Orbito-scleral-sinus invasion of basal cell carcinoma in an immunocompromised patient on vismodegib

Tran, Ann Q; Patete, Carissa L.; Blessing, Nathan W.; Rong, Andrew J.; Garcia, Armando L; Dubovy, Sander R.; Tse, David T.

doi:10.1080/01676830.2020.1753783

Cited by 8 publications

(8 citation statements)

References 12 publications

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“…Declining surgical treatment can cause irreversible damage, especially in elderly patients with poor compliance [5][6][7][8][9][10]. Increased risk of mental diseases, including dementia and schizophrenia with advanced age, can diminish the patient's compliance [5,6,8,9].…”

Section: Discussionmentioning

confidence: 99%

Clinical time course of the neglected giant sebaceous gland carcinoma

Mangan¹,

Ozcan²,

Aksoy³

2021

rjo

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In this report, we discussed the progression from the initial presentation until surgical intervention, clinical course, and devastating outcome of a neglected giant sebaceous gland carcinoma of the eyelid in a poorly compliant elderly patient. A 79-year-old woman was referred for treatment of a giant ulcero-nodular lesion in the right upper eyelid. Nine months before, an orange lesion arising from the tarsal conjunctiva in the upper eyelid was observed in her examination undergone in the healthcare center where she initially presented, and the cornea appeared transparent. Surgical excision was recommended, which she declined. The examination three months before in the same center revealed that the lesion invaded the globe and anterior segment architecture could not be visualized. She was then recommended surgical removal of the eyeball, which she also refused. Radiological imaging demonstrated a 33x35 mm mass lesion in the superior lateral of orbit with exophytic growth and invasion of the globe and no systemic metastases were found. Total orbital exenteration surgery was immediately planned and performed. Histopathological examination revealed sebaceous gland carcinoma. Elderly patients with poor compliance should discuss their condition with a psychiatrist and should be managed by a multidisciplinary approach. This way, patients with eyelid malignancies can be encouraged to undergo surgery and receive early treatment, decreasing the need for exenteration, improving clinical outcomes, and reducing the risk of morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Clinical time course of the neglected giant sebaceous gland carcinoma

Mangan¹,

Ozcan²,

Aksoy³

2021

rjo

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“…Reports on SHH inhibitors in immunosuppressed patients with locally advanced or metastasizing BCC are rare [11]. Effectual use of a SHH inhibitor in combination…”

Section: Clinical Lettermentioning

confidence: 99%

Sonidegib in a patient with multiple basal cell carcinomas and HIV infection

Hoffmann

Husak²,

Maiwirth³

et al. 2021

J Deutsche Derma Gesell

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“…The article reports good tolerance and no interactions between Vismodegib and the previous cART ( 132 ). Reports on SHH inhibitors in immunocompromised patients witch locally advanced or metastasizing BCC are rare ( 133 ). Effectual use of Vismodegib and the lack of drug to drug interaction with cART (tenofovir/emtricitabine/rilpivirine) has been described in a single case ( 132 ).…”

Section: From Prevention To Therapymentioning

confidence: 99%

Non-Melanoma Skin Cancer in People Living With HIV: From Epidemiology to Clinical Management

Rullo

Maimone

Fiorica³

et al. 2021

Front. Oncol.

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Skin cancers represent the most common human tumors with a worldwide increasing incidence. They can be divided into melanoma and non-melanoma skin cancers (NMSCs). NMSCs include mainly squamous cell (SCC) and basal cell carcinoma (BCC) with the latest representing the 80% of the diagnosed NMSCs. The pathogenesis of NMSCs is clearly multifactorial. A growing body of literature underlies a crucial correlation between skin cancer, chronic inflammation and immunodeficiency. Intensity and duration of immunodeficiency plays an important role. In immunocompromised patients the incidence of more malignant forms or the development of multiple tumors seems to be higher than among immunocompetent patients. With regards to people living with HIV (PLWH), since the advent of combined antiretroviral therapy (cART), the incidence of non-AIDS-defining cancers (NADCs), such as NMSCs, have been increasing and now these neoplasms represent a leading cause of illness in this particular population. PLWH with NMSCs tend to be younger, to have a higher risk of local recurrence and to have an overall poorer outcome. NMSCs show an indolent clinical course if diagnosed and treated in an early stage. BCC rarely metastasizes, while SCC presents a 4% annual incidence of metastasis. Nevertheless, metastatic forms lead to poor patient outcome. NMSCs are often treated with full thickness treatments (surgical excision, Mohs micro-graphic surgery and radiotherapy) or superficial ablative techniques (such as cryotherapy, electrodesiccation and curettage). Advances in genetic landscape understanding of NMSCs have favored the establishment of novel therapeutic strategies. Concerning the therapeutic evaluation of PLWH, it’s mandatory to evaluate the risk of interactions between cART and other treatments, particularly antiblastic chemotherapy, targeted therapy and immunotherapy. Development of further treatment options for NMSCs in PLWH seems needed. We reviewed the literature after searching for clinical trials, case series, clinical cases and available databases in Embase and Pubmed. We review the incidence of NMSCs among PLWH, focusing our attention on any differences in clinicopathological features of BCC and SCC between PLWH and HIV negative persons, as well as on any differences in efficacy and safety of treatments and response to immunomodulators and finally on any differences in rates of metastatic disease and outcomes.

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Orbito-scleral-sinus invasion of basal cell carcinoma in an immunocompromised patient on vismodegib

Cited by 8 publications

References 12 publications

Clinical time course of the neglected giant sebaceous gland carcinoma

Clinical time course of the neglected giant sebaceous gland carcinoma

Sonidegib in a patient with multiple basal cell carcinomas and HIV infection

Non-Melanoma Skin Cancer in People Living With HIV: From Epidemiology to Clinical Management

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