Orbital Tumors

Dutton, Jonathan J.; Sines, Daniel T.; Elner, Victor M.

doi:10.1007/978-1-4614-0971-7_57

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2014

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“…5,6 SFT displays a more irregular architecture compared to fascicular arrangement of spindle cells found in this tumor. 7,8 Although SFT and spindle cell lipoma may display the focal desmin positivity found in this case, focal desmin positivity also occurs in MFB. 3 Each of these three tumors may arise from a CD34positive perivascular stem cell possessing the capacity for lipocytic, fibroblastic, and myofibroblastic differentiation.…”

Section: Commentmentioning

confidence: 79%

Orbital and Intraocular Myofibroblastoma

Costin

Plesec

Rubinstein

et al. 2014

Orbit

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A 66-year-old woman presented with a blind, painful, hypertensive, and proptotic left eye. Computed tomographic imaging revealed a well-circumscribed mass involving the left orbit and globe. Metastatic work-up failed to reveal extraorbital lesions and the tumor was removed in toto via an evisceration approach orbitotomy. Histopathology and immunohistochemistry were most consistent with mammary-type myofibroblastoma with fascicles of bland, uniform spindle cells that stained positive for desmin and CD34. We are not aware of previous reports of orbital or ocular myofibroblastoma. This neoplasm has not been shown to recur, undergo malignant transformation, or metastasize. Familiarity with its clinical, histopathologic, and immunohistochemical features may improve diagnostic accuracy and treatment decisions for patients presenting with similar findings.

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Section: Commentmentioning

confidence: 79%