Orbital solitary fibrous tumor: A painless mass after a dacryochystorhinostomy

Araújo, Maria; Borges, Tânia; Mahia, Yolanda; Lages, Vânia; Pereira, Ana

doi:10.1016/j.sjopt.2018.12.004

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…4 cases had a previous history of DCR. [5][6][7][8] They may easily be misdiagnosed due to their rarity, heterogeneity of clinical presentations and histological appearances. 9 Definitive diagnosis can be made by histopathological and immunohistochemical examination only, due to the variability in radiological appearances.…”

Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumor of the lacrimal sac mimicking lacrimal sac mucocele: A case report with review of literature

K S,

Velu

2023

IJOOO

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Solitary fibrous tumors (SFT) are benign neoplasms, composed of spindle-shaped cells. It has been reported in numerous locations in the body, but SFT of lacrimal sac is very rare. A 67 year old man clinically diagnosed as lacrimal sac mucocoele. During DCR, there was a yellowish mass with vascularisation on the surface. The mass was removed in-toto. Histopathology and immune-histochemisty confirmed SFT of lacrimal sac. Patient was followed up for 6 months without any recurrence.

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Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumor of the lacrimal sac mimicking lacrimal sac mucocele: A case report with review of literature

K S,

Velu

2023

IJOOO

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“…Although Bcl-2 expression is extremely high in SFT, it is negative in most malignant mesotheliomas. In this view, integrating these two IHC markers would increase the diagnostic accuracy[ 11 , 12 ]. In the present study, the IHC staining pattern (CD34+, Bcl-2+) was consistent with most cases of orbital SFT in previous reports.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and prognosis of orbital solitary fibrous tumor in patients from a Chinese tertiary eye hospital

Ren¹,

Li²,

Wu³

et al. 2022

WJCC

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BACKGROUND Solitary fibrous tumor (SFT) is predominant within the pleura but very rare in the orbit, which is why the diagnosis of orbital SFT poses challenges in clinical practice. Accordingly, an integrated approach that incorporates specific clinical features, histological, histopathological, and immunohistochemical (IHC) examinations, and molecular analyses is warranted. AIM To retrospectively explore the clinical and imaging characteristics, treatment, outcomes of a series of patients with orbital SFT. METHODS We conducted a retrospective review of a series of patients diagnosed with a histopathologic orbital SFT treated at a single institution. All data on demogra/phics, clinical characteristics, imaging, treatment, postoperative histopathological and IHC examinations, and prognosis were collected. RESULTS In total, 13 patients were enrolled, 7 (53.8%) of whom had the tumor located in the superomedial quadrant of the orbit. Computed tomography revealed a solitary ovoid lesion in 10 (76.9%) patients and irregular lesion in 3 (23.1%) patients. Magnetic resonance imaging results were as follows: On T1 weighted images, 3 (23.1%) patients had hypointense mixed signals, whereas 10 (76.9%) patients showed isointense mixed signals; on T2 weighted images (T2WI), 3 (23.1%), 4 (30.8%), and 6 (46.2%) patients exhibited hypointense mixed, isointense mixed, and hyperintense signals, respectively. Notably, 12 (92.3%) patients showed significant enhancement, whereas there were patchy slightly enhanced areas in the tumor. All patients were treated by surgery. IHC analysis demonstrated that the tumor cells were immunoreactive for CD34, CD99, STAT-6, and vimentin in all patients. The lesions showed Ki-67 positivity < 5% in 1 (7.7) patient, 5%-10% in 10 (76.9%), and > 10% in 2 (15.4%). Two (15.4%) patients exhibited tumor recurrence. CONCLUSION The clinical manifestations and radiologic characteristics of orbital SFT are diverse and not specific. Accurate diagnosis and treatment require detailed radiological and histopathological/IHC evaluation.

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“…The typical SFT phenotype is that the tumor cells are spindle-shaped, and the alternately arranged sparse and dense cells are separated by eosinophilic collagen ber bands [9] . Normally, immunohistochemical markers are fundamental for the diagnosis, and the combination of immunohistochemical markers CD34 and Bcl-2 increase the diagnostic accuracy [10,11] . The expression of CD34 is usually diffuse and intense, but according to the report, the expression of Bcl-2 is very high in STF and negative in most malignant mesotheliomas.…”

Section: Histopathological and Immunohistochemical Features Of Orbitamentioning

confidence: 99%

The Diagnosis and Treatment of Orbital Solitary Fibrous Tumor

Ren

et al. 2020

Preprint

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BackgroundSolitary fibrous tumor (SFT) is an uncommon spindle-cell tumor of mesenchymal origin, it commonly occurs within pleura, the occurrence of SFT in the orbit is very rare. The diagnosis of orbital SFT is challenging in clinical, and requires an integrated approach that includes specific clinical, histological, immunohistochemical, and even molecular findings.MethodsIn our retrospective study, we collected 13 patients with orbital SFT. All patients were diagnosed with orbital SFT by postoperative histopathological and immunohistochemical examination. Patient charts and medical records were reviewed for demographic information, relevant medical and family history, clinical presentation, radiological examination, histopathological and immunohistochemical examination, the treatment and prognosis.ResultsThis study included 7 males and 6 females. The age ranged from 11 to 78 years. 7 patients presented with predominant features of exophthalmos. 7 patients showed eyeball dislocation. 6 patients with motility disturbances. 9 patients had the palpable masses. 6 patients had the secondary lesions. On CT scan, there were 6 patients were located in the superomedial quadrant of the orbit, 3 patients were located in the inferomedial quadrant of the orbit. The morphology of lesions was solitary ovoid mass in 10 patients, and irregular mass in 3 patients. The CT value of the tumor was 22.8-64.4Hu, with the median of 45.9Hu. On MRI, 3 patients showed hypointense mixed signals on T1WI, 10 patients showed isointense mixed signal on T1WI. 3 patients showed hypointense mixed signals, 4 patients showed isointense mixed signals, 6 patients showed hyperintense signals on T2WI. There were 12 patients showed obviously enhancement, and we found patchy lesions which were no enhancement in the tumor. All patients were treated by surgery. Immunohistochemical analysis showed that the tumor cells exhibited diffuse immunoreactivity for CD34 and CD99 in all the patients. The lesions were positive for Bcl-2 in 11 patients. The lesions were positivity for Ki-67 <5% in one patient, 5%-10% in 10 patients, >10% in 2 patients. ConclusionsThe lesions are often outside the muscular cone, most commonly located at superomedial quadrant and inferomeddial quadrant of the orbit. The density of the lesions is uneven in most cases, the mean CT values of the tumors on CT scans are variable. The signal of lesions on orbital MRI is uncertainty, it is inheterogeneous enhancement, and the lamellar unenhanced regions can also be found in the lesion. The complete gross resection, and even more aggressive wide excision is preferred. Although the Ki-67 labelling index is very low, malignant forms with an increased propensity for local recurrence have been found. A longer follow-up is needed to determine the recurrence rate of the disease, and to identify the causes of recurrence.

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Orbital solitary fibrous tumor: A painless mass after a dacryochystorhinostomy

Cited by 3 publications

References 12 publications

Solitary fibrous tumor of the lacrimal sac mimicking lacrimal sac mucocele: A case report with review of literature

Solitary fibrous tumor of the lacrimal sac mimicking lacrimal sac mucocele: A case report with review of literature

Clinical characteristics and prognosis of orbital solitary fibrous tumor in patients from a Chinese tertiary eye hospital

The Diagnosis and Treatment of Orbital Solitary Fibrous Tumor

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