Orbital paecilomycosis due to<i>Paecilomyces lilacinus</i>(Thom) Samson

Agrawal, Pawan K.; B, Lal; Wahab, Seema; Srivastava, O. P.; Misra, Sanjeev

doi:10.1080/00362177985380541

Cited by 37 publications

(11 citation statements)

References 10 publications

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“…Results of animal inoculation experiments [1] reinforce the concept of P. lilacinus as an opportunistic invader. Intracorneal inoculation produced corneal opacity, congestion, edema of the lids, and ulcers in eyes pretreated with corticosteroid but not in eyes not so conditioned.…”

Section: Discussionsupporting

confidence: 54%

“…treated successfully with pimaricin, and one of orbital granuloma [1] which failed to respond to intravenous amphotericin B. P. lilacinus has also been implicated in a case of chronic maxillary sinusitis [14]; in a cutaneous condition in a 20-year-old woman, in which erythematous scaly plaques persisted for 15 years [17]; and in a case of pleural effusion in a 20-year-old man, which responded to amphotericin B [2]. A potential for more serious involvement is indicated by a recent report of systemic infection in an armadillo [4].…”

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confidence: 96%

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Corneal transplant infection byPaecilomyces lilacinus

Gordon

Norton

1985

Med Mycol

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Paecilomyces lilacinus was cultured from an ulcerated corneal transplant, sections of which, following surgical removal, revealed dense mycelial growth throughout the corneal remnant and penetrating Descemet's membrane. PAS-stained sections showed, in addition to the hyphae, numerous small, ovoid elements consistent with conidia of P. lilacinus. Infection apparently had spread to the transplant from the recipient's cornea. The fungal isolate proved resistant, in vitro, to amphotericin B, 5-fluorocytosine, and pimaricin, but sensitive to ketoconazole and moderately sensitive to miconazole. Following a second transplant and intensive antifungal therapy, the infection appears to have been eliminated.Paecilomyces lilacinus (Thorn) Samson 1974 is a common soil-dwelling mold which seldom has been associated with human disease. However, it is often found in tap water and is a notorious contaminant of sterile solutions, which largely accounts for the fact that the majority of infections by this species have occurred in connection with surgical procedures involving the eyes. The first reported case of endophthalmitis attributed to P. lilacinus resulted from an iridencleisis performed to alleviate glaucoma[10]. The eye was saved with the aid of amphotericin B injected subconjunctivally and into the anterior chamber, but vision was reduced to bare light perception. As second case followed cataract extraction [8]. The most extensive series of P. lilacinus infections in the United States occurred in 1975 [13], with 12 cases of endophthalmitis, all of them following cataract extraction, scattered throughout the country. In 11 of these a Luminex lens, and in the twelth a Rayner lens, had been implanted. P. lilacinus was isolated from the bicarbonate neutralizing solution of an unused Luminex lens package in association with some of the cases. In this series, according to O'Day [13], six eyes were lost and vision was seriously impaired in the remainder, therapy with amphotericin B and 5-fluorocytosine having proven ineffective. Subsequently, Miller et al. [12] reported that one of these eyes was salvaged and the fungal infection eliminated after surgery and treatment with several antifungal agents. Additional cases with ocular involvement comprised two of keratitis [3,6], one of which was

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Section: Discussionsupporting

confidence: 54%

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confidence: 96%

Corneal transplant infection byPaecilomyces lilacinus

Gordon

Norton

1985

Med Mycol

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“…Another species, P. lilacinus, was reported as the cause of maxillary sinusitis in two cases (11,13). Paecilomyces lilacinus was also found to be the agent ofan interesting case of orbital paecilomycosis (1). The fungus was presumed to have found access to the orbit by the nasal/ paranasal route.…”

Section: Discussionmentioning

confidence: 99%

Paecilomycosis of the Maxillary Sinus

Otčenášek

Jirousek

Nozĭcka

et al. 1984

Mycoses

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Summary: The case is presented of a 23‐year‐old female with maxillary sinusitis causing pain in the left cheek and headache. In a biopsy specimen taken from the maxillary sinus the fungus Paecilomyces variotii Bainier was demonstrated histologically and mycologically. The Caldwell‐Luc operation with exteriorization and aeration of the involved sinus led to cure. The present data on the role in human pathology of fungi of the genus Paecilomyces are summarized. Zusammenfassung: Es wird der Fall einer dreiundzwanzigjährigen Frau mit einer Kieferhöhlenentzündung beschrieben, die Schmerzen in der linken Gesichtshälfte und im Kopf verursachte. In dem bioptischen Material, das aus der Kieferhöhle gewonnen wurde, wies man histologisch und mykologisch den Pilz Paecilomyces variotii Bainier nach. Die Caldwell‐Luc‐Operation mit einer Exteriorisation und Durchlüftung der befallenen Kieferhöhle brachte die Heilung der Patientin. Die Autoren faßten die bisherigen Angaben über die Bestätigung des Pilzes aus der Gattung Paecilomycoses in der Humanpathologie zusammen.

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“…It has occasionally been reported as a zoo pathogen causing particularly pulmonary and cutaneous infections (Fenech & Mallia, 1972;Takayasu et al, 1977;Chandler et a!., 1980). It has also played a role in keratitis (Halde & Okumoto, 1966;Forster & Rebell, 1975) and orbital granuloma (Agrawal et al, 1979). More recently Gordon & Norton (1985) have isolated this fungus from an ulcerated corneal transplant.…”

Section: Discussionmentioning

confidence: 99%

Pathogenic Fungi in Soils of Jabalpur, India

Pandey

Agrawal

Singh

1990

Mycoses

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Results of a preliminary survey of pathogenic fungi in soils collected from forest, riverside and residential garbage soil in Jabalpur, India, are reported. A total of 45 soils samples were examined, of which 39 (87%) were positive for fungi, 66 species of fungi classified in 35 genera were isolated: Chrysosporium (78%), Fusarium (69%), Aspergillus (47%), Microsporum (38%), Gliocladium (16%), Acremonium (11%), Penicillium (11%), Humicola (9%), Scopulariopsis (7%), Paecilomyces (7%), Cladosporium (7%); Chaetomium, Colletotrichum, Cunninghamella, Microascus and Rhizopus (4% each); Absidia, Aphanocladium, Arthrobotrys, Botryotrichum, Candida, Cephaliophora, Cephalosporium, Curvularia, Histoplasma, Mucor, Shanorella, Syncephalastrum, Thermomyces, Trichophyton, Trichothecium and Verticillium (2% each); mycelia sterilia (6%). Acremonium persicinum, Cladosporium trichoides and Shanorella spirotricha are new to India. A new species of Humicola has also been isolated.

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Orbital paecilomycosis due toPaecilomyces lilacinus(Thom) Samson

Cited by 37 publications

References 10 publications

Corneal transplant infection byPaecilomyces lilacinus

Corneal transplant infection byPaecilomyces lilacinus

Paecilomycosis of the Maxillary Sinus

Pathogenic Fungi in Soils of Jabalpur, India

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