Orbital paraganglioma: report of a rare case

Sharma, Mehar Chand; Epari, Sridhar; Gaikwad, Shailesh; Verma, Abhay Kumar; Sarkar, Chitra

doi:10.1016/s0008-4182(05)80061-4

Cited by 16 publications

(13 citation statements)

References 8 publications

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“…In humans, the best long-term tumour control has been achieved by a combination of surgery and radiation therapy after early diagnosis (Gujrati and Donald, 2005). Even if salt-and-pepper MR appearance of this equine tumour resembles that described in human counterparts, conventional imaging does not offer key clues to deciphering the cellular origin (Sharma et al, 2005). One step forward in the diagnosis of neuroendocrine neoplasms was made by Bustillo et al (2004) who performed octreotide scintigraphy in the human head and neck tumours.…”

Section: Discussionmentioning

confidence: 99%

Imaging Features and Decision Making in Retrobulbar Neuroendocrine Tumours in Horses – Case Report and Review of Literature

Matiasek¹,

Cronau

Schmahl³

et al. 2007

Journal of Veterinary Medicine Series A

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SummaryA 25-year-old Haflinger gelding was evaluated for chronicprogressive unilateral exophthalmos. Ultrasonographic investigation and magnetic resonance (MR) imaging revealed a retrobulbar space-occupying mass to be the cause of eyeball displacement. Ultrasonographic features were not sufficient to specify the type and extension of the lesion. Magnetic resonance scans, however, clearly displayed an infiltrative intracranial growth pattern but sparing of orbital soft tissues. Based on MR appearance, tentative diagnosis of an orbital soft tissue neoplasia was made and subsequently confirmed by histopathological investigation. The latter revealed a poorly differentiated neuroendocrine tumour. Retrospectively, MR changes resembled those seen with neuroendocrine neoplasms of the human skull. Even if histopathology remains to be elucidated by cytological or histological inspection, MR imaging of equine orbital tumours should provide the criteria necessary for evaluating the therapeutic options and associated prognosis.

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Section: Discussionmentioning

confidence: 99%

Imaging Features and Decision Making in Retrobulbar Neuroendocrine Tumours in Horses – Case Report and Review of Literature

Matiasek¹,

Cronau

Schmahl³

et al. 2007

Journal of Veterinary Medicine Series A

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“…12 Incomplete excision with close surveillance is an option for patients with orbital paragangliomas abutting the optic nerve (►Table 4). 17 Of the eight patients in our study who had paragangliomas attached to the optic nerve, four (50%) developed recurrences. Exenteration should be offered to patients with rapidly expanding tumors, tumors resulting in a significant decrease in vision, tumors that are locally invasive resulting in cranial nerve neuropathies and for recurrent tumors.…”

Section: Treatmentmentioning

confidence: 68%

Orbital Paraganglioma: A Systematic Review

et al. 2017

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The purpose of this study was to perform a systematic review of the literature on orbital paragangliomas, evaluating clinical presentation, diagnosis, management patterns, and prognosis. The systematic review was conducted based on the principles described in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. PubMed, Cochrane databases, Embase, and Web of Science were searched for articles related to orbital paragangliomas. Inclusion criteria included English language articles with original reports on human subjects. Data on clinical presentation, diagnosis, treatment, and prognosis were collected. Twenty-seven articles met inclusion criteria (28 total patients). The mean patient age was 37.1 years (range, 3-75 years); 13 (46.4%) patients were male. The most common presenting symptoms were proptosis (89.2%), visual acuity changes (67.9%), and extraocular muscle restriction (64.2%). Lesions were most commonly intraconal (92.9%). Single modality therapy was employed in 19 patients (67.9%), including excision in 12 patients (42.9%) and exenteration in 5 patients (17.9%). Ten patients (35.7%) developed recurrence, and there was a 92.9% survival rate (mean follow-up, 29 months). Orbital paragangliomas are rare tumors with an excellent prognosis. These lesions commonly present with proptosis, and are primarily managed surgically with simple excision, although exenteration and adjuvant radiation may be necessary for invasive tumors. This series is the largest and most comprehensive systematic review of orbital paragangliomas conducted to date.

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“…Paragangliomas are rarely seen in the head and neck region (less than 3%), and very rarely, this tumour may be seen within the orbit, with fewer than 40 cases reported in the literature [1,5]. Paragangliomas show a definite familial incidence, with up to 35% of these tumours being hereditary [4].…”

Section: Discussionmentioning

confidence: 99%

“…They sense fluctuations in blood pH and oxygen tension and help in their homeostasis [1,2]. Paragangliomas are neuroendocrine tumours that arise from the paraganglia and are found frequently neighbouring vascular structures.…”

Section: Introductionmentioning

confidence: 99%

Orbital Paraganglioma and Succinate Dehydrogenase Staining for Genetic Testing Triage and Prognosis

Rosa

2015

Ocul Oncol Pathol

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Purpose of the Study: To describe the rare occurrence of a paraganglioma in the orbit and how to triage for genetic testing and assess the prognosis with succinate dehydrogenase subunit B (SDHB) immunohistochemical staining. Method: Case report. Procedures: A 47-year-old ‘healthy' male presented with painless exophthalmos and diplopia secondary to an infraorbital tumour mass. Results: The orbital biopsy was diagnosed as paraganglioma with positive staining with SDHB. Conclusion: The rarity of an orbital paraganglioma was followed by the clinical search for a possible occult extraorbital primary paraganglioma. SDHB staining helped in the triage for genetic testing and gave an idea about the prognosis for this tumour.

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Orbital paraganglioma: report of a rare case

Cited by 16 publications

References 8 publications

Imaging Features and Decision Making in Retrobulbar Neuroendocrine Tumours in Horses – Case Report and Review of Literature

Imaging Features and Decision Making in Retrobulbar Neuroendocrine Tumours in Horses – Case Report and Review of Literature

Orbital Paraganglioma: A Systematic Review

Orbital Paraganglioma and Succinate Dehydrogenase Staining for Genetic Testing Triage and Prognosis

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