Orbital pseudotumor

Dar, IshratH; Dar, ShowkatH; Wazir, HardeepSingh; Qureishi, Tariq; Kamili, MuqtasidA; Ali, Gazanfar

doi:10.4103/0974-620x.53043

Cited by 10 publications

(4 citation statements)

References 10 publications

(29 reference statements)

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“…Orbital pseudotumor was first highlighted by Birch Hirschfield in 1905. Although in most cases it is idiopathic, reports suggest that unknown microbes, minor injuries, and long‐term irritation are the major risk factors for the progression of the condition 7 . Orbital pseudotumor is the third most common orbital disease after thyroid orbitopathy and lymphoproliferative disorder, and it encompasses approximately 10% of all orbital mass lesions 8 .…”

Section: Discussionmentioning

confidence: 99%

Orbital pseudotumor in pediatrics: A single tertiary center experience

Almuqbil

2023

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Orbital pseudotumor in pediatrics: A single tertiary center experience

Almuqbil

2023

Clinical Case Reports

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“…The Romanian case, the endometrial moderate endometrioid carcinoma with squamous component was associated to an ovarian mature teratoma (dermoid cyst), as the Irish published case [6]. Different to these statistical studies of primary origin of an internal tumor signaled by SMJN, there are 15-29% cases [9] with unknown origin of SMJN. One reports at Duke University (USA) during 1988 to 2011, a percentage of 59% from 77 cases of SMJN without the discovery of the primary tumor [22].…”

Section: Sister Mary Joseph Nodule Revisited Many Unanswered Question...mentioning

confidence: 96%

“…The literature presents umbilical skin metastastic tumor nominated "Sister Mary Joseph Nodule" (SMJN) after the name of the catholic sister Mary Joseph Dempsey, who first observed it at Saint Mary's Hospital -actually Mayo Clinic, in Rochester, Minnesota (USA). The umbilical nodules have wide range of presentation from small (<2 cm) to large as 10 cm, sometimes painful, ulcerated mass with sero-sanguineous to bloody discharge [8], coloring the lingerie, or one may discover a diffuse subcutaneous induration, which can be associated to peritoneal carcinomatosis, which worsens the outcome [9]. The Romanian case highlights the assessment challenges when one registers an umbilical nodule, an external manifestation, that must be considered sentinel for an underlying malignancy or other serious disease.…”

Section: Introductionmentioning

confidence: 99%

Sister Mary Joseph Nodule, Umbilical Sentinel for an Endometrioid Endometrial Carcinoma in Postmenopause-Challenges for a Multidisciplinary Approach

2023

JCRC

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A 82 years old, hypertensive, obese, 1 delivery, menopause at 47 yrs, non-smoker, with history of vaginal bleeding in January 2018, is sent by the dermatologist for an irregular umbilical tumor of 2/1 cm, recurrent at 6 weeks post-ablation, microscopically considered as a carcinomatous metastasis. Abdomino-pelvic MRI rises the suspicion of uterine carcinoma, which is confirmed by endometrial biopsy. It is done extrafascial total hysterectomy with bilateral salpingo-oophorectomy, and pelvic lymph dissection and ablation, plus ablation of a skin-adipose-conjunctive peri-and subumbilical area of 5/4 cm. There were no peritoneal metastases, or other viscera abnormalities. The optic microscopy shows moderate differentiated endometrioid endometrial carcinoma, with areas of squamous differentiation, invasion in external myometrial half, without peritoneal invasion, with vessels metastatic embolism, positive pelvic lymph nodes with moderate differentiated endometrioid endometrial carcinoma and desmoplastic reaction; left ovary with mature teratoma. Umbilical specimen has malignant invasion with cribriform and tubular pattern, areas of squamous differentiation, and malignant emboli in vessels. The patient suffered radiotherapy, under oncologic monitoring. The follow up at 6,12,18 and 36 months was with no recurrence in genital, pelvis, peritoneum, abdominal wall. Sister Mary Joseph Nodule (SMJN) has an old history: first observations of assistant catholic nun Mary Joseph Dempsey (Saint Mary’s Hospital, Rochester, Minnesota, USA), William Mayo (1928) description, Hamilton Bailley (1949) characterization. Literature associates SMJN to cancers originating in gastro-intestinal, colonic tract, respiratory, urinary and genital tract: primary ovarian and endometrial cancers; Romanian case is the 36th with endometrial origin. Umbilical invasion may be due to direct vessels’ embolization by malignant endometrial cells, via lymphatics which run along the obliterated umbilical vein, or via the remnant structures of the falciform and umbilical ligaments. Patient is under oncologic monitoring on hormone therapy (Megesin®), with good prognosis up to four years of follow up, different from literature mentioned bad prognosis.

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“…IOID accounts for 4.1−6.3% of orbital disorders and most commonly occurs in the adult population. 2 IOID is diagnosed by clinical history and evaluation to rule out other causes of orbital disease. Some cases of IOID may mimic some of the common conditions such as orbital cellulitis and thyroid eye disease, so it should be considered as a diagnosis of exclusion, with an evaluation that is directed towards eliminating the other causes of orbital disease.…”

Section: Introductionmentioning

confidence: 99%

Orbital pseudotumor masquerading orbital cellulitis

Djeamourthy¹,

Prasanth

Priya³

et al. 2021

IJOOO

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Here with presenting a case of pseudotumor orbit initially diagnosed as orbital cellulitis which responded to steroids. A 44 year old male presented with complaints of swelling, redness, watering and inability to open the right eye for 1 day. He had no h/o trauma or insect bite. On examination, visual acuity in both eyes was 6/6. The right eye was proptosed with gross restriction of the extra ocular movements, conjunctival congestion and chemosis. The intra ocular pressure was 52 mm Hg. The left eye was normal. CT orbit showed enlargement of right lateral rectus muscle and lacrimal gland, with fat stranding and soft tissue thickening of periorbital, pre septal and perinasal regions diagnostic of pseudotumor tumour. He was started on high dose oral steroids with which he improved dramatically.

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Orbital pseudotumor

Cited by 10 publications

References 10 publications

Orbital pseudotumor in pediatrics: A single tertiary center experience

Orbital pseudotumor in pediatrics: A single tertiary center experience

Sister Mary Joseph Nodule, Umbilical Sentinel for an Endometrioid Endometrial Carcinoma in Postmenopause-Challenges for a Multidisciplinary Approach

Orbital pseudotumor masquerading orbital cellulitis

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