Orbital pseudotumor and Crohn disease

Camfield, Peter; White, M.; Warner, H. A.; Lythgoe, Colin

doi:10.1016/s0022-3476(82)80214-x

Cited by 18 publications

(6 citation statements)

References 2 publications

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“…Case reports: we retrieved 23 case reports/case series including 24 children with O-EIMs (table 3). Reported conditions included: central retinal vein/artery occlusion, [30][31][32] orbital myositis/orbital pseudotumor, [33][34][35][36][37][38][39] choroidal neovascular membrane, 40 nasolacrimal duct obstruction, 41 dacryoadenitis, 42 dry eyes syndrome, 43 cataract, 43 unilateral/bilateral uveitis, [44][45][46] episcleritis, 47 keratopathy/keratitis, 48,49 granulomatous conjunctivitis, 50 optic neuritis, 51 and recurrent neuroretinitis. 52 All patients presented with ocular symptoms when evaluated, including reduced visual acuity (even sudden vision loss), ocular pain/discomfort, redness, eyelid swelling, proptosis, photophobia, and diplopia.…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Ocular Manifestations of Paediatric Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Ottaviano

Salvatore

Salvatoni

et al. 2018

Journal of Crohn's and Colitis

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Data on O-EIMs in children are scarce. Prevalence of O-EIMs is lower than in adults but may be underestimated because of the possibility of asymptomatic uveitis; however, the long-term significance of this condition is unknown. Children with CD may be at increased risk of O-EIMs. No recommendations on routine ophthalmological examination can be made, but a low threshold for ophthalmological referral should be maintained. Larger studies in paediatric IBD populations are needed.

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Section: A N U S C R I P Tmentioning

confidence: 99%

Ocular Manifestations of Paediatric Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Ottaviano

Salvatore

Salvatoni

et al. 2018

Journal of Crohn's and Colitis

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“…Three cases of 'orbital pseudotumour' associated with CD have been published. Patients in those cases were all in their early teens and had ileal CD (6)(7)(8). We report a case in which the ocular symptoms and findings brought the patient to medical attention.…”

Section: Discussionmentioning

confidence: 97%

Keeping an Eye on Crohn’s Disease: Orbital Myositis as the Presenting Symptom

Durno¹,

Ehrlich²,

Taylor³

et al. 1997

Canadian Journal of Gastroenterology

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Episodic periorbital swelling due to presumed orbital inflammation and myositis caused intermittent apparent proptosis and was the presenting symptom of ileocecal Crohn's disease (CD) in a teenage female with a family history of autoimmune disorders and CD. Orbital myositis, a very rare extraintestinal manifestation of inflammatory bowel disease (IBD), likely represents a process of impaired immunoregulation related to the underlying intestinal inflammation. This rare manifestation of IBD simulates the more commonly encountered thyroid orbitopathy (ophthalmopathy), but IBD should be considered if all thyroid tests are negative. It is important to recognize that orbital myositis may be an extraintestinal manifestation of Crohn's disease so that the diagnosis can be made and appropriate therapy commenced.

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“…A population-based study has shown that ocular involvement occurs in 1-2% of patients with IBD [167], with the prevalence of orbital manifestations being presumably lower. Less than 25 cases of IBD associated with orbital inflammation and/or orbital myositis have been reported in the literature [9,[168][169][170][171][172][173][174][175][176][177][178][179][180][181][182][183][184][185].…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

“…With regard to treatment, corticosteroids are the mainstay for induction, with some reports employing initial IV pulse dosing (usually 1 mg/kg/day) followed by oral taper and other reports employing only oral dosing, both of which had mixed results [168][169][170]172,[174][175][176][177][178][180][181][182][183][184][185]. Recently, infliximab has been utilized in several patients with refractory IBDassociated orbital inflammation and led to good long-term control [173,179].…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%