Orbital Rhabdomyosarcoma in an Adult, Case Report

doi:10.20431/2455-572x.0301004

Cited by 1 publication

(5 citation statements)

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“…This study is premised on the finding that rhabdomyosarcoma in adults is associated with an unfavorable prognosis. 1,12 This claim was substantiated by the aggressive nature of the disease leading to the unfortunate demise of the patient, as documented in this case report.…”

Section: Theory Of the Studymentioning

confidence: 59%

“…Clinical features may mimic inflammatory conditions such as orbital cellulitis 13 . A case report in a 25 year old man was masked by ethmoidal sinusitis 12 . It presented as an orbital apex syndrome in a 12 year old boy 14 Rhabdomyosarcoma could cause an acute, rapidly progressive proptosis, globe displacement, blepharoptosis, conjunctival and eyelid swelling, palpable mass, diplopia, pain (rare) 3,12 .…”

Section: Discussionmentioning

confidence: 99%

“…A case report in a 25 year old man was masked by ethmoidal sinusitis 12 . It presented as an orbital apex syndrome in a 12 year old boy 14 Rhabdomyosarcoma could cause an acute, rapidly progressive proptosis, globe displacement, blepharoptosis, conjunctival and eyelid swelling, palpable mass, diplopia, pain (rare) 3,12 . The tumor location-most commonly superonasal or superiorly (25%) 3,9,12 .…”

Section: Discussionmentioning

confidence: 99%

“…Currently, 5 year overall survival (OS) of children exceeds 70% for non-metastatic RMS 3,[9][10] . RMS is rare in adults; very few adult cases are reported in literature and in contrast, the outcome of adult patients remains poor 12 . Various genetic predispositions have been identified, including variants of the RB1 gene responsible for retinoblastoma 10 .…”

Section: Discussionmentioning

confidence: 99%

“…It presented as an orbital apex syndrome in a 12 year old boy 14 Rhabdomyosarcoma could cause an acute, rapidly progressive proptosis, globe displacement, blepharoptosis, conjunctival and eyelid swelling, palpable mass, diplopia, pain (rare) 3,12 . The tumor location-most commonly superonasal or superiorly (25%) 3,9,12 . It may arise in the conjunctiva or uvea; intracranial extension of the tumor is usually by bony erosion through perforation on the medial side of the orbit or in the inferior orbital wall.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

A Case of Orbital Rhabdomyosarcoma with Intracranial Extension in an Adult: Diagnostic and Management Challenges

Ugboaku (MBBS),

Folusho (MD),

Aimebelomo

et al. 2023

AJHMN

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Purpose: To report a rare case of orbital rhabdomyosarcoma with intracranial extension in an adult and the challenges in managing this case. Methodology: Research design was through a case report, while data was collected through observation, analysis of medical records and individual interviews. Interpretation of data was through the qualitative method of data analysis. Findings: A 34-year-old female meat seller was referred to our center with a rapidly progressive protrusion of the right eye of one month duration. She had a previous history of a penetrating injury to the right globe with bone fragment retention. She had had evisceration. Two weeks post-surgery, she noticed pain and a progressively worsening swelling around the right orbit. In our center, an initial diagnosis of orbital cellulitis post-evisceration was entertained. Orbito-cranial CT scan and MRI done showed a large homogenous irregular soft tissue mass occupying the right orbital cavity with extension to the right lateral rectus, lacrimal gland, cavernous sinus, optic nerve and brain parenchyma; findings were suggestive of orbital rhabdomyosarcoma with intracranial extension. The patient was discharged against medical advice. She re-presented 7 weeks later with a much larger mass which had multiple friable bleeding sites. With much assurance by the oncologists, she had several blood transfusions and 6 courses of chemotherapy. Tumour regression was very impressive. Incisional biopsy and histology confirmed rhabdomyosarcoma with chemotherapeutic changes. The patient was stable and so referred to another tertiary center for External Beam Radiation Therapy (EBRT), but this was delayed due to financial constraints. Two months from her referral for EBRT, colleagues reported she died of intractable seizures Recommendations: This study is based on suggestions that therapeutic success for rhabdomyosarcoma is better in children with survival rates reaching 75% unlike in adults where prognosis is poor.1 In this report, remission was observed soon after commencement of treatment. Therefore, it is recommended that early diagnosis be done to improve outcomes. Secondly, combination drugs should be used in all rhabdomyosarcoma cases. Lastly, government policies geared towards universal health coverage should be made and implemented.

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Section: Theory Of the Studymentioning

confidence: 59%