Orbital metastasis as the presenting symptom of extensive stage small cell lung cancer

Henning, Michelle; Hu, Qiyue; Siegelmann‐Danieli, Nava

doi:10.1016/j.ejim.2007.03.011

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…The most frequently involved sites of origin include breast, lung, and prostate carcinoma [ 1 ]. Curiously, hepatocellular and gastric cancer orbital metastases correspond to the most frequent etiology in Japanese patients [ 3 , 4 ]. Extraocular muscle metastases represent 9% of orbital metastasis.…”

Section: Discussionmentioning

confidence: 99%

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Metastasis of small cell lung cancer to bilateral extraocular muscles: a case report

Ramalhão,

Vieira,

Rodrigues

et al. 2024

J Med Case Reports

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Background Orbital metastasis is a possible complication of small cell lung cancer and a pattern of bilateral invasion of the extraocular muscles has rarely been reported in literature. Case presentation A 46-year-old white male with a past medical history of smoking and stage IV small cell lung carcinoma presented with loss of vision and pain in the left eye. Examination revealed bilateral proptosis and left afferent pupillary defect, and visual acuity was hand motion on the left eye and 4/10 on the right eye. An orbital computed tomography scan showed a compression of the left optic nerve between the extraocular muscles at the apex, and a lateral canthotomy was performed for a new-onset compressive optic neuropathy, with residual visual improvement. There was also significant enlargement of the extraocular muscles in the right orbit. The patient was maintained in palliative treatment with both chemotherapy and local medical and surgical (amniotic membrane cover for exposure keratopathy) ophthalmological treatments until he eventually died 5 months after. Conclusion Bilateral metastasis to the extraocular muscles is a very rare manifestation of small cell lung cancer and the palliative treatment in these cases is challenging.

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Section: Discussionmentioning

confidence: 99%

“…Few cases of orbital metastases from SCLC have been described in literature [ 3 , 13 , 14 ]. Tezcan et al .…”

Section: Discussionmentioning

confidence: 99%

Metastasis of small cell lung cancer to bilateral extraocular muscles: a case report

Ramalhão,

Vieira,

Rodrigues

et al. 2024

J Med Case Reports

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“…The most common symptoms of any kind of orbital tumor upon presentation are proptosis, periorbital pain, orbital swelling, and diplopia, as well as restriction of extraocular movements [ 10 ]. Orbital ESCCs tend to present very similarly to more common and non-neoplastic orbital pathology such as orbital abscess [ 9 ] or episcleritis as seen in the present case.…”

Section: Discussionmentioning

confidence: 99%

Extrapulmonary Small Cell Carcinoma Presenting as an Orbital Mass: A Case Report

Meinhardt¹,

Uppuluri²,

Shkolnik³

et al. 2022

Cureus

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Extrapulmonary small cell carcinomas (ESCCs) are poorly differentiated neuroendocrine tumors that are characterized by an aggressive course and poor survival rates. While these tumors can be found anywhere in the body, presentations of lesions in the orbit are exceedingly rare. We present the case of a 47-year-old man who presented with blurry vision, lacrimation, and tenderness of his right eye, as well as a small but palpable temporal mass. Upon workup, he was diagnosed with ESCC in the orbit as well as lesions in the liver and spine. He received systemic chemotherapy but unfortunately proceeded to have rapid spread of his disease and succumbed to this cancer only a year after presentation. This patient illustrates the importance of developing optimal treatment strategies, which have yet to be delineated, and especially the impact of newer immunotherapy agents remains to be seen.

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“…Small cell lung cancer (SCLC) is a well-known malignancy, having an early spread and multi-organ involvement; however, there are only a few reported cases of orbital metastases present as diffuse and large tumor destroying the bony orbit (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Solitary Orbital Metastasis Presenting as Extraocular Muscle Mass in Lung Cancer Patient: A Case Report

Kim

et al. 2017

J Korean Soc Radiol

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Orbital metastasis as the presenting symptom of extensive stage small cell lung cancer

Cited by 7 publications

References 5 publications

Metastasis of small cell lung cancer to bilateral extraocular muscles: a case report

Metastasis of small cell lung cancer to bilateral extraocular muscles: a case report

Extrapulmonary Small Cell Carcinoma Presenting as an Orbital Mass: A Case Report

Solitary Orbital Metastasis Presenting as Extraocular Muscle Mass in Lung Cancer Patient: A Case Report

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