patients and 15 healthy subject person and 20-38 years of age, who have been treated at the Neurology and Psychiatry Department here. We compared specific anatomic regions between drug-free MDD patients and control group through MRI-Cloud, which is a novel brain imaging method that enables to analyze multiple brain regions simultaneously. ResultsWe have found that frontal, temporal, and parietal hemispheric volumes and middle frontal gyrus, inferior frontal gyrus, superior parietal gyrus, cingulumhippocampus, lateral fronto-orbital gyrus, superior temporal gyrus, superior temporal white matter, middle temporal gyrus subanatomic regions were significantly reduced bilaterally in MDD patients compared to the control group, while striatum, amygdala, putamen, and nucleus accumbens bilaterally increased in MDD group compared to the control group suggesting that besides the heterogeneity among studies, also comorbid factors such as anxiety and different personal traits could be responsible for these discrepant results. ConclusionOur study gives a strong message that depression is associated with altered structural brain volumes, especially, in drug-free and first-episode MDD patients who present with similar duration and severity of depression while the role of demographic and comorbid risk factors should not be neglected.

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Section: Discussionsupporting

confidence: 78%

“…Herewith, there are several studies demonstrating significant alterations in brain volumes in MDD patients. Overall, these studies have indicated that hippocampus, insula, prefrontal, and orbitofrontal cortex are among the most affected regions during the course of depression [6–9].…”

Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method

2021

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“…For an 11-year-long follow-up study, this retention rate is better than expected (Teague et al, 2018 ). Chi-square and t-tests were used to compare the current subsample to members of original sample who did not participate in this follow-up study; the groups did not significantly different when compared on caregiver or youth age, socioeconomic status, ethnicity, maternal lifetime history of anxious or depressive disorders (assessed via clinical interview; see Vandermeer et al, 2020 , for more details), or youths’ depressive or anxious symptoms at age 11 (i.e., the most proximal previous assessment wave available; all ps > 0.05). Data were collected using Qualtrics XM (Qualtrics, USA), with separate individual survey links sent by email to parents and youths to allow for independent self-report.…”

Section: Methodsmentioning

confidence: 99%

Development and Preliminary Validation of the Pandemic Avoidance and Concern Scales (PACS)

Daoust

Stanton

Vandermeer

et al. 2022

J Psychopathol Behav Assess

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The COVID-19 pandemic has led to radical disruptions to the routines of individuals and families, but there are few psychometrically assessed measures for indexing behavioural responses associated with a modern pandemic. Given the likelihood of future pandemics, valid tools for assessing pandemic-related behavioral responses relevant to mental health are needed. This need may be especially salient for studies involving families, as they may experience higher levels of stress and maladjustment related to school and business closures. We therefore created the Pandemic Avoidance and Concern Scales (PACS) to assess caregivers’ and youths’ adjustment to COVID-19 and future pandemics. Concern and Avoidance factors derived from exploratory factor analyses were associated with measures of internalizing symptoms, as well as other indices of pandemic-related disruption. Findings suggest that the PACS is a valid tool for assessing pandemic-related beliefs and behaviors in adults and adolescents. Preliminary findings related to differential adjustment between caregivers and youths are discussed.

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“…Data for this study were collected from children and their mothers across four separate assessment visits (for more details see Vandermeer et al, 2020). Briefly, this included: 1) a phone interview to complete the parent-report portion of the Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime Version (K-SADS-PL; Kaufman et al, 1997); 2) a home visit to complete the child self-report portion of the K-SADS-PL, gather MFC audio stimuli, and complete questionnaire measures; 3) a lab visit to complete the SCID-I/NP with moms and the Trier Social Stress Task for Children (Buske-Kirschbaum et al, 1997) with child participants (not discussed in this paper); 4) a MRI visit.…”

Section: Procedures and Measuresmentioning

confidence: 99%

Children’s neural reactivity to maternal praise and criticism: Associations with early depressive symptoms and maternal depression

Vandermeer

Liu²,

Ali³

et al. 2022

Dev Psychopathol

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Caregiving experiences are implicated in children’s depression risk; however, children’s neural reactivity to positive and negative feedback from mothers, a potential mediator of depression risk, is poorly understood. In a sample of 81 children (Mage = 11.12 years, SDage = 0.63), some of whom were recruited based on a maternal history of depression (n = 29), we used fMRI to characterize children’s neural responses to maternal praise and criticism. Maternal history of depression was unrelated to children’s brain activity during both the praise and criticism conditions; however, ROI analyses showed that children’s self-reported depressive symptoms were negatively associated with functional activity in the left anterior insula and right putamen while hearing maternal criticism. Whole-brain analyses showed that children’s depressive symptoms were positively associated with left inferior frontal gyrus activity while listening to maternal praise. These findings complement past work implicating these brain regions in the processing of emotionally salient stimuli, reward processing, and internal speech. Given associations between early depressive symptoms and later disorder, findings suggest that maladaptive neural processing of maternal feedback may contribute to children’s early emerging risk for depression.

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Orbitofrontal cortex grey matter volume is related to children’s depressive symptoms

Cited by 8 publications

References 127 publications

Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method

Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method

Development and Preliminary Validation of the Pandemic Avoidance and Concern Scales (PACS)

Children’s neural reactivity to maternal praise and criticism: Associations with early depressive symptoms and maternal depression

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