Orbital melanotic neuroectodermal tumor of infancy successfully treated with chemotherapy and subtotal excision

Hered, Robert W.; Smithwick, Walter; Sandler, Eric; Goldstein, Jeffrey

doi:10.1016/j.jaapos.2007.03.010

Cited by 13 publications

(9 citation statements)

References 8 publications

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“…1,5 Chemotherapy and radiotherapy have been used as adjuncts in such cases, with varying reports of success in reducing morbidity and mortality. [6][7][8] The management of a metatstatic mandibular tumor, in particular, has only been documented in one other case. 9 The purpose of this case report is to present treatment and reconstruction considerations in a metastatic mandibular MNTI and to review the associated literature.…”

Section: Introductionmentioning

confidence: 99%

Metastatic Melanotic Neuroectodermal Tumor of Infancy: Report of a Case and Review of the Literature

Azarisamani

Petrisor

Wright

et al. 2016

Journal of Oral and Maxillofacial Surgery

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Section: Introductionmentioning

confidence: 99%

Metastatic Melanotic Neuroectodermal Tumor of Infancy: Report of a Case and Review of the Literature

Azarisamani

Petrisor

Wright

et al. 2016

Journal of Oral and Maxillofacial Surgery

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“…Chemotherapy has been used in association with surgery, particularly when the tumor can not be totally resected, if there is history of recurrences, if the tumor has a malignant aspect on histology or if there are metastasis. Several chemotherapeutic protocols have been suggested, but there are no gold standards (13,14,16). It is observed that chemotherapy has a partial effect, with good results in neuroblastic areas of the tumor and poor results in epithelial areas (15).…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of choice is surgical resection. However, in very particular situation, such as in inoperable cases, other modalities of treatment including chemotherapy has been used (13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Melanotic Neuroectodermal Tumor of Infancy: a Clinicopathological Case Report

et al. 2018

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Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that affects mainly children under 1 year of age. A 4-month-old boy was referred for evaluation of a lesion with 1 month of evolution. Intra-oral examination detected a firm upon palpation submucosal nodular mass, measuring 1.5 cm in diameter, affecting the anterior maxillary alveolar ridge and covered by a slightly blue mucosa with evident telangiectasia. The patient underwent an incisional biopsy and histological and immunohistochemical analyses revealed nests of AE1/AE3 positive epithelioid cells with abundant melanin pigmentation. Other cell types, resembling neuroblasts, were also present and positive for CD56, synaptophysin and enolase. The diagnosis of MNTI was established and the patient was referred for treatment. Conservative surgical resection was performed along with 3 adjacent teeth under general anesthesia. The patient is in follow-up for 1,5 year without recurrence. Conservative surgical management of MNTI may be an alternative to maxillectomy, contributing to the patient´s quality of life.

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“…Various chemotherapeutic regimens have been reported for management of MNTI 7-13 ; however, to date, no single protocol has been identified as the gold standard of chemotherapy. Initially, our patient was started on vincristine and cyclophosphamide because of the known effectiveness of these agents in neuroblastoma-type tumors.…”

Section: Discussionmentioning

confidence: 99%